Abstract
Introduction
Accurate grading of cerebral glioma using conventional structural imaging techniques remains challenging due to the relatively poor sensitivity and specificity of these methods. The purpose of this study was to evaluate the relative sensitivity and specificity of structural magnetic resonance imaging and MR measurements of perfusion, diffusion, and whole-brain spectroscopic parameters for glioma grading.
Methods
Fifty-six patients with radiologically suspected untreated glioma were studied with T1- and T2-weighted MR imaging, dynamic contrast-enhanced MR imaging, diffusion tensor imaging, and volumetric whole-brain MR spectroscopic imaging. Receiver-operating characteristic analysis was performed using the relative cerebral blood volume (rCBV), apparent diffusion coefficient, fractional anisotropy, and multiple spectroscopic parameters to determine optimum thresholds for tumor grading and to obtain the sensitivity, specificity, and positive and negative predictive values for identifying high-grade gliomas. Logistic regression was performed to analyze all the parameters together.
Results
The rCBV individually classified glioma as low and high grade with a sensitivity and specificity of 100 and 88 %, respectively, based on a threshold value of 3.34. On combining all parameters under consideration, the classification was achieved with 2 % error and sensitivity and specificity of 100 and 96 %, respectively.
Conclusion
Individually, CBV measurement provides the greatest diagnostic performance for predicting glioma grade; however, the most accurate classification can be achieved by combining all of the imaging parameters.
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Acknowledgments
This work was supported in part by Indo-US Science and Technology Forum award no. 20-2009. BR received financial assistance from the University Grant Commission, New Delhi, India. RA received financial assistance from the Indian Council of Medical Research, New Delhi, India. Sequence and software development was carried out under NIH grant R01EB000822.
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We declare that we have no conflict of interest.
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Roy, B., Gupta, R.K., Maudsley, A.A. et al. Utility of multiparametric 3-T MRI for glioma characterization. Neuroradiology 55, 603–613 (2013). https://doi.org/10.1007/s00234-013-1145-x
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DOI: https://doi.org/10.1007/s00234-013-1145-x