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Decellularization of Skin Tissue

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Decellularization Methods of Tissue and Whole Organ in Tissue Engineering

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1345))

Abstract

Biomaterials science encompasses elements of medicine, biology, chemistry, materials, and tissue engineering. They are engineered to interact with biological systems to treat, augment, repair, or replace lost tissue function. The choice of biomaterial depends on the procedure being performed, the severity of the patient’s condition, and the surgeon’s preference. Prostheses made from natural-derived biomaterials are often derived from decellularized extracellular matrix (ECM) of animal (xenograft) or human (allograft) origin. Advantages of using ECM include their resemblance in morphology and three-dimensional structures with that of tissue to be replaced. Due to this, scientists all over are now focusing on naturally derived biomaterials which have been shown to possess several advantages compared to synthetic ones, owing to their biocompatibility, biodegradability, and remodeling properties. Advantages of a naturally derived biomaterial enhance their application for replacement or restoration of damaged organs/tissues. They adequately support cell adhesion, migration, proliferation, and differentiation. Naturally derived biomaterials can induce extracellular matrix formation and tissue repair when implanted into a defect by enhancing attachment and migration of cells from surrounding environment. In the current chapter, we will focus on the natural and synthetic dermal matrix development and all of the progress in this field.

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Authors and Affiliations

  1. Division of Surgery, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, India

    Naveen Kumar, Vineet Kumar, Sanjay Purohit, Anil Kumar Gangwar, Sameer Shrivastava, Swapan Kumar Maiti, Sonal Saxena, Dayamon David Mathews, Pawan Diwan Singh Raghuvanshi, Ajit Kumar Singh & Karam Pal Singh

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  1. Naveen Kumar
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  2. Vineet Kumar
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  3. Sanjay Purohit
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  4. Anil Kumar Gangwar
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  5. Sameer Shrivastava
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  6. Swapan Kumar Maiti
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  7. Sonal Saxena
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  8. Dayamon David Mathews
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  9. Pawan Diwan Singh Raghuvanshi
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  10. Ajit Kumar Singh
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  11. Karam Pal Singh
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Editors and Affiliations

  1. Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Abdol-Mohammad Kajbafzadeh

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Kumar, N. et al. (2021). Decellularization of Skin Tissue. In: Kajbafzadeh, AM. (eds) Decellularization Methods of Tissue and Whole Organ in Tissue Engineering. Advances in Experimental Medicine and Biology, vol 1345. Springer, Cham. https://doi.org/10.1007/978-3-030-82735-9_15

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