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Vitamin D status and response to growth hormone treatment in prepubertal children with growth hormone deficiency

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Abstract

Purpose

To analyze whether vitamin D deficiency could condition the growth response to GH therapy, as well as to analyze if GH treatment modifies both seasonal variations and vitamin D levels in these patients.

Methods

Retrospective study in 98 prepubertal children with GH deficiency (GHD), aged 4.1–8.9 years treated with GH. Growth rate and blood testing (calcium, phosphorus, IGF-I, 25(0H)D and PTH) were monitored at diagnostic and every six months until 24 months of treatment. A control group was recruited (247 healthy children, aged 3.8–9.7 years). The criteria of the US Endocrine Society were used for the definition of hypovitaminosis D.

Results

There were no significant differences in vitamin D deficiency among control (12.5%) and GHD groups (15.3%) before starting treatment. Growth rate and IGF-1 and PTH increased (p < 0.05) during GH treatment, but there were no significant differences in calcium, phosphorus and 25(OH)D. There were no significant differences in growth rate and IGF-1, calcium and phosphorus levels in relation to the seasons along GH treatment. There was no correlation between 25(OH)D and IGF-1 during GH therapy. In every programmed control, patients with vitamin D deficiency showed lower growth rate (p < 0.05) compared to patients with vitamin D insufficiency or sufficiency.

Conclusion

GH treatment, at least during the first two years, does not modify the vitamin D levels. Vitamin D deficiency could condition the response to GH therapy so vitamin D monitoring should be considered as part of the routine evaluation of children with GH treatment.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Funding

The authors received no financial support for the research, authorship, and/or publication of this article (none declared).

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Authors and Affiliations

  1. Department of Pediatrics, School of Medicine, University of Navarra, Pamplona, Spain

    T. Durá-Travé

  2. Department of Pediatrics, Navarra Hospital Complex, Avenue Irunlarrea, 4, 31008, Pamplona, Spain

    T. Durá-Travé, F. Gallinas-Victoriano, P. Moreno-González, M. Urretavizcaya-Martinez, S. Berrade-Zubiri & M. J. Chueca-Guindulain

  3. Navarra Institute for Health Research (IdisNA), Pamplona, Spain

    T. Durá-Travé, S. Berrade-Zubiri & M. J. Chueca-Guindulain

Authors
  1. T. Durá-Travé
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  2. F. Gallinas-Victoriano
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  3. P. Moreno-González
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  4. M. Urretavizcaya-Martinez
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  5. S. Berrade-Zubiri
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  6. M. J. Chueca-Guindulain
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Contributions

TDT and FGV participated in study design and data analysis, and wrote the first draft of the manuscript. PMG, MUM, SBZ and MJCG participated in data collection and analysis. All authors participated in manuscript preparation and approved its final version.

Corresponding author

Correspondence to T. Durá-Travé.

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Conflicts of interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article (none declared).

Ethical approval

This study was approved by the Ethics Committee for Human Investigation of the Navarra Hospital Complex, Pamplona, Spain (code: 19/07) in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and later amendments.

Informed consent

Parents and/or legal guardians were appropriately informed and gave consent for the participation of the participants in this study in all cases.

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Durá-Travé, T., Gallinas-Victoriano, F., Moreno-González, P. et al. Vitamin D status and response to growth hormone treatment in prepubertal children with growth hormone deficiency. J Endocrinol Invest 43, 1485–1492 (2020). https://doi.org/10.1007/s40618-020-01227-3

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  • DOI: https://doi.org/10.1007/s40618-020-01227-3

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