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Phytochemistry Reviews

, Volume 16, Issue 5, pp 883–920 | Cite as

Recent advances in the discovery of bioactive metabolites from Pestalotiopsis

  • Sunil Kumar Deshmukh
  • Ved Prakash
  • Nihar Ranjan
Article

Abstract

Fungal endophytes have marked a significant impact on drug discovery reducing the burden and dependency on plants. The vast diversity of Pestalotiopsis sp. has emerged as promising source of wide range of bioactive natural compounds. Recently a series of numerous novel secondary metabolites have been discovered of which taxol has drawn attention of scientific community towards its medicinal potential. A wide variety of compounds like alkaloids, polyketides, terpenoids, flavonoids, coumarins, xanthones, quinones, semiquinones, peptides, phenols, phenolic acids, and lactones have been identified which have usage as antimicrobial, antifungal, antiviral antoneoplastic, and antioxidant activities. This review aims to highlight recent discoveries of different strains of Pestalotiopsis identified for producing natural bioactive compounds along with insights of their source of origin and potential in biotechnological applications.

Keywords

Pestalotiopsis Endophytes Drug discovery Natural products Anticancer agents Taxol 

Notes

Acknowledgement

Authors are thankful to Dr. Alok Adholeya, Senior Director, Biotechnology and Bioresouces Division, The Energy and Resources Institute, Darbari Seth Block, IHC Complex, Lodhi Road, New Delhi, India, for help and continuous support.

Author contributions

SKD, VP, and NR reviewed the contents critically. VP and NR drew chemical structures and assisted in the preparation of Table 2. SKD and NR wrote the review.

