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Optical coherence tomography and shear wave elastography findings in Graves ophthalmopathy

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Abstract

Purpose

The main feature of Graves ophthalmopathy (GO) is revealed by determining the activity and severity of the disease. We aimed to evaluate the use of imaging methods can also provide additional information about the severity of this disease.

Methods

Optical coherence tomography (OCT) and shear wave elastography (SWE) findings were compared in 32 patients with mild GO group and in the healthy control group. Measuring for TSH receptor antibody (TRAb) serum level is used third-generation assay.

Results

In Graves group, optic nerve sheath diameter (ONSD) values were increased in both eyes (p < 0.001, p < 0.001). SWE measurements showed a significant increase both eye optic nerve (ON) and right eye soft tissue elasticity values in GO group (p < 0.001, p < 0.001, p < 0.001, respectively). There was a significant thinning in left temporal retinal nerve fiber layer (RNFL) thickness and left RNFL peripapillary thickness in GO group (p < 0.001, p < 0.025, respectively). There was a correlation between left eye OCT and SWE findings. Also, there was a significant difference between the median left eye ON and soft tissue elasticity results in the TRAb-positive GO group (p = 0.049, p = 0.048, respectively).

Conclusion

SWE measurements showed a significant increase both eyes ONSD, ON and right eye soft tissue elasticity values in GO group. GO group was significant thinning in some left eye regions in OCT measurements. There was a correlation between left eye OCT and SWE findings. In addition to clinical activity score and TRAb, SWE and OCT can be used to monitor in patients with GO.

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Data and materials availability

Authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. The data that support the findings of this study are available from the corresponding author and the principal investigator, Eren Gürkan, upon reasonable request.

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Acknowledgements

We dedicate this work to the memory of our co-author Ayşe İdil Çakmak, who we lost in the Hatay earthquake. In addition, we would like to thank Emre Dirican for helping us to prepare the statistics of our study.

Funding

None.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Medical Faculty of Tayfur Ata Sökmen, University of Hatay Mustafa Kemal, Alahan Mah, 31001, Hatay, Turkey

    Eren Gürkan

  2. Department of Ophthalmopathy, University of Hatay Mustafa Kemal, Antakya, Hatay, Turkey

    Ayşe İdil Çakmak

  3. Department of Radiology, University of Recep Tayyip Erdoğan, Rize, Turkey

    Gülen Burakgazi

  4. Department of Radiology, University of Hatay Mustafa Kemal, Antakya, Hatay, Turkey

    Fatma Öztürk Keleş

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  1. Eren Gürkan
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  4. Fatma Öztürk Keleş
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Contributions

EG, AİÇ, GB helped in concept, analysis and/or interpretation and literature review; EG, AİÇ, GB, FÖK contributed to design, supervision, materials, critical review, data collection and/or processing; EG, AİÇ were involved in writing.

Corresponding author

Correspondence to Eren Gürkan.

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Authors declare no conflict of interests for this article.

Ethical approval

This study was initiated with the approval of the Hatay Mustafa Kemal University/School of Medicine Ethics Committee (01/08/2019–09). The principles of the Declaration of Helsinki were observed. Written informed consent was obtained from all participants.

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Gürkan, E., Çakmak, A.İ., Burakgazi, G. et al. Optical coherence tomography and shear wave elastography findings in Graves ophthalmopathy. Int Ophthalmol 44, 9 (2024). https://doi.org/10.1007/s10792-024-02931-2

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