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The tumor necrosis factor-α-238 polymorphism and digestive system cancer risk: a meta-analysis

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Abstract

Many studies have reported the association between tumor necrosis factor-α (TNF-α)-238 polymorphism and digestive system cancer susceptibility, but the results were inconclusive. We performed a meta-analysis to derive a more precise estimation of the relationship between TNF-α-238 G/A polymorphism and digestive system cancer risk. Pooled analysis for the TNF-α-238 G/A polymorphism contained 26 studies with a total of 4849 cases and 8567 controls. The meta-analysis observed a significant association between TNF-α-238 G/A polymorphism and digestive system cancer risk in the overall population (GA vs GG: OR 1.19, 95 % CI 1.00–1.40, P heterpgeneity = 0.016; A vs G: OR 1.19, 95 % CI 1.03–1.39, P heterpgeneity = 0.015; dominant model: OR 1.20, 95 % CI 1.02–1.41, P heterpgeneity = 0.012). In the analysis of the ethnic subgroups, however, similar results were observed only in the Asian population, but not in the Caucasian population. Therefore, this meta-analysis suggests that TNF-α-238 G/A polymorphism is associated with a significantly increased risk of digestive system cancer. Further large and well-designed studies are needed to confirm these findings.

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Authors and Affiliations

  1. Department of Gastroenterology, The Second Affiliated Hospital of Xinjiang Medical University, Urumchi, 830011, China

    Ming Hui

  2. Department of Emergency, Urumchi First People’s Hospital, Urumchi, 830000, China

    Xiaojuan Yan

  3. Department of Infectious Diseases, The Second Affiliated Hospital of Xinjiang Medical University, Urumchi, 830011, China

    Ying Jiang

  4. Department of Infectious Diseases, The Second Affiliated Hospital of Xinjiang Medical University, No. 38, Lane 2, Nanhu East Road, Urumchi, 830000, China

    Ying Jiang

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  1. Ming Hui
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Correspondence to Ying Jiang.

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Hui, M., Yan, X. & Jiang, Y. The tumor necrosis factor-α-238 polymorphism and digestive system cancer risk: a meta-analysis. Clin Exp Med 16, 367–374 (2016). https://doi.org/10.1007/s10238-015-0363-4

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  • DOI: https://doi.org/10.1007/s10238-015-0363-4

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