References

  1. Arunpanichlert J, Rukachaisirikul V, Phongpaichit S, Supaphon O, Sakayaroj J (2015) Meroterpenoid, isocoumarin, and phenol derivatives from the seagrass-derived fungus Pestalotiopsis sp. PSU-ES194. Tetrahedron 71(5):882–888CrossRefGoogle Scholar
  2. Bi J, Ji Y, Pan J, Yu Y, Chen H, Zhu X (2011) A new taxol-producing fungus (Pestalotiopsis malicola) and evidence for taxol as a transient product in the culture. Afr J Biotechnol 10(34):6647–6654Google Scholar
  3. Chaires JB (2005) Competition dialysis: an assay to measure the structural selectivity of drug-nucleic acid interactions. Curr Med Chem Anti-Cancer Agents 5:339–352PubMedCrossRefGoogle Scholar
  4. Chen C, Yang RL (2013) A phthalide derivative isolated from endophytic fungi Pestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells. Braz J Med Biol Res 46(8):643–649PubMedPubMedCentralCrossRefGoogle Scholar
  5. Chen C, Hu SY, Luo DQ, Zhu SY, Zhou CQ (2013) Potential antitumor agent from the endophytic fungus Pestalotiopsis photiniae induces apoptosis via the mitochondrial pathway in HeLa cells. Oncol Rep 30(4):1773–1781PubMedCrossRefGoogle Scholar
  6. Davis RA, Carroll AR, Andrews KT, Boyle GM, Tran TL, Healy PC, Kalaitzis JA, Shivas RG (2010) Pestalactams A-C: novel caprolactams from the endophytic fungus Pestalotiopsis sp. Org Biomol Chem 8(8):1785–1790PubMedCrossRefGoogle Scholar
  7. Ding G, Liu S, Guo L, Zhou Y, Che Y (2008a) Antifungal metabolites from the plant endophytic fungus Pestalotiopsis foedans. J Nat Prod 71(4):615–618PubMedCrossRefGoogle Scholar
  8. Ding G, Jiang L, Guo L, Chen X, Zhang H, Che Y (2008b) Pestalazines and pestalamides, bioactive metabolites from the plant pathogenic fungus Pestalotiopsis theae. J Nat Prod 71(11):1861–1865PubMedCrossRefGoogle Scholar
  9. Ding G, Zheng Z, Liu S, Zhang H, Guo L, Che Y (2009a) Photinides A-F, cytotoxic benzofuranone-derived γ-lactones from the plant endophytic fungus Pestalotiopsis photiniae. J Nat Prod 72(5):942–945PubMedCrossRefGoogle Scholar
  10. Ding G, Li Y, Fu S, Liu S, Wei J, Che Y (2009b) Ambuic acid and torreyanic acid derivatives from the endolichenic fungus Pestalotiopsis sp. J Nat Prod 72(1):182–186PubMedCrossRefGoogle Scholar
  11. Ding G, Zhang F, Chen H, Guo L, Zou Z, Che Y (2011) Pestaloquinols A and B, isoprenylated epoxyquinols from Pestalotiopsis sp. J Nat Prod 74(2):286–291PubMedCrossRefGoogle Scholar
  12. Ding G, Qi Y, Liu S, Guo L, Chen X (2012) Photipyrones A and B, new pyrone derivatives from the plant endophytic fungus Pestalotiopsis photiniae. J Antibiot 65(5):271–273PubMedCrossRefGoogle Scholar
  13. Gangadevi V, Muthumary J (2008) A simple and rapid method for the determination of taxol produced by fungal endophytes from medicinal plants using high performance thin layer chromatography. Se Pu 26(1):50–55PubMedGoogle Scholar
  14. Gangadevi V, Muthumary J (2009) Taxol production by Pestalotiopsis terminaliae, an endophytic fungus of Terminalia arjuna (arjun tree). Biotechnol Appl Biochem 52(1):9–15PubMedCrossRefGoogle Scholar
  15. Gangadevi V, Murugan M, Muthumary J (2008) Taxol determination from Pestalotiopsis pauciseta, a fungal endophyte of a medicinal plant. Shengwu Gongcheng Xuebao 24(8):1433–1438Google Scholar
  16. Gu Y, Wang Y, Ma X, Wang C, Yue G, Zhang Y, Zhang Y, Li S, Ling S, Liu X et al (2015) Greater taxol yield of fungus Pestalotiopsis hainanensis from dermatitic scurf of the giant panda (Ailuropoda melanoleuca). Appl Biochem Biotechnol 175(1):155–165PubMedCrossRefGoogle Scholar
  17. Harper JK, Arif AM, Ford EJ, Strobel GA, Porco JA, Tomer DP, Oneill KL, Heider EM, Grant DM (2003) Pestacin: a 1,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antioxidant and antimycotic activities. Tetrahedron 59(14):2471–2476CrossRefGoogle Scholar
