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Bioinformatics and its role in the study of the evolution and probiotic potential of lactic acid bacteria

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Abstract

Due to their numerous well-established applications in the food industry, there have been many studies regarding the adaptation and evolution of lactic acid bacteria (LAB) in a wide variety of hosts and environments. Progress in sequencing technology and continual decreases in its costs have led to the availability of LAB genome sequence data. Bioinformatics has been central to the extraction of valuable information from these raw genome sequence data. This paper presents the roles of bioinformatics tools and databases in understanding the adaptation and evolution of LAB, as well as the bioinformatics methods used in the initial screening of LAB for probiotic potential. Moreover, the advantages, challenges, and limitations of employing bioinformatics for these purposes are discussed.

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Acknowledgements

This work was supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, and Forestry (IPET) through the High Value-added Food Technology Development Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA) (grant no. 321035052HD040). It was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1A2C1010406). Figure 1 was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license accessed at https://smart.servier.com/category/cellular-biology/nucleic-acids/ and Vecteezy accessed at https://www.vecteezy.com/

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  1. Department of Animal Resources Science, Dankook University, 119 Dandae-ro, Cheonan, 31116, Republic of Korea

    Remilyn M. Mendoza, Sang Hoon Kim, Robie Vasquez, In-Chan Hwang & Dae-Kyung Kang

  2. Department of Food Science and Biotechnology, Gachon University, Seongnam, 13120, Republic of Korea

    Young-Seo Park

  3. Department of Food Science and Biotechnology of Animal Resource, Konkuk University, Seoul, 05029, Republic of Korea

    Hyun-Dong Paik

  4. Division of Food Science and Biotechnology, Korea National University of Transportation, Jeungpyeong, 27909, Republic of Korea

    Gi-Seong Moon

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Mendoza, R.M., Kim, S.H., Vasquez, R. et al. Bioinformatics and its role in the study of the evolution and probiotic potential of lactic acid bacteria. Food Sci Biotechnol 32, 389–412 (2023). https://doi.org/10.1007/s10068-022-01142-8

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