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Association Between Vitamin D and Carboxy-Terminal Cross-Linked Telopeptide of Type I Collagen in Children During Growth Hormone Replacement Therapy

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Clinical Investigation

Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 1047))

Abstract

Growth hormone and insulin-like growth factor-1 (IGF-1) play a crucial role in the regulation of bone turnover. Adequate vitamin D status supports proper bone remodeling, leading to normal longitudinal bone growth and normal peak bone mass. The aim of this study was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] and carboxy-terminal cross-linked telopeptide of type I collagen (ICTP) in children and adolescents with growth hormone deficiency at baseline and during recombinant human growth hormone (rhGH) replacement therapy. The study was prospective and included 30 children and adolescents aged 5 to 17 years. Concentrations of 25(OH)D, ICTP, and IGF-1 were measured at baseline and during the first year of rhGH therapy. Baseline serum 25(OH)D concentration correlated with ICTP concentrations during the first trimester of rhGH therapy (r = 0.38, p < 0.050); the correlation was stronger in the second trimester of therapy (r = 0.6, p = 0.002). We conclude that proper vitamin D status is important in reaching the adequate dynamics of bone remodeling during growth, which is essential to achieve a catch-up growth during rhGH therapy.

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Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

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Authors and Affiliations

  1. Department of Paediatrics and Endocrinology, Medical University of Warsaw, 63A Żwirki and Wigury Street, 02-091, Warsaw, Poland

    Ewelina Witkowska-Sędek, Anna Kucharska & Beata Pyrżak

  2. Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland

    Anna Stelmaszczyk-Emmel & Urszula Demkow

Authors
  1. Ewelina Witkowska-Sędek
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  2. Anna Stelmaszczyk-Emmel
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  3. Anna Kucharska
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  4. Urszula Demkow
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  5. Beata Pyrżak
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Corresponding author

Correspondence to Ewelina Witkowska-Sędek .

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Editors and Affiliations

  1. Opole Medical School, Opole, Poland

    Mieczyslaw Pokorski

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Witkowska-Sędek, E., Stelmaszczyk-Emmel, A., Kucharska, A., Demkow, U., Pyrżak, B. (2017). Association Between Vitamin D and Carboxy-Terminal Cross-Linked Telopeptide of Type I Collagen in Children During Growth Hormone Replacement Therapy. In: Pokorski, M. (eds) Clinical Investigation. Advances in Experimental Medicine and Biology(), vol 1047. Springer, Cham. https://doi.org/10.1007/5584_2017_109

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