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Association between tumor necrosis factor-alpha 857C/T polymorphism and gastric cancer: a meta-analysis

  • Research Article
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Tumor Biology

Abstract

Tumor necrosis factor-alpha (TNF-α) is an inflammatory cytokine which may play an important role on the immune response may control the progression of gastric cancer. Previous studies on the association between TNF-α 857C/T polymorphism and gastric cancer risk reported conflicting results. We performed a meta-analysis to comprehensively assess the association between TNF-α 857C/T polymorphism and gastric cancer risk. Literature search was performed for all publications on the association between TNF-α 857C/T polymorphism and gastric cancer risk through March 6, 2013. The pooled odds ratios (ORs) with their 95 % confidence interval (95 %CIs) were calculated to assess the association between TNF-α 857C/T polymorphism and gastric cancer risk. Nine individual case–control studies with a total of 5,054 subjects (1,835 cases and 3,219 controls) were finally included into the meta-analysis. Meta-analysis of total nine studies showed that TNF-α 857C/T polymorphism was significantly associated with increased risk of gastric cancer under four genetic models (for T vs. C: OR = 1.19, 95 %CI 1.07–1.33, P = 0.002; for TT vs. CC: OR = 1.44, 95 %CI 1.03–2.02, P = 0.032; for CT vs. CC: OR = 1.19, 95 %CI 1.05–1.36, P = 0.008; and for TT/CT vs. CC: OR = 1.21, 95 %CI 1.07–1.38, P = 0.003). Subgroup analysis by ethnicity further showed that there was a significant association between TNF-α 857C/T polymorphism and increased risk of gastric cancer in Asians but not in Caucasians. The meta-analysis suggests that TNF-α 857C/T polymorphism is significantly associated with increased risk of gastric cancer, especially in Asians.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Affiliated First People’s Hospital, Shanghai Jiao Tong University, 100 Hai Ning Road, Shanghai, 200080, China

    Gang Cen

  2. Department of General Surgery, Affiliated First People’s Hospital, Shanghai Jiao Tong University, 100 Hai Ning Road, Shanghai, 200080, China

    Weidong Wu

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  1. Gang Cen
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Correspondence to Weidong Wu.

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Cen, G., Wu, W. Association between tumor necrosis factor-alpha 857C/T polymorphism and gastric cancer: a meta-analysis. Tumor Biol. 34, 3383–3388 (2013). https://doi.org/10.1007/s13277-013-0910-0

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  • DOI: https://doi.org/10.1007/s13277-013-0910-0

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