Abstract
A pilot study was undertaken to determine if moderate changes in linoleate (18∶2ω6) intake would modulate the prostaglandin E turnover concurrently with, or independently of, changes in the plasma prostaglandin (PG) precursor levels. Four adult male volunteers in good health were fed two controlled diets containing 35% of energy from fat, with either 10 (diet L) or 30 g (diet H) linoleate/day, 30 to 50 g saturated fatty acids/day, and the balance mainly monounsaturated fatty acids. All four subjects were consuming sufficient amounts of polyunsaturates before the study. Protein (13–14%) and carbohydrate (51–53%) contribution to total caloric intake was kept constant. The menu cycle was 7 days, and all diets were calculated to provide adequate amounts of nutrients known to be required by man when data were available. Plasma fatty acids were determined by gas-liquid chromatography, and the turnover of E prostaglandins was assessed by measuring the urinary output of the major metabolite of PGE1+PGE2 (PGE-M). Whereas we found a clear correlation between 18∶2ω6 intake and 18∶2ω6 concentrations in the neutral lipid (P=0.007) and phosphoglyceride (P=0.012) fractions of plasma, arachidonate (20∶4ω6) concentrations in those same plasma fractions did not respond significantly to changes in linoleate intake. Moreover, we could not detect an influence of moderate changes in dietary levels of 18∶2ω6 on the systemic production of PGE as measured by the daily urinary output of PGE-M.
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Garattini, S., Di Mimmo, G., and de Gaetano, G. (1980) in Hemostasis, Prostaglandins, and Renal Disease (Remuzzi, G., Mecca, G., and de Gaetano, G., eds.) pp. 217–233, Raven Press, New York.
Vergroesen, A.J., ten Hoor, F., and Hornstra, G. (1981) in Nutritional Factors: Modulating Effects on Metabolic Processes (Beers, R.F. Jr., and Bassett, E.G., eds.) pp. 539–549, Raven Press, New York.
McGiff, J.C., and Quilley, J. (1981) in Atherosclerosis Reviews: Prostaglandins and Cardiovascular Disease (Hegyeli, R.J., ed.) Vol. 8, pp. 101–107, Raven Press, New York.
Vergroesen, A.J. (1977) Nutr. Rev. 35, 1–5.
Iacono, J.M., Judd, J.T., Marshall, M.W., Canary, J.J., Dougherty, R.M., Mackin, J.F., and Weinland, B.T. (1981) Progr. Lipid Res. 20, 349–364.
Danon, A., Heimberg, M., and Oates, J.A. (1975) Biochim. Biophys. Acta 388, 318–330.
Seyberth, H.W., Oelz, O., Kennedy, T., Sweetman, B.J., Danon, A., Frölich, J.C., Heimberg, H., and Oates, J.A. (1975) Clin. Pharmacol. Therapeutics 18, 521–529.
Oelz, O., Seyberth, H.W., Knapp, H.R. Jr., Sweetman, B.J., and Oates, J.A. (1976) Biochim. Biophys. Acta 431, 268–277.
Nugteren, D.H., van Evert, W.C., Soeting, W.J., and Spuy, J.H. (1980) in Advances in Prostaglandin and Thromboxane Research (Samuelsson, B., Ramwell, P.W., and Paoletti, R., eds.) Vol. 8, pp. 1793–1796, Raven Press, New York.
Zöllner, N., Adam, O., and Wolfram, G. (1979) Res. Exp. Med. (Berlin) 175, 149–153.
Adam, O., Dill-Wiessner, M., Wolfram, G., and Zöllner, N. (1980) Res. Exp. Med. (Berlin) 177, 227–235.
Adam, O., Wolfram, G., and Zöllner, N. (1982) Ann. Nutr. Metabol. 26, 315–323.
Nugteren, D.H. (1975) J. Biol. Chem. 250, 2808–2812.
Crawford, M.A., Denton, J.P., Hassam, A.G., Lynn, J., Marples, P., Stevens, P., and Willis, A.L. (1978) Br. J. Pharmacol. 63:363P-364P.
Hassam, A.G., Willis, A.L., Denton, J.P., Stevens, P., and Crawford, M.A. (1979) Lipids 14, 78–80.
Willis, A.L., Hassam, A.G., Crawford, M.A., Stevens, P., and Denton, J.P. (1981) Progr. Lipid Res. 20, 161–167.
Huang, Y.S., Mitchell, J., Jenkins, K., Manku, M.S., and Horrobin, D.F. (1984) Prostaglandins Leukotrienes & Medicine 15, 223–228.
USDA Human Nutrition Information Service, Nutrition Monitoring Division, Nutrient Data Research Branch, Hyattsville, MD. 1982 USDA Nutrient Data Base for Standard Reference, Release 2; Composition and Foods: Breakfast Cereals, Raw, Processed, Prepared. Agriculture Handbook No. 8-8, revised July 1982; Composition of Foods: Fruit and Fruit Juices, Raw, Processed, Prepared. Agriculture Handbook No. 8-9, revised July 1982.
Matusik, E.J. Jr., Reeves, V.B., and Flanagan, V.P. (1984) Analyt. Chim. Acta 166, 179–188.
Folch, J., Lees, M., and Sloane-Stanley, G.H. (1957) J. Biol. Chem. 226, 497–509.
Ferretti, A., Flanagan, V.P., and Roman, J.M. (1983) Analyt. Biochem. 128, 351–358.
Hamberg, M., and Samuelsson, B. (1971) J. Biol. Chem. 246, 6713–6721.
Frölich, J.C., Wilson, T.W., Sweetman, B.J., Smigel, M., Nies, A.S., Carr, K., Watson, J.T., and Oates, J.A. (1975) J. Clin. Invest. 55, 763–770.
Ferretti, A., and Flanagan, V.P. (1979) Biomed. Mass Spectrom. 6, 431–434.
Hamberg, M. (1972) Biochem. Biophys. Res. Commun. 49, 720–726.
Seyberth, H.W., Sweetman, B.J., Frölich, J.C., and Oates, J.A. (1976) Prostaglandins 11, 381–397.
Hamberg, M. (1973) Analyt. Biochem. 55, 368–378.
Brash, A.R., Baillie, T.A., Clare, R.A., and Draffan, G.H. (1976) Biochem. Med. 16, 77–94.
Oliw, E., Granström, E., and Änggard, E. (1983) in Prostaglandins and Related Substances (Pace-Asciak, C., and Granström, E., eds.) pp. 1–44, Elsevier, Amsterdam.
Rosenkranz, B., Fischer, C., Boeynaens, J.M., and Frölich, J.C. (1983) Biochim. Biophys. Acta 750, 231–236.
Granström, E., and Samuelsson, B. (1971) J. Biol. Chem. 246, 5254–5263.
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An erratum to this article is available at http://dx.doi.org/10.1007/BF02534444.
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Ferretti, A., Judd, J.T., Marshall, M.W. et al. Moderate changes in linoleate intake do not influence the systemic production of E prostaglandins. Lipids 20, 268–272 (1985). https://doi.org/10.1007/BF02534258
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DOI: https://doi.org/10.1007/BF02534258