Skip to main content

Advertisement

SpringerLink
Log in

The Role of Tumor Necrosis Factor-α (TNF-α) Polymorphisms in Gastric Cancer: a Meta-Analysis

  • Review Article
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

Abstract

Purpose

Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine which may play a role in the development of gastric cancer (GC). This study aimed to investigate the association of five TNF-α polymorphisms including TNF-α-857, TNF-α-1031, TNF-α-863, TNF-α-308, and TNF-α-238 polymorphisms with GC risk.

Methods

All eligible case–control studies were collected by searching PubMed, Scopus, and Web of Science. The association of the risk of GC with TNF-α polymorphisms was estimated using odds ratio (OR) and 95% confidence interval (CI). Heterogeneity was assessed via Cochrane’s Q and I2 analyses.

Results

A total of 46 publications involving 16, 715 cases with GC and 27, 998 controls were recruited. The study revealed a significant association for TNF-α 308 (recessive model: OR = 0.646, P = 0.035), TNF-α-1031 (homozygote model: OR = 1.584, P = 0.027), and TNF-α-857 (homozygote model: OR = 1.760, P = 0.001) polymorphisms with the GC risk. The results of subgroup analysis based ethnicity found a significant association between GC risk and TNF-α-857 polymorphism in Caucasian subgroup (P = 0.005) and TNF-α-1031 polymorphism and GC risk in Asians (P = 0.018).

Conclusions

This study suggested that TNF-α-857 and TNF-α-1031 polymorphisms may be associated with the increased gastric cancer risk.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

source of controls. A TNF-α-857, dominant model. B TNF-α-857, homozygote model. C TNF-α-1031, homozygote model. D TNF-α-863, homozygote model

Similar content being viewed by others

References

  1. Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Przeglad gastroenterologiczny. 2019;14(1):26.

    CAS  PubMed  Google Scholar 

  2. Sultana Z, Bankura B, Pattanayak AK, Sengupta D, Sengupta M, Saha ML, et al. Association of Interleukin-1 beta and tumor necrosis factor-alpha genetic polymorphisms with gastric cancer in India. Environ Mol Mutagen. 2018;59(7):653–67.

    Article  CAS  PubMed  Google Scholar 

  3. Rivas-Ortiz CI, Lopez-Vidal Y, Arredondo-Hernandez, Rene LJ, Castillo-Rojas G. Genetic alterations in gastric cancer associated with Helicobacter pylori infection. Frontiers in medicine. 2017;4:47.

  4. Doaei S, Kalantari N, Mohammadi NK, Izadi P, Salonurmi T, Jarrahi AM, et al. Up-regulation of FTO–gene expression was associated with increase in skeletal muscle mass in overweight male adolescents. Clin Nutr. 2018;37:S16.

    Article  Google Scholar 

  5. Doaei S, Kalantari N, Izadi P, Salonurmi T, Jarrahi AM, Rafieifar S, et al. Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents. Adipocyte. 2019;8(1):386–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ghavami SB, Chaleshi V, Derakhshani S, Aimzadeh P, Asadzadeh-Aghdaie H, Zali MR. Association between TNF-α rs1799964 and RAF1 rs1051208 MicroRNA binding site SNP and gastric cancer susceptibility in an Iranian population. Gastroenterology and Hepatology from Bed to Bench. 2017;10(3):214–9.

    Google Scholar 

  7. Essadik A, Jouhadi H, Rhouda T, Nadifiyine S, Kettani A, Maachi F. Polymorphisms of tumor necrosis factor alpha in moroccan patients with gastric pathology: new single-nucleotide polymorphisms in TNF-alpha(-193) (G/A). Mediat Inflamm. 2015;2015:5.

    Article  CAS  Google Scholar 

  8. Li M, Wang YP, Gu YH. Quantitative assessment of the influence of tumor necrosis factor alpha polymorphism with gastritis and gastric cancer risk. Tumor Biol. 2014;35(2):1495–502.

