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Distribution of α-Synuclein Aggregation in the Peripheral Tissues

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Abstract

Parkinson’s disease (PD) is a chronic neurodegenerative disease mainly characterized by movement disorders and other non-motor symptoms, including the loss of dopaminergic neurons in the substantia nigra parts. Abnormal α-synuclein aggregation in the brain is closely associated with the loss of dopaminergic neurons. α-synuclein can propagate in the central nervous system (CNS) and periphery under pathological conditions. Many researches have focused on its aggregation and distribution in the CNS and explored its relationship with PD. But in recent years, the distribution of α-synuclein in peripheral tissues have been paid much attention. This review summarized the distribution of α-synuclein in the choroid plexus, blood, saliva, gastrointestine and other tissues, and discussed the potential mechanism of α-synuclein aggregation, providing a basis for the early diagnosis and intervention of PD.

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Data Availability

Enquiries about data availability should be directed to the authors.

Abbreviations

PD:

Parkinson’s disease,

LBs:

Lewy bodies

RBD:

Rapid-eye-movement sleep behavior disorder

CNS:

Central nervous system

CSF:

Cerebrospinal fluid

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Acknowledgements

This work was supported by NHC Key Laboratory of Drug Addiction Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, China(2020DAMOP-008), the National Natural Science Foundation of China (81773925, and 81730096), the Beijing Natural Science Foundation (7212156), and CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-1-I2M-026).

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Authors and Affiliations

  1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

    Yan-yan Li, Tian-tian Zhou, Nai-Hong Chen & Yu-He Yuan

  2. Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China

    Yi Zhang

  3. Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, I Xiannongtan Street, Xicheng District, Beijing, 100050, China

    Nai-Hong Chen & Yu-He Yuan

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  1. Yan-yan Li
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  3. Yi Zhang
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YL, TZ: Investigation, Writing—Original Draft. YZ: Writing—Review & Editing. NHC: Writing—Review & Editing, Supervision. YHY: Writing—Review & Editing, Supervision.

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Correspondence to Nai-Hong Chen or Yu-He Yuan.

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Li, Yy., Zhou, Tt., Zhang, Y. et al. Distribution of α-Synuclein Aggregation in the Peripheral Tissues. Neurochem Res 47, 3627–3634 (2022). https://doi.org/10.1007/s11064-022-03586-0

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  • DOI: https://doi.org/10.1007/s11064-022-03586-0

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