Abstract
Rabbits were maintained on an EFA-deficient diet. After eight weeks on this diet, lipid analysis showed no major alterations in the levels of brain dihomo-gamma-linolenic and arachidonic acids when compared with animals maintained on the standard laboratory diet. However, there were substantial reductions in the brain prostaglandin contents. It is suggested that the dihomo-gamma-linolenic acid and arachidonic acid utilized for prostaglandin production may be more directly related to the dietary essential fatty acid input rather than to the size of the precursor pool in the principal phospholipids.
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Hassam, A.G., Willis, A.L., Denton, J.P. et al. The effect of essential fatty acid-deficient diet on the levels of prostaglandins and their fatty acid precursors in the rabbit brain. Lipids 14, 78–80 (1979). https://doi.org/10.1007/BF02533572
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DOI: https://doi.org/10.1007/BF02533572