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An assessment of ocular elasticity using real time ultrasound and ocular response analyzer in active or remission rheumatoid arthritis

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Abstract

Purpose

To investigate the elasticity of ocular structures in patients with rheumatoid arthritis (RA) without ocular involvement.

Methods

The study included 56 RA patients (study group) and 24 healthy volunteers as the control group. The rheumatoid arthritis patients were divided into two subgroups as those in active phase (Group 1, n = 25) or in remission phase (Group 2, n = 31) according to the disease activity index (DAS 28) score. The elastography values of the ratio of orbital fat-sclera (ROF/S) were measured with real-time US elastography, and corneal mechanical values were measured with the Reichert Ocular Response Analyzer in each eye.

Results

The mean ROF/S value was 5.2 ± 1.8 in Group 1, 0.7 ± 0.4 Group 2, and 0.6 ± 0.1 in the control group. There was a significant difference between the Group 1 and control group with regard to ROF/S (p < 0.001), but no significant difference was determined between Group 2 and control group (p > 0.05). The mean ROF/S value was a significant difference between the Group 1 and 2 (p < 0.001). ROF/S was significantly correlated with DAS-28 and C-reactive protein (CRP) (r = 0.816, p < 0.001 and r = 0.259, p = 0.006).

Conclusions

ROF/S was significantly increased in patients in the active phase of RA. Findings revealed that ocular tissue structural changes may occur in the active phase and these could be related to ocular complications as a prognostic factor.

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Authors and Affiliations

  1. Department of Ophthalmology, Yuksek Ihtisas Training and Research Hospital, Mimarsinan Mahallesi Emniyet Caddesi Polis Okulu Karşısı, Bursa, Turkey

    Mehmet Erol Can & Gamze Dereli Can

  2. Department of Radiology, Yildirim Beyazit University Faculty of Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey

    Özlem Unal

  3. Department of Ophthalmology, Yildirim Beyazit University Faculty of Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey

    Meltem Ece Kars & Nurullah Cagil

  4. Department of Rheumatology, Yildirim Beyazit University Faculty of Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey

    Sukran Erten

  5. Department of Ophthalmology, Kayseri Training and Research Hospital, Kayseri, Turkey

    Necati Duru

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  1. Mehmet Erol Can
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  2. Özlem Unal
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  5. Gamze Dereli Can
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  7. Nurullah Cagil
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Correspondence to Mehmet Erol Can.

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Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Can, M.E., Unal, Ö., Kars, M.E. et al. An assessment of ocular elasticity using real time ultrasound and ocular response analyzer in active or remission rheumatoid arthritis. Int Ophthalmol 39, 2187–2194 (2019). https://doi.org/10.1007/s10792-018-1055-3

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  • DOI: https://doi.org/10.1007/s10792-018-1055-3

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