    Article  CAS  Google Scholar 

  9. Machlowska J, Baj J, Sitarz M, Maciejewski R, Sitarz R. Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Sci. 2020;21(11):4012.

    Article  CAS  PubMed Central  Google Scholar 

  10. Kim J, Lee J, Choi IJ, Kim Y-I, Sung J, Kim J. TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case-control study. Sci Rep. 2020;10(1):14590-.

  11. Zhou P, Lv GQ, Wang JZ, Li CW, Du LF, Zhang C, et al. The TNF-Alpha-238 Polymorphism and Cancer Risk: A Meta-Analysis. PLoS One. 2011;6(7):5.

    Article  Google Scholar 

  12. Zhu F, Zhao H, Tian XH, Meng XJ. Association between tumor necrosis factor-alpha rs1800629 polymorphism and risk of gastric cancer: a meta-analysis. Tumor Biol. 2014;35(3):1799–803.

    Article  CAS  Google Scholar 

  13. Yang JP, Hyun MH, Yoon JM, Park MJ, Kim D, Park S. Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk: a systematic review and meta-analysis. Cytokine. 2014;70(2):104–14.

    Article  CAS  PubMed  Google Scholar 

  14. Thalmaier U, Lehn N, Pfeffer K, Stolte M, Vieth M, Schneider-Brachert W, et al. Role of tumor necrosis factor alpha in Helicobacter pylori gastritis in tumor necrosis factor receptor 1-deficient mice. Infection. 2002;70(6):3149-55.

  15. Bridges SL Jr, Jenq G, Moran M, Kuffner T, Whitworth WC, McNicholl J. Single-nucleotide polymorphisms in tumor necrosis factor receptor genes: definition of novel haplotypes and racial/ethnic differences. Arthritis Rheum. 2002;46(8):2045–50.

    Article  CAS  PubMed  Google Scholar 

  16. Heidari Horestani M, Atri Roozbahani G, Sheidai M. The potential role of TNF-α (rs361525 and rs1800629) in hepatocellular carcinoma: multivariate analysis (meta-analysis). J Gastroin Cancer. 2019;50(4):744–9.

    Article  CAS  Google Scholar 

  17. Waters JP, Pober JS, Bradley JR. Tumour necrosis factor and cancer. J Pathol. 2013;230(3):241–8.

    Article  CAS  PubMed  Google Scholar 

  18. Rudnicka K, Backert S, Chmiela M. Genetic polymorphisms in inflammatory and other regulators in gastric cancer: risks and clinical consequences. molecular mechanisms of inflammation: induction, resolution and escape by helicobacter pylori: Springer; 2019. p. 53–76.

  19. Fargion S, Valenti L, Dongiovanni P, Scaccabarozzi A, Fracanzani AL, Taioli E, et al. Tumor necrosis factor α promoter polymorphisms influence the phenotypic expression of hereditary hemochromatosis. Blood, J Am Society Hema. 2001;97(12):3707–12.

    CAS  Google Scholar 

  20. Valenti L, Fracanzani AL, Dongiovanni P, Santorelli G, Branchi A, Taioli E, et al. Tumor necrosis factor α promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. Gastroenterology. 2002;122(2):274–80.

    Article  CAS  PubMed  Google Scholar 

  21. Zhao HP, Liu LX, Liu B, Wang YM, Li F, Yu HH. An updated association between TNF-alpha-238G/A polymorphism and gastric cancer susceptibility in East Asians. Biosci Rep. 2018;38:13.

    Article  CAS  Google Scholar 

  22. Bounder G, Jouimyi MR, Boura H, Touati E, Michel V, Badre W, et al. Associations of the -238(G/A) and -308(G/A) TNF-α promoter polymorphisms and TNF-α serum levels with the susceptibility to gastric precancerous lesions and gastric cancer related to helicobacter pylori infection in a Moroccan population. Asian Pac J Cancer Prev. 2020;21(6):1623–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Zhu F, Zhao H, Tian X, Meng X. Association between tumor necrosis factor-α rs1800629 polymorphism and risk of gastric cancer: a meta-analysis. Tumour Biol. 2014;35(3):1799–803.

