Recent advances in the discovery of bioactive metabolites from Pestalotiopsis
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Fungal endophytes have marked a significant impact on drug discovery reducing the burden and dependency on plants. The vast diversity of Pestalotiopsis sp. has emerged as promising source of wide range of bioactive natural compounds. Recently a series of numerous novel secondary metabolites have been discovered of which taxol has drawn attention of scientific community towards its medicinal potential. A wide variety of compounds like alkaloids, polyketides, terpenoids, flavonoids, coumarins, xanthones, quinones, semiquinones, peptides, phenols, phenolic acids, and lactones have been identified which have usage as antimicrobial, antifungal, antiviral antoneoplastic, and antioxidant activities. This review aims to highlight recent discoveries of different strains of Pestalotiopsis identified for producing natural bioactive compounds along with insights of their source of origin and potential in biotechnological applications.
KeywordsPestalotiopsis Endophytes Drug discovery Natural products Anticancer agents Taxol
Authors are thankful to Dr. Alok Adholeya, Senior Director, Biotechnology and Bioresouces Division, The Energy and Resources Institute, Darbari Seth Block, IHC Complex, Lodhi Road, New Delhi, India, for help and continuous support.
SKD, VP, and NR reviewed the contents critically. VP and NR drew chemical structures and assisted in the preparation of Table 2. SKD and NR wrote the review.
- Bi J, Ji Y, Pan J, Yu Y, Chen H, Zhu X (2011) A new taxol-producing fungus (Pestalotiopsis malicola) and evidence for taxol as a transient product in the culture. Afr J Biotechnol 10(34):6647–6654Google Scholar
- Gangadevi V, Murugan M, Muthumary J (2008) Taxol determination from Pestalotiopsis pauciseta, a fungal endophyte of a medicinal plant. Shengwu Gongcheng Xuebao 24(8):1433–1438Google Scholar
- Karthik G, Govindarajan K, Natarajapillai S (2012) Production of taxol by Pestalotiopsis breviseta CR01 isolated from the Catharanceus roceus and its growth studies. Int J Pharma Bio Sci 3(3):1046–1053Google Scholar
- Kathiravan G, Sri Raman V, Rajangam B, Rajasekar A (2014) Infra-red spectral analysis of taxol produced by different species of Pestalotiopsis. J Anal Bioanal Tech 5(4):1000205/1–1000205/9Google Scholar
- Li ZZ, Yang XL (2014) Cytotoxic secondary metabolites from liquid culture of plant endophytic fungus Pestalotiopsis virgatula. Junwu Xuebao 33(1):97–102Google Scholar
- Li X, Guo Z, Deng Z, Yang J, Zou K (2015a) A new α-pyrone derivative from endophytic fungus Pestalotiopsis microspora. Rec Nat Prod 9(4):503–508Google Scholar
- Liu S, Liu L (2010) Isoprenylated chromones from the plant endophytic fungus Pestalotiopsis fici. Junwu Xuebao 29(4):582–587Google Scholar
- Liu SC, Ye X, Guo LD, Liu L (2011a) Cytotoxic isoprenylated epoxycyclohexanediols from the plant endophyte Pestalotiopsis fici. Zhongguo Tianran Yaowu 9(5):374–379Google Scholar
- Liu L, Zhao C, Li L, Guo L, Che Y (2015) Pestalotriols A and B, new spiro[2.5]octane derivatives from the endophytic fungus Pestalotiopsis fici RSC. Advances 5(96):78708–78711Google Scholar
- Muthumary J, Sashirekha S (2007) Detection of taxol, an anticancer drug, from selected coelomycetous fungi. Indian J Sci Technol 1(1):1–10Google Scholar
- Srinivasan K, Muthumary J (2009) Taxol production from Pestalotiopsis sp. an endophytic fungus isolated from Catharanthus roseus. J Ecobiotechnol 1:28–31Google Scholar
- Sun JF, Lin X, Zhou XF, Wan J, Zhang T, Yang B, Yang XW, Tu Z, Liu Y (2014) Pestalols A-E, new alkenyl phenol and benzaldehyde derivatives from endophytic fungus Pestalotiopsis sp. AcBC2 isolated from the Chinese mangrove plant Aegiceras corniculatum. J Antibiot 67(6):451–457PubMedCrossRefGoogle Scholar
- Yang XL, Zhang S, Song SJ, Zhang Y, Luo DQ, Zhang M (2011b) A new biphenyl from the fermentation broth of plant endophytic fungus Pestalotiopsis zonata isolated from Cyrtotachys lakka. Zhongguo Tianran Yaowu 9(2):101–104Google Scholar