  18. Hemberger Y, Xu J, Wray V, Proksch P, Wu J, Bringmann G (2013) Pestalotiopens A and B: stereochemically challenging flexible sesquiterpene-cyclopaldic acid hybrids from Pestalotiopsis sp. Chem---Eur J 19(46):15556–15564PubMedCrossRefGoogle Scholar
  19. Jeewon R, Liew ECY, Simpson JA, Hodgkiss IJ, Hyde KD (2003) Phylogenetic significance of morphological characters in the taxonomy of Pestalotiopsis species. Mol Phylogenet Evol 27:372–383PubMedCrossRefGoogle Scholar
  20. Jia YL, Guan FF, Ma J, Wang CY, Shao CL (2015a) Pestalotiolide A, a new antiviral phthalide derivative from a soft coral-derived fungus Pestalotiopsis sp. Nat Prod Sci 21(4):227–230CrossRefGoogle Scholar
  21. Jia YL, Wei MY, Chen HY, Guan FF, Wang CY, Shao CL (2015b) (+)- and (−)-Pestaloxazine A, a pair of antiviral enantiomeric alkaloid dimers with a symmetric spiro[oxazinane-piperazinedione] skeleton from Pestalotiopsis sp. Org Lett 17(17):4216–4219PubMedCrossRefGoogle Scholar
  22. Jordan MA, Toso RJ, Thrower D, Wilson L (1993) Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci USA 90:9552–9556PubMedPubMedCentralCrossRefGoogle Scholar
  23. Karthik G, Govindarajan K, Natarajapillai S (2012) Production of taxol by Pestalotiopsis breviseta CR01 isolated from the Catharanceus roceus and its growth studies. Int J Pharma Bio Sci 3(3):1046–1053Google Scholar
  24. Kathiravan G, Sri Raman V (2010) In vitro Taxol production, by Pestalotiopsis breviseta—a first report. Fitoterapia 81(6):557–564PubMedCrossRefGoogle Scholar
  25. Kathiravan G, Sureban SM (2009) Effect of taxol from Pestalotiopsis mangiferae on A549 cells-In vitro study. J Basic Clin Pharm 1(1):1–9PubMedGoogle Scholar
  26. Kathiravan G, Sri Raman V, Rajangam B, Rajasekar A (2014) Infra-red spectral analysis of taxol produced by different species of Pestalotiopsis. J Anal Bioanal Tech 5(4):1000205/1–1000205/9Google Scholar
  27. Kumaran RS, Kim HJ, Hui BK (2010) Taxol-producing fungal endophyte, Pestalotiopsis species isolated from Taxus cuspidata. J Biosci Bioeng 110(5):541–546PubMedCrossRefGoogle Scholar
  28. Lee JC, Yang X, Schwartz M, Strobel GA, Clardy J (1995) The relationship between an endangered North America tree and an endophytic fungus. Chem Biol 2(11):721–727PubMedCrossRefGoogle Scholar
  29. Lee JC, Strobel GA, Lobkovsky E, Clardy J (1996) Torreyanic acid: a selectively cytotoxic quinone dimer from the endophytic fungus Pestalotiopsis microspora. J Org Chem 61(10):3232–3233CrossRefGoogle Scholar
  30. Li JY, Strobel GA (2001) Jesterone and hydroxy-jesterone antioomycete cyclohexenone epoxides from the endophytic fungus Pestalotiopsis jesteri. Phytochemistry 57(2):261–265PubMedCrossRefGoogle Scholar
  31. Li ZZ, Yang XL (2014) Cytotoxic secondary metabolites from liquid culture of plant endophytic fungus Pestalotiopsis virgatula. Junwu Xuebao 33(1):97–102Google Scholar
  32. Li J, Strobel G, Sidhu R, Hess WM, Ford EJ (1996) Endophytic taxol producing fungi from bald cypress Taxodium distichum. Microbiology 142:2223–2226PubMedCrossRefGoogle Scholar
  33. Li JY, Harper JK, Grant DM, Tombe BO, Bashyal B, Hess WM, Strobel GA (2001) Ambuic acid, a highly functionalized cyclohexenone with antifungal activity from Pestalotiopsis spp. and Monochaetia sp. Phytochemistry 56(5):463–468PubMedCrossRefGoogle Scholar
  34. Li E, Jiang L, Guo L, Zhang H, Che Y (2008a) Pestalachlorides A-C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta. Bioorg Med Chem 16(17):7894–7899PubMedCrossRefGoogle Scholar
  35. Li E, Tian R, Liu S, Chen X, Guo L, Che Y (2008b) Pestalotheols A-D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae. J Nat Prod 71(4):664–668PubMedCrossRefGoogle Scholar