    Article  CAS  PubMed  Google Scholar 

  24. Zhou P, Lv G-Q, Wang J-Z, Li C-W, Du L-F, Zhang C, et al. The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis. PLoS One. 2011;6(7):e22092-e.

  25. Zheng W, Zhang S, Zhang S, Min L, Wang Y, Xie J, et al. The relationship between tumor necrosis factor-α polymorphisms and gastric cancer risk: an updated meta-analysis. Biomed Rep. 2017;7(2):133–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Zhang J, Dou C, Song Y, Ji C, Gu S, Xie Y, et al. Polymorphisms of tumor necrosis factor-alpha are associated with increased susceptibility to gastric cancer: a meta-analysis. J Hum Genet. 2008;53(6):479–89.

    Article  CAS  PubMed  Google Scholar 

  27. Yang JP, Hyun MH, Yoon JM, Park MJ, Kim D, Park S. Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk: a systematic review and meta-analysis. Cytokine. 2014;70(2):104–14.

    Article  CAS  PubMed  Google Scholar 

  28. Xu T, Kong Z, Zhao H. Relationship between tumor necrosis factor-α rs361525 Polymorphism and gastric cancer risk: a meta-analysis. Frontiers in physiology. 2018;9:469-.

  29. Li Z, Zhou G, Mi D, Ma B, Chen L. The association between tumor necrosis factor alpha-308 G/A polymorphism and hepatocellular carsinoma risk: an updated meta-analysis. Acta Medica Mediterranea. 2017;33(6):1007-15. 

  30. Hui M, Yan X, Jiang Y. The tumor necrosis factor-α-238 polymorphism and digestive system cancer risk: a meta-analysis. Clin Exper Med. 2016;16(3):367–74.

    Article  CAS  Google Scholar 

  31. Guo X-F, Wang J, Yu S-J, Song J, Ji M-Y, Cao Z, et al. TNF-α-308 polymorphism and risk of digestive system cancers: a meta-analysis. World J Gastroenterol. 2013;19(48):9461–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Gorouhi F, Islami F, Bahrami H, Kamangar F. Tumour-necrosis factor-A polymorphisms and gastric cancer risk: a meta-analysis. Br J Cancer. 2008;98(8):1443–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Cen G, Wu W. Association between tumor necrosis factor-alpha 857C/T polymorphism and gastric cancer: a meta-analysis. Tumor Biol. 2013;34(6):3383–8.

    Article  CAS  Google Scholar 

  34. Rokkas T, Sechopoulos P, Pistiolas D, Kothonas F, Margantinis G, Koukoulis G. Population differences concerning TNF-α gene polymorphisms in gastric carcinogenesis based on meta-analysis. Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology. 2014;27(2):139.

    Google Scholar 

  35. Yu X, Huang Y, Li CH, Yang HL, Lu CD, Duan SW. Positive association between lymphotoxin-alpha variation rs909253 and cancer risk: a meta-analysis based on 36 case-control studies. Tumor Biol. 2014;35(3):1973–83.

    Article  CAS  Google Scholar 

  36. Xu T, Kong Z, Zhao H. Relationship between tumor necrosis factor-α rs361525 polymorphism and gastric cancer risk: a meta-analysis. Front Physiol. 2018;9(MAY).

  37. Lee SG, Kim B, Yook JH, Oh ST, Lee I, Song K. TNF/LTA polymorphisms and risk for gastric cancer/duodenal ulcer in the Korean population. Cytokine. 2004;28(2):75–82.

    Article  CAS  PubMed  Google Scholar 

  38. Sugimoto M, Furuta T, Shirai N, Nakamura A, Xiao F, Kajimura M, et al. Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer. J Gastroenterol Hepatol. 2007;22(1):51–9.

