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Volumetric asymmetry of the major association white fibers in healthy young adults

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Abstract

We studied the volumetric interhemispheric asymmetry of the major association tracts, their asymmetry between gender and handedness groups, and the correlation between different asymmetry indices. A dataset of diffusion-weighted images from 40 healthy subjects was used for generalized, q-sampling imaging tractography. The asymmetry between hemispheres, genders, and types of handedness was analyzed. The arcuate fasciculus (AF) and its temporoparietal part (TP) showed significant asymmetry towards the left, while the superior longitudinal fasciculus 2 (SLF 2), SLF 3, and the uncinate fasciculus (UF) showed significant asymmetry towards the right. Females had a larger volume of right inferior front-occipital fasciculus and right TP, while males had larger right SLF 3. The left-handed subjects have a larger right SLF 2 volume than the right-handed. There was a positive correlation between three pairs of association tracts, normalized-volume laterality indices, the AF - UF, the frontal aslant tract - middle longitudinal fasciculus (MdLF), and the MdLF -TP. In summary, in healthy adults, certain association tracts showed a variable degree of significant asymmetries between both hemispheres, especially the AF and SLF3. Also, a few association tracts had asymmetries between both gender and handedness groups.

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Data availability

All data used in this study are from the open-source Human Connectome Project database; thus, no special data is associated with this study.

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Authors and Affiliations

  1. Department of Neurosurgery, Fukushima Medical University, Fukushima City, 960-1295, Japan

    Mudathir Bakhit, Ryo Hiruta & Masazumi Fujii

  2. Department of Neurosurgery, Aichi Medical University, Aichi, 480-1195, Japan

    Kenichiro Iwami

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  1. Mudathir Bakhit
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  2. Ryo Hiruta
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  4. Masazumi Fujii
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Study concept and design: all authors; Data processing and analysis: Mudathir Bakhit; Streamlines selection: Mudathir Bakhit and Masazumi Fujii; Results interpretation: all authors; Drafting of the manuscript: Mudathir Bakhit and Masazumi Fujii; Critical revision of the manuscript and approval of the article final form: all authors.

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Bakhit, M., Hiruta, R., Iwami, K. et al. Volumetric asymmetry of the major association white fibers in healthy young adults. Neurosci Behav Physi 52, 791–805 (2022). https://doi.org/10.1007/s11055-022-01241-3

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