  36. Li J, Wu X, Ding G, Feng Y, Jiang X, Guo L, Che Y (2012a) α-Pyrones and Pyranes from the Plant Pathogenic Fungus Pestalotiopsis scirpina. Eur J Org Chem 12:2445–2452CrossRefGoogle Scholar
  37. Li S, Wei M, Chen G, Lin Y (2012b) Two new dihydroisocoumarins from the endophytic fungus Aspergillus Sp. Chem Nat Compd 48(3):371–373CrossRefGoogle Scholar
  38. Li X, Guo Z, Deng Z, Yang J, Zou K (2015a) A new α-pyrone derivative from endophytic fungus Pestalotiopsis microspora. Rec Nat Prod 9(4):503–508Google Scholar
  39. Li J, Xie J, Yang YH, Li XL, Zeng Y, Zhao PJ (2015b) Pestalpolyols A-D, Cytotoxic Polyketides from Pestalotiopsis sp. cr013. Planta Med 81(14):1285–1289PubMedCrossRefGoogle Scholar
  40. Liu L (2011) Bioactive metabolites from the plant endophyte Pestalotiopsis fici. Mycology 2(1):37–45CrossRefGoogle Scholar
  41. Liu S, Liu L (2010) Isoprenylated chromones from the plant endophytic fungus Pestalotiopsis fici. Junwu Xuebao 29(4):582–587Google Scholar
  42. Liu L, Liu S, Jiang L, Chen X, Guo L, Che Y (2008a) Chloropupukeananin, the first chlorinated pupukeanane derivative, and its precursors from Pestalotiopsis fici. Org Lett 10(7):1397–1400PubMedCrossRefGoogle Scholar
  43. Liu L, Tian R, Liu S, Chen X, Guo L, Che Y (2008b) Pestaloficiols A-E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici. Bioorg Med Chem 16(11):6021–6026PubMedCrossRefGoogle Scholar
  44. Liu L, Liu S, Chen X, Guo L, Che Y (2009a) Pestalofones A-E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici. Bioorg Med Chem 17(2):606–613PubMedCrossRefGoogle Scholar
  45. Liu L, Li Y, Liu S, Zheng Z, Chen X, Zhang H, Guo L, Che Y (2009b) Chloropestolide A, an antitumor metabolite with an unprecedented spiroketal skeleton from Pestalotiopsis fici. Org Lett 11(13):2836–2839PubMedCrossRefGoogle Scholar
  46. Liu L, Liu S, Niu S, Guo L, Chen X, Che Y (2009c) Isoprenylated chromone derivatives from the plant endophytic fungus Pestalotiopsis fici. J Nat Prod 72(8):1482–1486PubMedCrossRefGoogle Scholar
  47. Liu L, Niu S, Lu X, Chen X, Zhang H, Guo L, Che Y (2010) Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels-Alder reaction and then mechanistic diversification. Chem Commun 46(3):460–462CrossRefGoogle Scholar
  48. Liu SC, Ye X, Guo LD, Liu L (2011a) Cytotoxic isoprenylated epoxycyclohexanediols from the plant endophyte Pestalotiopsis fici. Zhongguo Tianran Yaowu 9(5):374–379Google Scholar
  49. Liu L, Bruhn T, Guo L, Goetz DCG, Brun R, Stich A, Che Y, Bringmann G (2011b) Chloropupukeanolides C-E: cytotoxic pupukeanane chlorides with a spiroketal skeleton from Pestalotiopsis fici. Chem---Eur J 17(9):2604–2613PubMedCrossRefGoogle Scholar
  50. Liu H, Liu S, Guo L, Zhang Y, Cui L, Ding G (2012) New furanones from the plant endophytic fungus Pestalotiopsis besseyi. Molecules 17:14015–14021PubMedCrossRefGoogle Scholar
  51. Liu L, Li Y, Li L, Cao Y, Guo L, Liu G, Che Y (2013a) Spiroketals of Pestalotiopsis fici provide evidence for a biosynthetic hypothesis involving diversified diels-alder reaction cascades. J Org Chem 78(7):2992–3000PubMedCrossRefGoogle Scholar
  52. Liu S, Guo L, Che Y, Liu L (2013b) Pestaloficiols Q-S from the plant endophytic fungus Pestalotiopsis fici. Fitoterapia 85:114–118PubMedCrossRefGoogle Scholar
  53. Liu S, Liu X, Guo L, Che Y, Liu L (2013c) 2H-Pyran-2-one and 2H-Furan-2-one derivatives from the plant endophytic fungus Pestalotiopsis fici. Chem Biodivers 10(11):2007–2013PubMedCrossRefGoogle Scholar
  54. Liu L, Zhao C, Li L, Guo L, Che Y (2015) Pestalotriols A and B, new spiro[2.5]octane derivatives from the endophytic fungus Pestalotiopsis fici RSC. Advances 5(96):78708–78711Google Scholar