    Article  CAS  PubMed  Google Scholar 

  39. Yang JJ, Ko KP, Cho LY, Shin A, Gwack J, Chang SH, et al. The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study. BMC Cancer. 2009;9:10.

    Article  CAS  Google Scholar 

  40. Wu MS, Chen LT, Shun CT, Huang SP, Chiu HM, Wang HP, et al. Promoter polymorphisms of tumor necrosis factor-alpha are associated with risk of gastric mucosa-associated lymphoid tissue lymphoma. Int J Cancer. 2004;110(5):695–700.

    Article  CAS  PubMed  Google Scholar 

  41. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–60.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Barbosa HPM, Martins LC, dos Santos SEB, Demachki S, Assumpção MB, Aragão CD, et al. Interleukin-1 and TNF-α polymorphisms and Helicobacter pylori in a Brazilian Amazon population. World J Gastroenterol. 2009;15(12):1465–71.

    Article  CAS  Google Scholar 

  44. Bhayal AG, Krishnaveni D, RangaRao KP, Bogadi V, Suman C, Jyothy A, et al. Role of tumor necrosis factor-α -308 G/A promoter polymorphism in gastric cancer. Saudi Journal of Gastroenterology. 2013;19(4):182–6.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Burada F, Angelescu C, Mitrut P, Ciurea T, Cruce M, Saftoiu A, et al. Interleukin-4 receptor -3223C→T polymorphism is associated with increased gastric adenocarcinoma risk. Can J Gastroenterol. 2012;26(8):532–6.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Canedo P, Duraes C, Pereira F, Regalo G, Lunet N, Barros H, et al. Tumor necrosis factor alpha extended haplotypes and risk of gastric carcinoma. Cancer Epidemiol Biomarkers Prev. 2008;17(9):2416–20.

    Article  CAS  PubMed  Google Scholar 

  47. Crusius JBA, Canzian F, Capellá G, Peña AS, Pera G, Sala N, et al. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Ann Oncol. 2008;19(11):1894–902.

    Article  CAS  PubMed  Google Scholar 

  48. de Oliveira JG, Rossi AFT, Nizato DM, Cadamuro ACT, Jorge YC, Valsechi MC, et al. Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer. Tumor Biol. 2015;36(12):9159–70.

    Article  CAS  Google Scholar 

  49. El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology. 2003;124(5):1193–201.

    Article  CAS  PubMed  Google Scholar 

  50. Fei BY, Xia B, Deng CS, Xia XQ, Xie M, Crusius JBA, et al. Association of tumor necrosis factor genetic polymorphism with chronic atrophic gastritis and gastric adenocarcinoma in Chinese Han population. World J Gastroenterol. 2004;10(9):1256–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Garcia-Gonzalez MA, Lanas A, Quintero E, Nicolas D, Parra-Blanco A, Strunk M, et al. Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a nationwide multicenter study in Spain. Am J Gastroenterol. 2007;102(9):1878–92.

    Article  CAS  PubMed  Google Scholar 

  52. Garza-González E, Bosques-Padilla FJ, El-Omar E, Hold G, Tijerina-Menchaca R, Maldonado-Garza HJ, et al. Role of the polymorphic IL-1B, IL-1RN and TNF-A genes in distal gastric cancer in Mexico. Int J Cancer. 2005;114(2):237–41.

    Article  PubMed  CAS  Google Scholar 

  53. Glas J, Torok HP, Schneider A, Brunnler G, Kopp R, Albert ED, et al. Allele 2 of the interleukin-1 receptor antagonist gene is associated with early gastric cancer. J Clin Oncol. 2004;22(23):4746–52.

    Article  CAS  PubMed  Google Scholar 

  54. Gonzalez-Hormazabal P, Musleh M, Bustamante M, Stambuk J, Escandar S, Valladares H, et al. Role of cytokine gene polymorphisms in gastric cancer risk in Chile. Anticancer Res. 2014;34(7):3523–30.

