Skip to main content

Advertisement

SpringerLink
Log in

Association between tumor necrosis factor-α rs1800629 polymorphism and risk of gastric cancer: a meta-analysis

  • Research Article
  • Published:
Tumor Biology

Abstract

Gastric cancer is mainly initiated by inflammation and chronic superficial gastritis, and tumor necrosis factor-α (TNF-α) is an inflammatory cytokine which plays an important role in the inflammation. TNF-α rs1800629 G/A polymorphism was proposed to be associated with gastric cancer risk, but previous studies on Caucasians reported conflicting results. We performed a meta-analysis to comprehensively assess the association between TNF-α rs1800629 polymorphism and gastric cancer risk in Caucasians. The pooled odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated to assess the association. Eleven case–control studies with 7,427 subjects were finally included into the meta-analysis. Overall, TNF-α rs1800629 polymorphism was significantly associated with the increased risk of gastric cancer under four genetic comparison models (A versus G: OR = 1.32, 95 % CI 1.12–1.56, P = 0.001; AA versus GG: OR = 1.76, 95 % CI 1.37–2.26, P < 0.001; AA versus GG/GA: OR = 1.62, 95 % CI 1.27–2.07, P < 0.001; AA/GA versus GG: OR = 1.35, 95 % CI 1.14–1.60, P = 0.001). Meta-analysis of those studies with high quality showed that TNF-α rs1800629 polymorphism was still significantly associated with the increased risk of gastric cancer under four genetic comparison models. There was no risk of publication bias in the meta-analysis. The meta-analysis suggests that TNF-α rs1800629 polymorphism is associated with the increased risk of gastric cancer in Caucasians.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Hartgrink HH, Jansen EP, van Grieken NC, van de Velde CJ. Gastric cancer. Lancet. 2009;374:477–90.

    Article  PubMed  Google Scholar 

  2. Siegel R, Naishadham D, Jemal A. Cancer statistic. CA Cancer J Clin. 2012;62:10–29.

    Article  PubMed  Google Scholar 

  3. Houghton J, Wang TC. Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology. 2005;128:1567–78.

    Article  PubMed  CAS  Google Scholar 

  4. Merchant JL. Inflammation, atrophy, gastric cancer: connecting the molecular dots. Gastroenterology. 2005;129:1079–82.

    Article  PubMed  CAS  Google Scholar 

  5. Dong LM, Potter JD, White E, Ulrich CM, Cardon LR, Peters U. Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA. 2008;299:2423–36.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  6. Wroblewski LE, Peek Jr RM. Helicobacter pylori in gastric carcinogenesis: mechanisms. Gastroenterol Clin North Am. 2013;42:285–98.

    Article  PubMed  Google Scholar 

  7. Chu WM. Tumor necrosis factor. Cancer Lett. 2013;328:222–5.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  8. Vendramini-Costa DB, Carvalho JE. Molecular link mechanisms between inflammation and cancer. Curr Pharm Des. 2012;18:3831–52.

    Article  PubMed  CAS  Google Scholar 

  9. Fargion S, Valenti L, Dongiovanni P, Scaccabarozzi A, Fracanzani AL, Taioli E, et al. Tumor necrosis factor alpha promoter polymorphisms influence the phenotypic expression of hereditary hemochromatosis. Blood. 2001;97:3707–12.

    Article  PubMed  CAS  Google Scholar 

  10. Valenti L, Fracanzani AL, Dongiovanni P, Santorelli G, Branchi A, Taioli E, et al. Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. Gastroenterology. 2002;122:274–80.

    Article  PubMed  CAS  Google Scholar 

  11. Abraham LJ, Kroeger KM. Impact of the −308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease. J Leukoc Biol. 1999;66:562–6.

    PubMed  CAS  Google Scholar 

  12. Bayley JP, Ottenhoff TH, Verweij CL. Is there a future for TNF promoter polymorphisms? Genes Immun. 2004;5:315–29.

    Article  PubMed  CAS  Google Scholar 

  13. Kamangar F, Abnet CC, Hutchinson AA, Newschaffer CJ, Helzlsouer K, Shugart YY, et al. Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control. 2006;17:117–25.

    Article  PubMed  Google Scholar 

  14. Canedo P, Duraes C, Pereira F, Regalo G, Lunet N, Barros H, et al. Tumor necrosis factor alpha extended haplotypes and risk of gastric carcinoma. Cancer Epidemiol Biomarkers Prev. 2008;17:2416–20.

    Article  PubMed  CAS  Google Scholar 

  15. Hou L, El-Omar EM, Chen J, Grillo P, Rabkin CS, Baccarelli A, et al. Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancer. Carcinogenesis. 2007;28:118–23.

    Article  PubMed  CAS  Google Scholar 

  16. Morgan DR, Dominguez RL, Keku TO, Heidt PE, Martin CF, Galanko JA, et al. Gastric cancer and the high combination prevalence of host cytokine genotypes and helicobacter pylori in Honduras. Clin Gastroenterol Hepatol. 2006;4:1103–11.

    Article  PubMed  CAS  Google Scholar 

  17. Perri F, Piepoli A, Bonvicini C, Gentile A, Quitadamo M, Di Candia M, et al. Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence. Cytokine. 2005;30:293–302.

    Article  PubMed  CAS  Google Scholar 

  18. Zambon CF, Basso D, Navaglia F, Belluco C, Falda A, Fogar P, et al. Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. Cytokine. 2005;29:141–52.

    Article  PubMed  CAS  Google Scholar 

  19. El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology. 2003;124:1193–201.

    Article  PubMed  CAS  Google Scholar 

  20. Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, et al. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology. 2003;125:364–71.

    Article  PubMed  CAS  Google Scholar 

  21. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    PubMed  CAS  Google Scholar 

  23. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  PubMed  CAS  Google Scholar 

  24. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  25. Garcia-Gonzalez MA, Lanas A, Quintero E, Nicolas D, Parra-Blanco A, Strunk M, et al. Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a nationwide multicenter study in Spain. Am J Gastroenterol. 2007;102:1878–92.

    Article  PubMed  CAS  Google Scholar 

  26. Crusius JB, Canzian F, Capella G, Pena AS, Pera G, Sala N, et al. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Ann Oncol. 2008;19:1894–902.

    Article  PubMed  CAS  Google Scholar 

  27. Burada F, Angelescu C, Mitrut P, Ciurea T, Cruce M, Saftoiu A, et al. Interleukin-4 receptor -3223T→C polymorphism is associated with increased gastric adenocarcinoma risk. Can J Gastroenterol. 2012;26:532–6.

    PubMed Central  PubMed  Google Scholar 

  28. Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009;9:361–71.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgment

This work was supported by the funding from NSFC (81072007).

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200097, China

    Feng Zhu, Hang Zhao, Xiaohui Tian & Xiangjun Meng

Authors
  1. Feng Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hang Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiaohui Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xiangjun Meng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiangjun Meng.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhu, F., Zhao, H., Tian, X. et al. Association between tumor necrosis factor-α rs1800629 polymorphism and risk of gastric cancer: a meta-analysis. Tumor Biol. 35, 1799–1803 (2014). https://doi.org/10.1007/s13277-013-1240-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-013-1240-y

Keywords

Search

Navigation