  55. Liu Y, Yang MH, Wang XB, Li TX, Kong LY (2016) Caryophyllene sesquiterpenoids from the endophytic fungus, Pestalotiopsis sp. Fitoterapia 109:119–124PubMedCrossRefGoogle Scholar
  56. Luo DQ, Zhang L, Shi BZ, Song XM (2012) Two new oxysporone derivatives from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua. Molecules 17:8554–8560CrossRefGoogle Scholar
  57. Muthumary J, Sashirekha S (2007) Detection of taxol, an anticancer drug, from selected coelomycetous fungi. Indian J Sci Technol 1(1):1–10Google Scholar
  58. Nagata T, Ando Y, Hirota A (1992) Phytotoxins from tea gray blight fungi, Pestalotiopsis longiesta and Pestalotiopsis theae. Biosci Biotechnol Biochem 56(5):810–811PubMedCrossRefGoogle Scholar
  59. Ogawa T, Ando K, Aotani Y, Shinoda K, Tanaka T, Tsukuda E, Yoshida M, Matsuda Y (1995) RES-1214-1 and -2, novel non-peptidic endothelin type A receptor antagonists produced by Pestalotiopsis sp. J Antibiot 48(12):1401–1406PubMedCrossRefGoogle Scholar
  60. Ortega HE, Shen YY, TenDyke K, Rios N, Cubilla-Rios L (2014) Polyhydroxylated macrolide isolated from the endophytic fungus Pestalotiopsis mangiferae. Tetrahedron Lett 55(16):2642–2645CrossRefGoogle Scholar
  61. Perez Hemphill CF, Daletos G, Liu Z, Lin W, Proksch P (2016) Polyketides from the mangrove-derived fungal endophyte Pestalotiopsis clavispora. Tetrahedron Lett 57(19):2078–2083CrossRefGoogle Scholar
  62. Qi QY, Li EW, Han JJ, Pei YF, Ma K, Bao L, Huang Y, Zhao F, Liu HW (2015) New ambuic acid derivatives from the solid culture of Pestalotiopsis neglecta and their nitric oxide inhibitory activity. Sci Rep 5:9958PubMedPubMedCentralCrossRefGoogle Scholar
  63. Qian YX, Kang JC, Luo YK, Zhao JJ, He J, Geng K (2016) A bilobalide-producing endophytic fungus, Pestalotiopsis uvicola from medicinal plant Ginkgo biloba. Curr Microbiol 73(2):280–286PubMedCrossRefGoogle Scholar
  64. Ranjan N, Andreasen KF, Kumar S, Hyde-Volpe D, Arya DP (2010) Aminoglycoside binding to Oxytricha nova telomeric DNA. Biochemistry 49:9891–9903PubMedPubMedCentralCrossRefGoogle Scholar
  65. Ranjan N, Davis E, Xue L, Arya DP (2013) Dual recognition of the human telomeric G-quadruplex by a neomycin-anthraquinone conjugate. Chem Commun 49:5796–5798CrossRefGoogle Scholar
  66. Rowinsky E (1997) The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents. Annu Rev Med 48:353–374PubMedCrossRefGoogle Scholar
  67. Srinivasan K, Muthumary J (2009) Taxol production from Pestalotiopsis sp. an endophytic fungus isolated from Catharanthus roseus. J Ecobiotechnol 1:28–31Google Scholar
  68. Steyaert RL (1949) Contribution à l’étude monographigue de Pestalotia de Not. et Monochaetia Sacc. (Truncatella gen. nov. et Pestalotiopsis gen. nov.). Bull Jard Bot l’Etat Brux 19:285–354CrossRefGoogle Scholar
  69. Steyaert RL (1953a) New and old species of Pestalotiopsis. Trans Br Mycol Soc 36:81–89CrossRefGoogle Scholar
  70. Steyaert RL (1953b) Pestalotiopsis from the gold coast and Togoland. Trans Br Mycol Soc 36:235–242CrossRefGoogle Scholar
  71. Stierle A, Strobel GA, Stierle D (1993) Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260:214–216PubMedCrossRefGoogle Scholar
  72. Strobel G, Daisy B (2003) Bioprospecting for microbial endophytes and their natural products. Microbiol Mol Biol Rev 67(4):491–502PubMedPubMedCentralCrossRefGoogle Scholar
  73. Strobel GA, Hess WM, Ford E, Sidhu RS, Yang X (1996) Taxol from fungal endophytes and the issue of biodiversity. J Ind Microbiol 17:417–423CrossRefGoogle Scholar
  74. Strobel GA, Hess WM, Li JY, Ford E, Sears J, Sidhu RS, Summerell B (1997) Pestalotiopsis guepinii, a taxol-producing endophyte of the Wollemi pine, Wollemia nobilis. Aust J Bot 45:1073–1082CrossRefGoogle Scholar
