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Investigation of Silver-Doped Iron Oxide Nanostructures Functionalized with Ionic Liquid for Colorimetric Sensing of Hydrogen Peroxide

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Abstract

Hydrogen peroxide (H2O2) is a by-product of oxidase-catalyzed reactions that serves as a signaling molecule and can cause DNA and protein damage. This leads to an increase in our susceptibility toward various kinds of diseases including diabetes mellitus and hypertension, The novelty of this work lies in the synergistic effect of all three components of the Ag-Fe2O3-IL composite for the colorimetric detection of H2O2. Silver-doped iron oxide nanostructures (Ag-Fe2O3 NS) were synthesized and then coated with ionic liquid (IL) having peculiar characteristics of aromaticity and conductivity to enhance their properties. The prepared Ag-Fe2O3 nanoparticles were characterized through spectroscopic techniques namely FTIR, XRD, SEM and EDX. The characterized Ag-Fe2O3 NS and 3, 3', 5, 5' Tetramethylbenzidine (TMB) solutions were employed for the colorimetric sensing of H2O2. To optimize the proposed sensor different reaction conditions including (a) amount of Ag-Fe2O3NS/IL (b) TMB, (c) pH, (d) H2O2 concentration and (e) incubation time were optimized. At optimum conditions, the desired sensor showed a wide linear range 1 × 10−9–3.2 × 10−7 M, a lower limit of quantification 3.20 × 10−7 M, and a limit of detection 1.07 × 10−8 M with a 0.9996 R2 value. The selectivity of the proposed sensor was compared with the potential interfering species and the incubation time was just 5 min. Additionally, the sensor was effectively applied for detecting hydrogen peroxide in the urine samples of diabetes mellitus patients.

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Acknowledgements

The authors are grateful to the Department of Chemistry, Kohat University of Science and Technology (Grant No. General research support), Kohat, for providing necessary funding and infrastructure for the project. UN is grateful to TWAS and CNPq for providing support to researchers in the developing world.

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Authors and Affiliations

  1. Department of Chemistry, Kohat University of Science and Technology (KUST), Kohat, 26000, KPK, Pakistan

    Umar Nishan, Ikram Ullah, Saifullah Afridi, Muhammad Asad, Shams Ul Haq & Mansoor Khan

  2. Department of Dental Materials, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan

    Nawshad Muhammad

  3. Faculty of Science and Arts, Chemistry Department, Erciyes University, 38039, Kayseri, Turkey

    Mustafa Soylak

  4. Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Lahore, 54000, Pakistan

    Abdur Rahim

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  1. Umar Nishan
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Nishan, U., Ullah, I., Muhammad, N. et al. Investigation of Silver-Doped Iron Oxide Nanostructures Functionalized with Ionic Liquid for Colorimetric Sensing of Hydrogen Peroxide. Arab J Sci Eng 48, 7703–7712 (2023). https://doi.org/10.1007/s13369-023-07791-z

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