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Urothelial Carcinoma

Methods and Protocols

  • Book
  • © 2023
  • Latest edition

Overview

Editors:
  1. Michèle J. Hoffmann

    1. Department of Urology, Medical Faculty and University Hospital, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

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  2. Nadine T. Gaisa

    1. Institute of Pathology, University Hospital, RWTH Aachen University, Aachen, Germany

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  3. Roman Nawroth

    1. Department of Urology, University Hospital Rechts der Isar, Technical University Munich, Munich, Germany

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  4. Thorsten H. Ecke

    1. Department of Urology, Helios Hospital, Bad Saarow, Germany

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  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2684)

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Table of contents (20 protocols)

  1. Front Matter

    Pages i-xi
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  2. Molecular Characterization

    1. Front Matter

      Pages 1-1
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    2. Scoring Systems for Immunohistochemistry in Urothelial Carcinoma

      • Mark-Sebastian Bösherz, Iryna V. Samarska, Nadine T. Gaisa
      Pages 3-25

    3. A Panel-Based Method for the Reproduction of Distinct Molecular Subtype Classifications of Muscle-Invasive Urothelial Bladder Cancer

      • Csilla Olah, Tibor Szarvas
      Pages 27-43

    4. Analysis of Mutational Signatures Using the mutSignatures R Library

      • Damiano Fantini, Joshua J. Meeks
      Pages 45-57

    5. A Drug Repurposing Pipeline Based on Bladder Cancer Integrated Proteotranscriptomics Signatures

      • Marika Mokou, Shaman Narayanasamy, Rafael Stroggilos, Irina-Afrodita Balaur, Antonia Vlahou, Harald Mischak et al.
      Pages 59-99

    6. Characterization of Native COMPASS Complex in Urothelial Carcinoma Cells by Size Exclusion Chromatography

      • Christoph Peter, Wolfgang A. Schulz, Patcharawalai Whongsiri
      Pages 101-109

  3. Urothelial Carcinogenesis

    1. Front Matter

      Pages 111-111
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    2. Reconstructing Phylogenetic Relationship in Bladder Cancer: A Methodological Overview

      • Lancelot Seillier, Martin Peifer
      Pages 113-132

    3. Using Sister Chromatid Exchange Assay to Detect Homologous Recombination Deficiency in Epigenetically Deregulated Urothelial Carcinoma Cells

      • Theodoros Rampias, Apostolos Klinakis
      Pages 133-144

    4. Identification of STAG2-Mutant Bladder Cancers by Immunohistochemistry

      • Youngrok Park, Alana Lelo, Brent Harris, Deborah L. Berry, Krysta Chaldekas, Jung-Sik Kim et al.
      Pages 145-151

  4. Cellular and Animal Models

    1. Front Matter

      Pages 153-153
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    2. Genome-Wide CRISPR Screening for the Identification of Therapy Resistance-Associated Genes in Urothelial Carcinoma

      • Klaus Mantwill, Roman Nawroth
      Pages 155-165

    3. Tissue Slice Culture and Analysis of Tumor-Associated Hyaluronan in Urothelial Carcinoma

      • William Donelan, Paul L. Crispen, Sergei Kusmartsev
      Pages 167-175

  5. Biomarkers

    1. Front Matter

      Pages 177-177
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    2. NGS-Based Tumor-Informed Analysis of Circulating Tumor DNA

      • Iver Nordentoft, Karin Birkenkamp-Demtröder, Lars Dyrskjøt
      Pages 179-197

    3. Considering the Effects of Modern Point-of-Care Urine Biomarker Assays in Follow-Up of Patients with High-Risk Non-muscle-Invasive Bladder Cancer

      • Thorsten H. Ecke, Natalya Benderska-Söder, Ekkehardt Bismarck, Bas W. G. van Rhijn, Tilman Todenhöfer, Bernd J. Schmitz-Dräger
      Pages 199-212

    4. Simplex Droplet Digital PCR Assays for the Detection of TERT Promoter Mutations in Urine Samples for the Non-invasive Diagnosis of Urothelial Cancer

      • Maria Zvereva, Md Ismail Hosen, Nathalie Forey, Mahdi Sheikh, Caroline Kannengiesser, Ibrahima Ba et al.
      Pages 213-228

    5. Predictive Biomarkers of Response to Neoadjuvant Therapy in Muscle Invasive Bladder Cancer

      • Jussi Nikkola, Peter Black
      Pages 229-247

    6. Assessment of PD-L1 Status in Urothelial Cancer

      • Veronika Bahlinger, Arndt Hartmann, Markus Eckstein
      Pages 249-255
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Keywords

About this book

This fully updated volume explores recently improved avenues to study urothelial carcinomas. Beginning with several novel chapters on molecular characterization and urothelial carcinogenesis, the book continues with sections on cellular and animal models, biomarkers, and approaches for targeted therapy. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Urothelial Carcinoma: Methods and Protocols, Second Edition serves as a valuable resource to further increase our knowledge on urothelial carcinoma and also to aid research on numerous other cancers.

Editors and Affiliations

  • Department of Urology, Medical Faculty and University Hospital, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

    Michèle J. Hoffmann

  • Institute of Pathology, University Hospital, RWTH Aachen University, Aachen, Germany

    Nadine T. Gaisa

  • Department of Urology, University Hospital Rechts der Isar, Technical University Munich, Munich, Germany

    Roman Nawroth

  • Department of Urology, Helios Hospital, Bad Saarow, Germany

    Thorsten H. Ecke

Bibliographic Information

  • Book Title: Urothelial Carcinoma

  • Book Subtitle: Methods and Protocols

  • Editors: Michèle J. Hoffmann, Nadine T. Gaisa, Roman Nawroth, Thorsten H. Ecke

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-3291-8

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2023

  • Hardcover ISBN: 978-1-0716-3290-1Published: 07 July 2023

  • Softcover ISBN: 978-1-0716-3293-2Due: 07 August 2023

  • eBook ISBN: 978-1-0716-3291-8Published: 06 July 2023

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XI, 331

  • Number of Illustrations: 4 b/w illustrations, 51 illustrations in colour

  • Topics: Cancer Research, Cancer Research

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