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Emerging trends in environmental and industrial applications of marine carbonic anhydrase: a review

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Abstract

Biocatalytic conversion of greenhouse gases such as carbon dioxide into commercial products is one of the promising key approaches to solve the problem of climate change. Microbial enzymes, including carbonic anhydrase, NAD-dependent formate dehydrogenase, ribulose bisphosphate carboxylase, and methane monooxygenase, have been exploited to convert atmospheric gases into industrial products. Carbonic anhydrases are Zn2+-dependent metalloenzymes that catalyze the reversible conversion of CO2 into bicarbonate. They are widespread in bacteria, algae, plants, and higher organisms. In higher organisms, they regulate the physiological pH and contribute to CO2 transport in the blood. In plants, algae, and photosynthetic bacteria carbonic anhydrases are involved in photosynthesis. Converting CO2 into bicarbonate by carbonic anhydrases can solidify gaseous CO2, thereby reducing global warming due to the burning of fossil fuels. This review discusses the three-dimensional structures of carbonic anhydrases, their physiological role in marine life, their catalytic mechanism, the types of inhibitors, and their medicine and industry applications.

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Acknowledgements

The authors express their gratitude to the research council of the University of Hormozgan for financial support during this project.

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Authors and Affiliations

  1. Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, P.O. Box 3995, Bandar Abbas, Iran

    Sudabeh Iraninasab, Sana Sharifian & Ahmad Homaei

  2. Department of Biology, Farhangian University, Tehran, Iran

    Mozafar Bagherzadeh Homaee

  3. Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, 173 234, India

    Tanvi Sharma & Ashok Kumar Nadda

  4. Chembiotech Laboratories, Advanced Science and Technology Institute, The Kyrewood Centre, Tenbury Wells, Worcs, WR15 8FF, UK

    John F. Kennedy

  5. School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian, 223003, China

    Muhammad Bilal

  6. Tecnologico de Monterrey, School of Engineering and Sciences, 64849, Monterrey, Mexico

    Hafiz M. N. Iqbal

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  1. Sudabeh Iraninasab
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  2. Sana Sharifian
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Correspondence to Ahmad Homaei.

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Iraninasab, S., Sharifian, S., Homaei, A. et al. Emerging trends in environmental and industrial applications of marine carbonic anhydrase: a review. Bioprocess Biosyst Eng 45, 431–451 (2022). https://doi.org/10.1007/s00449-021-02667-8

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