Recent advances in the discovery of bioactive metabolites from Pestalotiopsis
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Fungal endophytes have marked a significant impact on drug discovery reducing the burden and dependency on plants. The vast diversity of Pestalotiopsis sp. has emerged as promising source of wide range of bioactive natural compounds. Recently a series of numerous novel secondary metabolites have been discovered of which taxol has drawn attention of scientific community towards its medicinal potential. A wide variety of compounds like alkaloids, polyketides, terpenoids, flavonoids, coumarins, xanthones, quinones, semiquinones, peptides, phenols, phenolic acids, and lactones have been identified which have usage as antimicrobial, antifungal, antiviral antoneoplastic, and antioxidant activities. This review aims to highlight recent discoveries of different strains of Pestalotiopsis identified for producing natural bioactive compounds along with insights of their source of origin and potential in biotechnological applications.
KeywordsPestalotiopsis Endophytes Drug discovery Natural products Anticancer agents Taxol
Authors are thankful to Dr. Alok Adholeya, Senior Director, Biotechnology and Bioresouces Division, The Energy and Resources Institute, Darbari Seth Block, IHC Complex, Lodhi Road, New Delhi, India, for help and continuous support.
SKD, VP, and NR reviewed the contents critically. VP and NR drew chemical structures and assisted in the preparation of Table 2. SKD and NR wrote the review.
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