Abstract
Glycidyl methacrylate (GMA) was grafted to cellulose nanocrystals (CNCs) using hydroquinone resulting in a crosslinkable nanoparticle. 2-Hydroxyethyl methacrylate (HEMA) was used to polymerize this nanoparticle to obtain a polymeric structure with a bridging CNC structure to which cyclodextrin (CD) was attached in order to better capture hydrophobic biomolecules. X-Ray Microscopy and nuclear magnetic resonance methods provided the main characterization data proving the successful modification process. This CD-modified nanocomposite adsorbent was used for the removal of cholesterol and low-density lipoprotein for the first time. Adsorption performance in a continuous system was ~ 99% for both cholesterol and low-density lipoprotein with agreement between experimental data and mathematical models performed. Overall, results indicate that cyclodextrin modified poly(HEMA-GMA-g-CNC) is a promising material for use as an adsorbent for biological and biomedical applications.
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Acknowledgments
We were hugely indebted to TUBITAK for the support with a 2219-International Postdoctoral Research Fellowship Program with a Grant Number: 1059B191601290. We acknowledge Chven Mitchell who assisted/acquired the images of CD-modified poly(HEMA-GMA-g-CNC) for this study on a Zeiss Xradia 510 Versa 3D X-ray Microscope that was supported by the EVPRP Major Multi-User Equipment Program 2017 at Purdue University. We also acknowledge Md Nuriddin who assisted/acquired the FT-IR data and images of CD-modified poly(HEMA-GMA-g-CNC) for this study on a Nicolet Magna-IR Spectrometer 550 series II (USA) and Pro X PHENOM™ (Phenom-World®, Netherlands) Electron Microscope at Purdue University, respectively.
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Köse, K., Mavlan, M., Uzun, L. et al. Cholesterol removal via cyclodextrin-decoration on cellulose nanocrystal (CNC)-grafted poly(HEMA-GMA) nanocomposite adsorbent. Cellulose 28, 471–487 (2021). https://doi.org/10.1007/s10570-020-03534-7
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DOI: https://doi.org/10.1007/s10570-020-03534-7