  75. Strobel G, Ford E, Worapong J, Harper JK, Arif AM, Grant DM, Fung PCW, Chau RMW (2002) Isopestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities. Phytochemistry 60(2):179–183PubMedCrossRefGoogle Scholar
  76. Subban K, Subramani R, Muthumary J (2013) A novel antibacterial and antifungal phenolic compound from the endophytic fungus Pestalotiopsis mangiferae. Nat Prod Res 27(16):1445–1449PubMedCrossRefGoogle Scholar
  77. Sun JF, Lin X, Zhou XF, Wan J, Zhang T, Yang B, Yang XW, Tu Z, Liu Y (2014) Pestalols A-E, new alkenyl phenol and benzaldehyde derivatives from endophytic fungus Pestalotiopsis sp. AcBC2 isolated from the Chinese mangrove plant Aegiceras corniculatum. J Antibiot 67(6):451–457PubMedCrossRefGoogle Scholar
  78. Uzor PF, Odimegwu DC, Ebrahim W, Osadebe PO, Nwodo NJ, Okoye FBC, Liu Z, Proksch P (2016) Anti-respiratory syncytial virus compounds from two endophytic fungi isolated from nigerian medicinal plants. Drug Res 66(10):527–531CrossRefGoogle Scholar
  79. Vennila R, Muthumary J (2010) Taxol from Pestalotiopsis pauciseta VM1 an endophytic fungus of Tabebuia pentaphylla. Biomed Prev Nutr 1(2):103–108CrossRefGoogle Scholar
  80. Wang J, Wei X, Lu X, Xu F, Wan J, Lin X, Zhou X, Liao S, Yang B, Tu Z et al (2014) Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel (L.) Druce. Tetrahedron 70(51):9695–9701CrossRefGoogle Scholar
  81. Wang X, Zhang X, Liu L, Xiang M, Wang W, Sun X, Che Y, Guo L, Liu G, Guo L et al (2015a) Genomic and transcriptomic analysis of the endophytic fungus Pestalotiopsis fici reveals its lifestyle and high potential for synthesis of natural products. BMC Genom 16:28/1–28/13CrossRefGoogle Scholar
  82. Wang X, Wu F, Liu L, Liu X, Che Y, Keller NP, Guo L, Yin WB (2015b) The bZIP transcription factor PfZipA regulates secondary metabolism and oxidative stress response in the plant endophytic fungus Pestalotiopsis fici. Fungal Genet Biol 81:221–228PubMedCrossRefGoogle Scholar
  83. Wang J, Wei X, Qin X, Chen H, Lin X, Zhang T, Yang X, Liao S, Yang B, Liu J et al (2015c) Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce. Phytochem Lett 12:59–62CrossRefGoogle Scholar
  84. Wang B, Zhang Z, Guo L, Liu L (2016) New cytotoxic meroterpenoids from the plant endophytic fungus Pestalotiopsis fici. Helv Chim Acta 99(2):151–156CrossRefGoogle Scholar
  85. Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT (1971) Plant antitumor agents VI: the isolation and structure of taxol, a novel antilekemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93:2325–2327PubMedCrossRefGoogle Scholar
  86. Watkins D, Ranjan N, Kumar S, Gong C, Arya DP (2013) An assay for human telomeric G-quadruplex DNA binding drugs Bioorg. Med Chem Lett 23:6695–6699CrossRefGoogle Scholar
  87. Wei MY, Li D, Shao CL, Deng DS, Wang CY (2013) (±)-Pestalachloride D, an antibacterial racemate of chlorinated benzophenone derivative from a soft coral-derived fungus Pestalotiopsis sp. Marine Drugs 11:1050–1060PubMedPubMedCentralCrossRefGoogle Scholar
  88. Wu B, Wu X, Sun M, Li M (2013) Two novel tyrosinase inhibitory sesquiterpenes induced by CuCl2 from a marine-derived fungus Pestalotiopsis sp. Z233. Marine Drugs 11(8):2713–2721PubMedPubMedCentralCrossRefGoogle Scholar
  89. Xia X, Liu C, Kim S, Shim SH (2016) Secondary metabolites produced by an endophytic fungus Pestalotiopsis sydowiana and their 20S proteasome inhibitory activities. Molecules 21(7):944CrossRefGoogle Scholar
  90. Xie J, Li J, Yang YH, Chen YH, Zhao PJ (2014) Two new ambuic acid analogs from Pestalotiopsis sp. cr 013. Phytochem Lett 10:291–294CrossRefGoogle Scholar
