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Non-enzymatic sensing of glucose at neutral pH values using a glassy carbon electrode modified with carbon supported Co@Pt core-shell nanoparticles

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Abstract

Co@Pt core-shell nanoparticles (NPs) were synthetized by a two-step reductive method using carbon (Vulcan XC-72) as a solid support. The NPs were characterized by X-ray diffraction, field emission gun scanning electron microscopy, energy dispersive X-ray spectroscopy, and transmission electron microscopy. Their electrochemical performance was evaluated by cyclic voltammetry, electrochemical impedance spectroscopy and chronoamperometry, and these showed that the Co@Pt NPs display an electrocatalytic activity towards the oxidation of glucose that is much better than that of plain Pt NPs. Under optimized conditions and at pH 7.0, the oxidation current of glucose at a working potential of −50 mV (vs. SCE) is linearly related to its concentration in the 1.0 to 30 mM range, and the detection limit is 0.3 mM (S/N = 3). It therefore covers the clinical range. The sensor also exhibits excellent stability and repeatability.

Co@Pt core-shell nanoparticles (NPs) display an electrocatalytic activity towards the oxidation of glucose that is much better than that of plain Pt NPs. The oxidation current for glucose is linearly related to its concentration in the 1.0 to 30 mM range, and the detection limit is 0.3 mM (S/N =3).

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Acknowledgments

We acknowledge financial support from the National Natural Science Foundation of China through a project entitled “The synthesis of Pt-M/C nanoparticles and construction of non-enzymatic electrochemical biosensor” (Grant No. 21205030), and by the Science and Technology Department of Hubei province through a project entitled “The development of electrochemical biosensor based on non-noble metal nanocomposites”(2014CFB548), and by State Key Laboratory of Advanced Technology for Materials Synthesis and Processing (Wuhan University of Technology, 2015-KF-13), and from the Natural Science Fund for Creative Research Groups of Hubei Province of China through a project entitled “Controllable Synthesis and Application of Nano-/microsized Functional Materials”(2014CFA015).

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Authors and Affiliations

  1. Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials & Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Ministry of Education & College of Chemistry & Chemical Engineering, Hubei University, Wuhan, 430062, People’s Republic of China

    He Mei, Wenqin Wu, Beibei Yu, Yibin Li, Huimin Wu, Shengfu Wang & Qinghua Xia

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  1. He Mei
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  2. Wenqin Wu
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  3. Beibei Yu
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  7. Qinghua Xia
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Correspondence to Huimin Wu.

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Mei, H., Wu, W., Yu, B. et al. Non-enzymatic sensing of glucose at neutral pH values using a glassy carbon electrode modified with carbon supported Co@Pt core-shell nanoparticles. Microchim Acta 182, 1869–1875 (2015). https://doi.org/10.1007/s00604-015-1524-6

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