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Mapping temporo-parietal and temporo-occipital cortico-cortical connections of the human middle longitudinal fascicle in subject-specific, probabilistic, and stereotaxic Talairach spaces

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Abstract

Originally, the middle longitudinal fascicle (MdLF) was defined as a long association fiber tract connecting the superior temporal gyrus and temporal pole with the angular gyrus. More recently its description has been expanded to include all long postrolandic cortico-cortical association connections of the superior temporal gyrus and dorsal temporal pole with the parietal and occipital lobes. Despite its location and size, which makes MdLF one of the most prominent cerebral association fiber tracts, its discovery in humans is recent. Given the absence of a gold standard in humans for this fiber tract, its precise and complete connectivity remains to be determined with certainty. In this study using high angular resolution diffusion MRI (HARDI), we delineated for the first time, six major fiber connections of the human MdLF, four of which are temporo-parietal and two temporo-occipital, by examining morphology, topography, cortical connections, biophysical measures, volume and length in seventy brains. Considering the cortical affiliations of the different connections of MdLF we suggested that this fiber tract may be related to language, attention and integrative higher level visual and auditory processing associated functions. Furthermore, given the extensive connectivity provided to superior temporal gyrus and temporal pole with the parietal and occipital lobes, MdLF may be involved in several neurological and psychiatric conditions such as primary progressive aphasia and other aphasic syndromes, some forms of behavioral variant of frontotemporal dementia, atypical forms of Alzheimer’s disease, corticobasal degeneration, schizophrenia as well as attention-deficit/hyperactivity Disorder and neglect disorders.

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Acknowledgments

The authors would like to thank Mr. Yeetzou Kao for excellent editorial assistance.

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Authors and Affiliations

  1. Departments of Psychiatry and Neurology Services, Center for Morphometric Analysis, Center for Neural Systems Investigations, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, Boston, MA, 02129, USA

    Nikos Makris, G. M. Papadimitriou, P. Mouradian, I. Ng, Y. Rathi, B. Dickerson & M. Kubicki

  2. Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02215, USA

    Nikos Makris, A. Zhu, M. E. Shenton, Y. Rathi & M. Kubicki

  3. Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 02215, USA

    Nikos Makris

  4. McLean Hospital, Harvard Medical School (Affiliated School/Hospital), Belmont, MA, 02478, USA

    Nikos Makris

  5. VA Boston Healthcare System, Boston, MA, 02130, USA

    A. Zhu & M. E. Shenton

  6. Department of Bioengineering, Politecnico di Milano, Milan, Italy

    E. Scaccianoce, G. Baselli & F. Baglio

  7. Department of Psychology, Colby College, Waterville, ME, 04901, USA

    E. Yeterian

  8. Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02215, USA

    M. E. Shenton & M. Kubicki

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  1. Nikos Makris
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  2. A. Zhu
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  3. G. M. Papadimitriou
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  5. I. Ng
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  7. G. Baselli
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  8. F. Baglio
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  9. M. E. Shenton
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  10. Y. Rathi
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  13. M. Kubicki
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Corresponding author

Correspondence to Nikos Makris.

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Funding

This study was supported, in part, by grants from: NINDS, R21NS077059 and R21NS079905 (NM and BD); from NIA/NIMH, R01AG042512 (NM); from NIMH, R01 MH102377 (MK and NM); from NIMH, R01MH097979 (YR).

Conflicts of interest

Nikolaos Makris, Anni Zhu, George Papadimitriou, Palig Mouradian, Wingkwai I. Ng, Elisa Scaccianoce, Giuseppe Baselli, Francesca Baglio, Martha Shenton, Yogesh Rathi, Brad Dickerson, Edward H. Yeterian and Marek Kubicki declare that they have no conflict of interest.

Informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.

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Makris, N., Zhu, A., Papadimitriou, G.M. et al. Mapping temporo-parietal and temporo-occipital cortico-cortical connections of the human middle longitudinal fascicle in subject-specific, probabilistic, and stereotaxic Talairach spaces. Brain Imaging and Behavior 11, 1258–1277 (2017). https://doi.org/10.1007/s11682-016-9589-3

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