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Determination of the Microstructure of Decellularized Dermal Scaffolds

  • POLYMER, BIOORGANIC, AND HYBRID NANOMATERIALS
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Abstract—

One of the most important aspects of regenerative medicine is the selection of the scaffold—the biological skeleton of the tissue-engineering structure. To reproduce the structure and properties of damaged tissue and maintain the cell adhesion and proliferation, it is optimal to use scafflds obtained by decellularization of native organs with subsequent recellularization of various cell lines. Using the methods of environmental scanning electron microscopy and scanning pulsed ultrasound microscopy, the microstructure of native and decellularized matrixes of dermal tissues was determined.

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Funding

The study work was supported by the Russian Science Foundation (grant no. 17-13-01376) on the topic “Visualization of Adhesion and Proliferation of Stromal and Epithelial Cells on Various Types of Matrices based on Biocompatible Polymers.”

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Authors and Affiliations

  1. National Research Center Kurchatov Institute, Moscow, Russia

    R. A. Kamyshinsky, K. G. Antipova, T. D. Patsaev, T. E. Grigoryev & A. L. Vasiliev

  2. Federal Scientific Research Center Crystallography and Photonics, Russian Academy of Sciences, Moscow, Russia

    R. A. Kamyshinsky & A. L. Vasiliev

  3. Scientific Research Institute of Medical Primatology, Sochi, Russia

    E. V. Kuevda & E. A. Gubareva

  4. Kuban State Medical University, Krasnodar, Russia

    D. M. Kuznetsova

  5. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

    E. S. Morokov & E. A. Khramtsova

  6. Volga Research Medical University, Russian Health Ministry, Nizhny Novgorod, Russia

    D. Ya. Aleinik & M. N. Egorikhina

Authors
  1. R. A. Kamyshinsky
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  2. K. G. Antipova
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  3. E. V. Kuevda
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  4. D. M. Kuznetsova
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  5. T. D. Patsaev
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  6. E. S. Morokov
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  7. E. A. Khramtsova
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  8. D. Ya. Aleinik
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  9. M. N. Egorikhina
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  10. T. E. Grigoryev
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  11. E. A. Gubareva
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  12. A. L. Vasiliev
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Corresponding author

Correspondence to A. L. Vasiliev.

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Kamyshinsky, R.A., Antipova, K.G., Kuevda, E.V. et al. Determination of the Microstructure of Decellularized Dermal Scaffolds. Nanotechnol Russia 14, 362–366 (2019). https://doi.org/10.1134/S1995078019040074

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  • DOI: https://doi.org/10.1134/S1995078019040074

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