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Evaluating prostate cancer bone metastasis using accelerated whole-body isotropic 3D T1-weighted Dixon MRI with compressed SENSE: a feasibility study

  • Magnetic Resonance
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Abstract

Objectives

The study aimed to assess the efficiency of whole-body high-resolution compressed sensing-sensitivity encoding isotropic T1-Weighted Dixon (CSI-T1W-Dixon) scans in evaluating bone metastasis.

Methods

Forty-five high-risk prostate cancer patients with bone metastases were enrolled prospectively and underwent whole-body MRI sequences, which included the following: pre- and post-contrast CSI-T1W-Dixon and conventional multi-planar T1-Weighted Dixon (CMP-T1W-Dixon) (coronal, sagittal, and axial scans), short tau inversion recovery (STIR), and DWI. Comparison between the CMP-T1W-Dixon and CSI-T1W-Dixon images was done for the subjective image quality, the quantitative contrast-to-noise ratio (CNR), and signal-to-noise ratio (SNR). Furthermore, the diagnostic performance based on per-lesion and per-patient basis utilizing non-contrast T1-weighted (T1)/T1+ contrasted T1-weighted (T1C)/T1 + T1C + STIR + DWI sequences was compared between the CSI-T1W-Dixon and CMP-T1W-Dixon methods using reference standards (combining biopsy data and 6-month imaging follow-up).

Result

The CSI-T1W-Dixon images produced fewer image artifacts in the axial and coronal planes compared to the CMP-T1W-Dixon images. Also, the CSI-T1W-Dixon images provided better a CNR in fat-only images of all three planes and water-only images of the axial plane (p < 0.05). The CSI-T1W-Dixon showed a higher sensitivity than the CMP-T1W-Dixon techniques in analyzing T1-only images on a per-lesion basis (82.7% vs. 53.8% for sensitivity, p = 0.03). On a per-patient basis, no difference was found in the diagnostic capacity between the CSI-T1W-Dixon and CMP-T1W-Dixon sequences either alone or in combinations (p = 0.57–1).

Conclusion

High-resolution CSI-T1W-Dixon with higher image quality and diagnostic capacity can replace the CMP-T1W-Dixon method in evaluating bone metastasis in clinical practice.

Key Points

• Compressed sensing isotropic acquisition for 3D T1-weighted Dixon images can improve the image quality with fewer artifacts compared to the anisotropic multiplanar acquisition.

• Compressed sensing isotropic acquisition can save 67% of scanning time compared to anisotropic multiplanar acquisition.

• Compressed sensing isotropic 3D T1-weighted Dixon images can offer better diagnostic performance with higher sensitivity compared to anisotropic multiplanar images.

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Abbreviations

AUC:

Area under the operating characteristic curve

CMP:

Conventional multiplanar

CMP-T1W-Dixon:

Conventional multi-planar T1-Weighted Dixon

CNR:

Contrast-to-noise ratio

Compressed SENSE:

Compressed sensing-sensitivity encoding

CSI:

Compressed SENSE isotropic

CSI-T1W-Dixon:

Compressed SENSE isotropic T1-Weighted Dixon

CT:

Computed tomography

DWI:

Diffusion-weighted imaging

F:

Fat-only

IP:

In-phase

MRI:

Magnetic resonance imaging

OP:

Out-of-phase

PET:

Positron emission tomography

PI:

Parallel imaging

ROC:

Receiver operating characteristic

ROI:

Region of interest

SD:

Standard deviation

SI:

Signal intensity

SNR:

Signal-to-noise ratio

STIR:

Short tau inversion recovery

T1:

Noncontrast T1-weighted

T1C:

Contrast T1-weighted

T1W:

T1-Weighted

W:

Water-only

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Acknowledgements

The authors thank Yong Zhang for his assistance in image analysis.

Funding

The authors state that this work has not received any funding.

Author information

Author notes

  1. Zhenhong Liao and Gaoyuan Liu contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, Deyang People’s Hospital, 173 Taishan North Road, Jingyang District, Deyang City, Sichuan Province, China

    Zhenhong Liao, Gaoyuan Liu, Bing Ming, Chun Ma, Xigang Fan, Wei Peng & Chen Liu

  2. Clinical Science, Philips Healthcare, Chengdu, China

    Xiaoyong Zhang

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  1. Zhenhong Liao
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Corresponding author

Correspondence to Bing Ming.

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Guarantor

The scientific guarantor of this publication is Zhenhong Liao.

Conflict of interest

One of the authors of this manuscript (Xiaoyong Zhang) was an employee of Philips Medical Systems International. The remaining authors declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors (Zhenhong Liao) has significant statistical expertise.

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Study subjects or cohorts overlap

Whole-body compressed sensing isotropic T1-weighted Dixon has not been previously reported.

Methodology

• prospective

• diagnostic study

• performed at one institution

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Liao, Z., Liu, G., Ming, B. et al. Evaluating prostate cancer bone metastasis using accelerated whole-body isotropic 3D T1-weighted Dixon MRI with compressed SENSE: a feasibility study. Eur Radiol 33, 1719–1728 (2023). https://doi.org/10.1007/s00330-022-09181-9

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  • DOI: https://doi.org/10.1007/s00330-022-09181-9

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