  91. Xie J, Li J, Yang YH, Li XN, Chen YH, Zhao PJ (2015) Four pestalpolyols from a mycoparasite Pestalotipsis sp. PG52. Arch Pharm Res. doi: 10.1007/s12272-015-0675-7 Google Scholar
  92. Xing Q, Gan LS, Mou XF, Wang W, Wang CY, Wei MY, Shao CL (2016) Isolation, resolution and biological evaluation of pestalachlorides E and F containing both point and axial chirality. RSC Adv 6(27):22653–22658CrossRefGoogle Scholar
  93. Xu J, Kjer J, Sendker J, Wray V, Guan H, Edrada RA, Lin W, Wu J, Proksch P (2009) Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. J Nat Prod 72(4):662–665PubMedCrossRefGoogle Scholar
  94. Xu J, Ebada SS, Proksch P (2010) Pestalotiopsis a highly creative genus: chemistry and bioactivity of secondary metabolites. Fungal Divers 44(1):15–31CrossRefGoogle Scholar
  95. Xu X, Liu L, Zhang F, Wang W, Li J, Guo L, Che Y, Liu G (2014) Identification of the first diphenyl ether gene cluster for pestheic acid biosynthesis in plant endophyte Pestalotiopsis fici. ChemBioChem 15(2):284–292PubMedCrossRefGoogle Scholar
  96. Xu D, Yang XL, Zhang BY (2016a) Antifungal monoterpene derivatives from the plant endophytic fungus Pestalotiopsis foedan. Chem Biodivers 13(10):1422–1425PubMedCrossRefGoogle Scholar
  97. Xu MF, Jia OY, Wang SJ, Zhu Q (2016b) A new bioactive diterpenoid from Pestalotiopsis adusta, an endophytic fungus from Clerodendrum canescens. Nat Prod Res 30:2642–2647CrossRefGoogle Scholar
  98. Xue LA, Ranjan N, Arya DP. (2011) Synthesis and spectroscopic studies of the Aminoglycoside (Neomycin)-Perylene conjugate binding to human telomeric DNA. Biochemistry 50:2838–2849PubMedCrossRefGoogle Scholar
  99. Yang XL, Li ZZ (2013) New spiral γ-lactone enantiomers from the plant endophytic fungus Pestalotiopsis foedan. Molecules 18:2236–2242PubMedCrossRefGoogle Scholar
  100. Yang XL, Zhang S, Hu QB, Luo DQ, Zhang Y (2011a) Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae. J Antibiot 64(11):723–727PubMedCrossRefGoogle Scholar
  101. Yang XL, Zhang S, Song SJ, Zhang Y, Luo DQ, Zhang M (2011b) A new biphenyl from the fermentation broth of plant endophytic fungus Pestalotiopsis zonata isolated from Cyrtotachys lakka. Zhongguo Tianran Yaowu 9(2):101–104Google Scholar
  102. Yang X, Zhang J, Luo D (2012) The taxonomy, biology and chemistry of the fungal Pestalotiopsis genus. Nat Prod Rep 29:622–641PubMedCrossRefGoogle Scholar
  103. Yvon AMC, Wadsworth P, Jordann MA (1999) Taxol suppresses dynamics of individual microtubules in living human tumor cells. Mol Biol Cell 10:947–959PubMedPubMedCentralCrossRefGoogle Scholar
  104. Zhang YL, Ge HM, Li F, Song YC, Tan RX (2008) New phytotoxic metabolites from Pestalotiopsis sp. HC02, a fungus residing in Chondracris rosea gut. Chem Biodivers 5(11):2402–2407PubMedCrossRefGoogle Scholar
  105. Zhang F, Ding G, Li L, Cai X, Si Y, Guo L, Che Y (2012) Isolation, antimicrobial activity, and absolute configuration of the furylidene tetronic acid core of pestalotic acids A-G. Org Biomol Chem 10(27):5307–5314PubMedCrossRefGoogle Scholar
  106. Zhao J, Shan T, Mou Y, Zhou L (2011) Plant-derived bioactive compounds produced by endophytic Fungi. Mini-Rev Med Chem 11:159–168PubMedCrossRefGoogle Scholar
  107. Zhou X, Lin X, Ma W, Fang W, Chen Z, Bin L, Yang B (2014) A new aromatic amine from fungus Pestalotiopsis vaccinii. Phytochem Lett 7:35–37CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  1. 1.TERI–Deakin Nano Biotechnology CentreThe Energy and Resources InstituteNew DelhiIndia
  2. 2.Department of Biotechnology, College of Engineering and TechnologyIILM-Academy of Higher LearningGreater NoidaIndia

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