  55. Guo W, Wang N, Li Y, Zhang JH. Polymorphisms in tumor necrosis factor genes and susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high incidence region of North China. Chin Med J. 2005;118(22):1870–8.

    CAS  PubMed  Google Scholar 

  56. Hong Y, Ge Z, Jing C, Shi J, Dong X, Zhou F, et al. Functional promoter -308G>A variant in tumor necrosis factor α gene is associated with risk and progression of gastric cancer in a Chinese population. PLoS One. 2013;8(1).

  57. Hou L, El-Omar EM, Chen J, Grillo P, Rabkin CS, Baccarelli A, et al. Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancer. Carcinogenesis. 2007;28(1):118–23.

    Article  CAS  PubMed  Google Scholar 

  58. Jang WH, Yang YI, Yea SS, Lee YJ, Chun JH, Kim HI, et al. The-238 tumor necrosis factor-alpha promoter polymorphism is associated with decreased susceptibility to cancers. Cancer Lett. 2001;166(1):41–6.

    Article  CAS  PubMed  Google Scholar 

  59. Jiang LP, Wang JM, Gao X, Liu SZ. Association of TNF-alpha, TNFRSF1A and TNFRSF1B gene polymorphisms with the risk of gastric cancer in Chinese population. Int J Clin Exp Med. 2017;10(8):12483–91.

    Google Scholar 

  60. Kamangar F, Abnet CC, Hutchinson AA, Newschaffer CJ, Helzlsouer K, Shugart YY, et al. Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control. 2006;17(1):117–25.

    Article  PubMed  Google Scholar 

  61. Kim N, Cho SI, Yim JY, Kim JM, Lee DH, Park JH, et al. The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea. Helicobacter. 2006;11(2):105–12.

    Article  CAS  PubMed  Google Scholar 

  62. Lee JY, Kim HY, Kim KH, Kim SM, Jang MK, Park JY, et al. Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea. Cancer Lett. 2005;225(2):207–14.

    Article  CAS  PubMed  Google Scholar 

  63. Li C, Xia B, Yang Y, Jin L, Xia HHX. TNF gene polymorphisms and Helicobacter pylori infection in gastric carcinogenesis in Chinese population. Am J Gastroenterol. 2005;100(2):290–4.

    Article  CAS  PubMed  Google Scholar 

  64. Lu WL, Pan KF, Zhang L, Lin DX, Miao XP, You WC. Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor alpha and risk of gastric cancer in a Chinese population. Carcinogenesis. 2005;26(3):631–6.

    Article  CAS  PubMed  Google Scholar 

  65. Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, et al. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology. 2003;125(2):364–71.

    Article  CAS  PubMed  Google Scholar 

  66. Morgan DR, Dominguez RL, Keku TO, Heidt PE, Martin CF, Galanko JA, et al. Gastric cancer and the high combination prevalence of host cytokine genotypes and helicobacter pylori in Honduras. Clin Gastroenterol Hepatol. 2006;4(9):1103–11.

    Article  CAS  PubMed  Google Scholar 

  67. Perri F, Piepoli A, Bonvicini C, Gentile A, Quitadamo M, Di Candia M, et al. Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence. Cytokine. 2005;30(5):293–302.

    Article  CAS  PubMed  Google Scholar 

  68. Rocha GA, Guerra JB, Rocha AMC, Saraiva IEB, da Silva DA, de Oliveira CA, et al. IL1RN polymorphic gene and cagA-positive status independently increase the risk of noncardia gastric carcinoma. Int J Cancer. 2005;115(5):678–83.

