Abstract
We evaluated the effect of moderate dietary changes on the prostaglandin system by measuring the urinary excretion of 7α-hydroxy-5,11-dioxo-tetranorprostane-1,16-dioic acid (PGE-M). In a crossover design, twenty-four free-living male subjects in good health (24 to 54 years of age) were fed two diets: (i) Regular (R) diet, 41% energy (en%) from fat, P/S 0.59, M/S 0.96; (ii) Experimental (E) diet, 19 en% from fat, P/S 1.31, M/S 1.48. Diet R contained 13.9 g/day of neutral detergent fiber (NDF) and about 600 mg/day of cholesterol per 3200 kcal; Diet E contained 35.5 g/day NDF and about 280 mg/day cholesterol. Each controlled-diet period lasted ten weeks. The menu cycle was 7 days, and all diets were calculated to provide adequate amounts of essential nutrients. The PGE-M excretion rates were determined in 24-hr urine by stable-isotope dilution gas chromatography-mass spectrometry in the selected ion-monitoring mode. Low-fat Diet E, with an intake of 6.6 en% from polyunsaturates, was associated with an average 14.2% reduction in PGE-M daily output, compared to high-fat Diet R with a 9.3 en% from polyunsaturates (P=0.046). These results support the view that dietary lipid changes can significantly alter thein vivo production of E-series prostaglandins. We cannot conclude, however, if this apparent diet effect was brought about by the change in linoleate intake alone or was the result of complex biochemical interactions among individual fatty acids, both saturated and unsaturated.
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Abbreviations
- AA:
-
arachidonate
- DGLA:
-
dihomo-gamma-linolenate; en%, energy %
- EPA:
-
eicosapentaenoate;
- E:
-
experimental
- LA:
-
linoleate
- NDF:
-
neutral detergent fiber
- PGE-M:
-
7α-hydroxy-5,11-dioxo-tetranorprostane-1,16-dioic acid
- PG:
-
prostaglandin
- R:
-
regular
References
Seyberth, H.W., Oelz, O., Kennedy, T., Sweetman, B.J., Danon, A., Frölich, J.C., Heimberg, M., and Oates, J.A. (1975)Clin. Pharmac. Therapeutics 18, 521–529.
Fischer, S., and Weber, P.C. (1983)Biochem. Biophys. Res. Commun. 116, 1091–1099.
Fischer, S., and Weber, P.C. (1984)Nature 307, 165–168.
Fischer, S., and Weber, P.C. (1985)Biomed. Mass. Spectrom. 12, 470–476.
Weber, P.C., Fischer, S., Schacky, C.v., Lorenz, R., and Strasser, T. (1986)Progr. Lipid Res. 25, 273–276.
Galli, C., Agradi, E., Petroni, A., and Tremoli, E. (1981) inAtherosclerosis Reviews (Hegyeli, R.J., ed.) Vol. 8, pp. 87–99, Raven Press, New York.
Mathias, M.M., and Dupont, J. (1985)Lipids 20, 791–801.
Brenner, R.R. (1981)Progr. Lipid Res. 20, 41–47.
Holman, R.T. (1986)Progr. Lipid Res. 25, 29–39.
Abeywardena, M.Y., McLennan, P.L., and Charnock, J.S. (1987)Atherosclerosis 66, 181–189.
Hintze, T.H., and Kaley, G. (1985) inProstaglandins, Leukotrienes, and Lipoxins (Bailey, J.M., ed.) pp. 321–332, Plenum Press, New York.
Marshall, M.W., Judd, J.T., Matusik, Jr., E.J., Church, J., and Canary, J.J. (1986)J. Amer. Coll. Nutr. 5, 263–279.
Recommended Dietary Allowances. Committee on Dietary Allowances, Food and Nutrition Board, Commission on Life Sciences, National Research Council, 9th edn., Washington, DC, National Academy Press, 1980.
Ferretti, A., Flanagan, V.P., and Reeves, V.B. (1987)Analyt. Biochem. 167, 174–180.
Ferretti, A., Flanagan, V.P., and Roman, J.M. (1985)Analyt. Letters 18(B), 1571–1578.
Heymsfield, S.B., Arteaga, C., McManus, C., Smith, J., and Moffitt, S. (1983)Amer. J. Clin. Nutr. 37, 478–494.
Hassam, A.G., Willis, A.L., Denton, J.P., Stevens, P., and Crawford, M.A. (1979)Lipids 14, 78–80.
Willis, A.L., Hassam, A.G., Crawford, M.A., Stevens, P., and Denton, J.P. (1981)Progr. Lipid Res. 20, 161–167.
Huang, Y.S., Mitchell, J., Jenkins, K., Manku, M.S., and Horrobin, D.F. (1984)Prostaglandins, Leukotrienes and Medicine 15, 223–228.
FitzGerald, G.A., Pedersen, A.K., and Patrono, C. (1983)Circulation 67, 1174–1177.
Hamberg, M., and Samuelsson, B. (1971)J. Biol. Chem. 246, 6713–6721.
Ferretti, A., Judd, J.T., Marshall, M.W., Flanagan, V.P., Roman, J.M., and Matusik, Jr., E.J. (1985)Lipids 20, 268–272.
Zöllner, N., Adam, O., and Wolfram, G. (1979)Res. Exp. Med. (Berlin) 175, 149–153.
Nugteren, D.H., van Evert, W.C., Soeting, W.J., and Spuy, J.H. (1980) inAdvances in Prostaglandin and Thromboxane Research (Samuelsson, B., Ramwell, P.W. and Paoletti, R., eds.) Vol. 8, pp. 1793–1796, Raven Press, New York.
Adam, O., Dill-Wiessner, M., Wolfram, G., and Zöllner, N. (1980)Res. Exp. Med. (Berlin) 177, 227–235.
Adam, O., Wolfram, G., and Zöllner, N. (1982)Ann. Nutr. Metabol. 26, 315–323.
Adam, O., and Wolfram, G. (1984)Amer. J. Clin. Nutr. 40, 763–770.
Nugteren, D.H. (1975)J. Biol. Chem. 250, 2808–2812.
Ferretti, A., Flanagan, V.P., and Roman, J.M. (1983)Analyt. Biochem. 128, 351–358.
Holman, R.T. (1986)J. Amer. Coll. Nutr. 5, 183–211.
Cook, H.W., and Spence, M.W. (1987)Lipids 22, 613–619
Holman, R.T. (1964)Fed. Proc. 23, 1062–1067.
Vergroesen, A.J. (1977)Nutr. Rev. 35, 1–5.
Iacono, J.M., Judd, J.T., Marshall, M.W., Canary, J.J., Dougherty, R.M., Mackin, J.F., and Weinland, B.T. (1981)Progr. Lipid Res. 20, 349–364.
Miettinen, T.A. (1987)Am. J. Clin. Nutr. 45, 1237–1242.
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Ferretti, A., Judd, J.T., Taylor, P.R. et al. Modulating influence of dietary lipid intake on the prostaglandin system in adult men. Lipids 24, 419–422 (1989). https://doi.org/10.1007/BF02535149
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DOI: https://doi.org/10.1007/BF02535149