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Amino-functionalized cellulose: a novel and high-efficiency scavenger for sodium cholate sorption

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Abstract

In this work, a novel and high-efficiency scavenger based on amino-functionalized cellulose was designed for sodium cholate sorption in vitro. To estimate the adsorption performance of the amino-functionalized cellulose for sodium cholate, various factors including sodium cholate concentration, contact time and electrolyte were investigated. The results suggested that amino-functionalization for cellulose regarding to hyperbranched polyethylenimine not only induce positive charge surface of cellulose but also provide abundant and special binding sites for sodium cholate sorption. The amino-functionalized cellulose displayed an excellent performance to sodium cholate sorption with a maximum adsorption capacity of 569.7 mg/g, higher than cholestyramine, a synthetic lipid-lowering drug in clinic. And the adsorption behavior was well fitted into the Langmuir isotherm model and pseudo-second-order kinetic model, suggesting a homogeneous monolayer chemisorption. Furthermore, the amino-functionalized cellulose presented the features of excellent anti-interferences, cytocompatibility and facile preparation process. All these results support amino-functionalized cellulose as a promising prospect for cholesterol elimination.

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Acknowledgments

The work was financially supported by the Public Technology Research Plan of Zhejiang Province (LGF18E030003), National Natural Science Foundation of China (51672251), and the Fundamental Research Funds of Zhejiang Sci-Tech University (2019Q008).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China

    Junyan Shen, Xiaogang Yang, Xiaoqing Sun, Wenli Gong, Yanan Ma, Lin Liu & Juming Yao

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  1. Junyan Shen
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Correspondence to Lin Liu.

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Shen, J., Yang, X., Sun, X. et al. Amino-functionalized cellulose: a novel and high-efficiency scavenger for sodium cholate sorption. Cellulose 27, 4019–4028 (2020). https://doi.org/10.1007/s10570-020-03066-0

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