    Article  CAS  PubMed  Google Scholar 

  69. Stubljar D, Jeverica S, Jukic T, Skvarc M, Pintar T, Tepes B, et al. The influence of cytokine gene polymorphisms on the risk of developing gastric cancer in patients with Helicobacter pylori infection. Radiol Oncol. 2015;49(3):256–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Whiteman DC, Parmar P, Fahey P, Moore SP, Stark M, Zhao ZZ, et al. Association of Helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiers. Gastroenterology. 2010;139(1):73–83.

    Article  CAS  PubMed  Google Scholar 

  71. Won JH, Song JH, Kang YH, Park YK, Cao Z, Nam SW, et al. TNF-alpha and TNF-beta polymorphisms with susceptibility to gastric cancer in a Korean population. Mol Cell Toxicol. 2010;6(2):161–7.

    Article  CAS  Google Scholar 

  72. Wu MS, Huang SP, Chang YT, Shun CT, Chang MC, Lin MT, et al. Tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma. J Infect Dis. 2002;185(1):106–9.

    Article  CAS  PubMed  Google Scholar 

  73. Wu MS, Wu CY, Chen CJ, Lin MT, Shun CT, Lin JT. Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese. Int J Cancer. 2003;104(5):617–23.

    Article  CAS  PubMed  Google Scholar 

  74. Xu Y, Cao X, Jiang J, Chen Y, Wang K. TNF-α-308/-238 polymorphisms are associated with gastric cancer: a case-control family study in China. Clin Res Hepatol Gastroenterol. 2017;41(1):103–9.

    Article  CAS  PubMed  Google Scholar 

  75. Zambon CF, Basso D, Navaglia F, Belluco C, Falda A, Fogar P, et al. Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. Cytokine. 2005;29(4):141–52.

    Article  CAS  PubMed  Google Scholar 

  76. Yuan LJ, Jin TB, Yin JK, Du XL, Wang Q, Dong R, et al. Polymorphisms of tumor-related genes IL-10, PSCA, MTRR and NOC3L are associated with the risk of gastric cancer in the Chinese Han population. Cancer Epidemiol. 2012;36(6):E366–72.

    Article  CAS  PubMed  Google Scholar 

  77. You WX, Lai XF, Lv J, Chen P, Xia JR, Cui F, et al. Association of tumor necrosis factor-alpha gene polymorphisms with susceptibility to helicobacter pylori-associated gastroduodenal diseases in the Chinese population. Int J Clin Exp Pathol. 2016;9(12):12836–42.

    CAS  Google Scholar 

  78. De Oliveira JG, Rossi AFT, Nizato DM, Miyasaki K, Silva AE. Profiles of gene polymorphisms in cytokines and toll-like receptors with higher risk for gastric cancer. Dig Dis Sci. 2013;58(4):978–88.

    Article  CAS  PubMed  Google Scholar 

  79. Shirai K, Ohmiya N, Taguchi A, Mabuchi N, Yatsuya H, Itoh A, et al. Interieukin-8 gene polymorphism associated with susceptibility to non-cardia gastric carcinoma with microsatellite instability. J Gastroenterol Hepatol. 2006;21(7):1129–35.

    Article  CAS  PubMed  Google Scholar 

  80. Ohyama I, Ohmiya N, Niwa Y, Shirai K, Taguchi A, Itoh A, et al. The association between tumour necrosis factor-alpha gene polymorphism and the susceptibility to rugal hyperplastic gastritis and gastric carcinoma. Eur J Gastroenterol Hepatol. 2004;16(7):693–700.

    Article  CAS  PubMed  Google Scholar 

  81. Abdi E, Latifi-Navid S, Zahri S, Kholghi-Oskooei V, Mostafaiy B, Yazdanbod A, et al. SNP-SNP interactions of oncogenic long non-coding RNAs HOTAIR and HOTTIP on gastric cancer susceptibility. Sci Rep. 2020;10(1):1–12.

    Article  CAS  Google Scholar 

  82. Zheng W, Wu C, Wu X, Cai Y, Liu B, Wang C. Genetic variants of autophagy-related genes in the PI3K/Akt/mTOR pathway and risk of gastric cancer in the Chinese population. Gene. 2021;769:145190.

  83. Kim J, Kim H, Lee J, Choi IJ, Kim Y-I, Kim J. Antioxidant-rich diet, GSTP1 rs1871042 polymorphism, and gastric cancer risk in a hospital-based case-control study. Front Oncol. 2021;10:3240.

    Article  Google Scholar 

  84. Qidwai T, Khan F. Tumour necrosis factor gene polymorphism and disease prevalence. Scand J Immunol. 2011;74(6):522–47.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Yi F, Shi X, Pei X, Wu X. Tumor necrosis factor-alpha-308 gene promoter polymorphism associates with survival of cancer patients: a meta-analysis. Medicine. 2018;97(45):e13160.

  86. Wang X, Lin Y. Tumor necrosis factor and cancer, buddies or foes? Acta Pharmacol Sin. 2008;29(11):1275–88.

    Article  PubMed  CAS  Google Scholar 

  87. Oshima H, Ishikawa T, Yoshida G, Naoi K, Maeda Y, Naka K, et al. TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. Oncogene. 2014;33(29):3820–9.

    Article  CAS  PubMed  Google Scholar 

  88. Hui M, Yan XJ, Jiang Y. The tumor necrosis factor-alpha-238 polymorphism and digestive system cancer risk: a meta-analysis. Clin Exper Med. 2016;16(3):367–74.

    Article  CAS  Google Scholar 

  89. Zhang JY, Dou C, Song YT, Ji CN, Gu SH, Xie Y, et al. Polymorphisms of tumor necrosis factor-alpha are associated with increased susceptibility to gastric cancer: a meta-analysis. J Hum Genet. 2008;53(6):479–89.

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

Funding for the work originated from the National Nutrition and Food Technology Research Institute (NNFTRI), Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the project NO. 27877).

Author information

Authors and Affiliations

  1. Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Maryam Gholamalizadeh

  2. Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran

    Samaneh Mirzaei Dahka

  3. Razi Clinical Research Development Unit, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran

    Hadi Sedigh Ebrahim-Saraie

  4. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Esmail Akbari & Saied Doaei

  5. School of Medicine, Mashhad University of Medical Sciences, Tehran, Iran

    Azam Pourtaheri

  6. Department of Clinical Nutrition and Dietetics, Research Institute Shahid Beheshti University of Medical Science, Tehran, Iran

    Samira Rastgoo

  7. M.Sc. Student of Health Sciences in Nutrition, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran

    Azadeh Hajipour

  8. Caspian Digestive Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran

    Afshin Shafaghi & Saied Doaei

  9. Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Naser Kalantari

Authors
  1. Maryam Gholamalizadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Samaneh Mirzaei Dahka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hadi Sedigh Ebrahim-Saraie
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mohammad Esmail Akbari
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Azam Pourtaheri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Samira Rastgoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Azadeh Hajipour
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Afshin Shafaghi
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Saied Doaei
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Naser Kalantari
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

SD, HSE, MGH, NK, SM, and SR designed the study and involved in the data collection, analysis, and drafting of the manuscript. AH, MEA, AP, AH, and ASH were involved in the design of the study and analysis of the data and critically reviewed the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Saied Doaei or Naser Kalantari.

Ethics declarations

Ethics Approval and Consent to Participate

The study was approved by the Shahid Beheshti University of Medical Sciences, Tehran, Iran (ethical code: IR.SBMU.NNFTRI.REC.1400.021).

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 12888 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gholamalizadeh, M., Mirzaei Dahka, S., Sedigh Ebrahim-Saraie, H. et al. The Role of Tumor Necrosis Factor-α (TNF-α) Polymorphisms in Gastric Cancer: a Meta-Analysis. J Gastrointest Canc 53, 756–769 (2022). https://doi.org/10.1007/s12029-021-00688-w

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-021-00688-w

Keywords

Search

Navigation