Agents and Actions

, Volume 43, Issue 1–2, pp 69–77 | Cite as

Diamine oxidase in relation to diamine and polyamine metabolism

  • Angela Sessa
  • Antonio Perin


Diamine oxidase catalyzes the oxidative deamination of short chain aliphatic diamines, like putrescine, and histamine. The enzyme is rate-limiting in the terminal catabolism of polyamines, which are endogenous polycations important for cell growth and differentiation. This review examines the behavior of diamine oxidase in mammalian tissues in relation to diamine and polyamine metabolism under physiological and pathological conditions. The role of diamine oxidase in the control of putrescine levels in growing tissues and the known mechanisms responsible for the enzyme expression are also described.

Key words

Diamine oxidase Diamine metabolism Polyamine metabolism 


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  1. [1]
    E. A. Zeller,Diamine oxidases. InThe Enzymes, Vol. 8. (Ed. P. D. Boyer, H. Lardy and K. Myrbäck) 2nd Edition, pp. 313–335, Academic Press, New York 1963.Google Scholar
  2. [2]
    F. Buffoni,Histaminase and related amine oxidases. Pharmacol. Rev.18, 1163–1199 (1966).PubMedGoogle Scholar
  3. [3]
    U. Bachrach,Copper amine oxidases and amines as regulators of cellular processes. InStructure and Functions of Amine Oxidases. (Ed. B. Mondovi) pp. 5–20, CRC Press, Boca Raton 1985.Google Scholar
  4. [4]
    R. Kapeller-Adler,Amine Oxidases and Methods for Their Study. Wiley-Interscience, New York 1970.Google Scholar
  5. [5]
    C. Maśliński,Histamine and its metabolism in mammals. Agents and Actions5, 89–107, 183–225 (1975).PubMedGoogle Scholar
  6. [6]
    C. Maśliński and W. A. Fogel,Catabolism of histamine. InHistamine and Histamine Antagonists. (Ed. B. Uvnäs) Handbook Exp. Pharmacol. Vol. 97, 165–189, Springer, Berlin, Heidelberg 1991.Google Scholar
  7. [7]
    A. E. Pegg,Recent advances in the biochemistry of polyamines in eukaryotes. Biochem. J.234, 249–262 (1986).PubMedGoogle Scholar
  8. [8]
    O. Heby and L. Persson,Molecular genetics of polyamine synthesis in eukaryotic cells. Trends Biochem. Sci.15, 153–158 (1990).CrossRefPubMedGoogle Scholar
  9. [9]
    J. Jänne, L. Alhonen and P. Leinonen,Polyamines: From molecular biology to clinical applications, Ann. Med.23, 241–259 (1991).PubMedGoogle Scholar
  10. [10]
    T. L. Sourkes and K. Missala,Histamine metabolism. Putrescine metabolism and the study of diamine oxidase activity in vivo. Agents and Actions11, 20–27 (1981).PubMedGoogle Scholar
  11. [11]
    N. Seiler and B. Eichentopf,4-Aminobutyrate in mammalian putrescine catabolism. Biochem. J.152, 201–210 (1975).PubMedGoogle Scholar
  12. [12]
    T. Okuyama and Y. Kobayashi,Determination of diamine oxidase activity by liquid scintillation counting. Arch. Biochem. Biophys.95, 242–250 (1961).CrossRefPubMedGoogle Scholar
  13. [13]
    K. Missala and T. L. Sourkes,Putrescine catabolism in rats given heparin or aminoguanidine. Eur. J. Pharmacol.64, 307–311 (1980).CrossRefPubMedGoogle Scholar
  14. [14]
    J. Kusche, H. Richter, J. Schmidt, R. Hesterberg, A. Friedrich and W. Lorenz,Diamine oxidase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia. Agents and Actions5, 431–439 (1975).PubMedGoogle Scholar
  15. [15]
    J. Kusche, J. Schmidt, A. Schmidt and W. Lorenz,Diamine oxidases in the small intestine of rabbits, dogs and pigs: Separation from soluble monoamine oxidases and substrate specificity of the enzyme. Agents and Actions5, 440–441 (1975).CrossRefPubMedGoogle Scholar
  16. [16]
    T. Biegański, J. Kusche, W. Lorenz, R. Hesterberg, C.-D. Stahlknecht and K.-D. Feussner,Distribution and properties of human intestinal diamine oxidase and its relevance for histamine catabolism. Biochim. Biophys. Acta756, 196–203 (1983).PubMedGoogle Scholar
  17. [17]
    F. Sánchez-Jiménez, J. M. Matés, J. L. Urdiales, M. A. Medina, E. Viguera, M. Garcia-Caballero and I. N. De Castro,Does histamine behave as a growth-related polyamine? InHistamine in normal and cancer cell proliferation. (Eds. M. Garcia-Caballero, L. J. Brandes and S. Hosoda) pp. 43–70, Pergamon Press, Oxford 1993.Google Scholar
  18. [18]
    R. Hesterberg, J. Sattler, W. Lorenz, C.-D. Stahlknecht, H. Barth and M. Crombach,1. Distribution and metabolism of histamine. Histamine content, diamine oxidase activity and histamine methyltransferase activity in human tissues: Fact or fiction? Agents and Actions14, 325–334 (1984).CrossRefPubMedGoogle Scholar
  19. [19]
    R. E. Shaff and M. A. Beaven,Turnover and synthesis of diamine oxidase (DAO) in rat tissues. Studies with heparin and cycloheximide. Biochem. Pharmacol.25, 1057–1062 (1976).CrossRefPubMedGoogle Scholar
  20. [20]
    K. S. Kim, B. Backus, N. Harris and P. Rourke,Distribution of diamine oxidase and imidazole N-methyltransferase along the gastrointestinal tract. Comp. Biochem. Physiol.31, 137–145 (1969).CrossRefPubMedGoogle Scholar
  21. [21]
    J. Kusche, W. Lorenz, C.-D. Stahlknecht,Diamine oxidase activity in gastric and duodenal mucosa of man and other mammals with special reference to the pyloric junction. Agents and Actions8, 366–371 (1978).CrossRefPubMedGoogle Scholar
  22. [22]
    T. Biegański,Biochemical, physiological and pathophysiological aspects of intestinal diamine oxidase. Acta Physiol. Pol.34, 139–153 (1983).PubMedGoogle Scholar
  23. [23]
    L. D'Agostino, G. D'Argenio, C. Ciacci, B. Daniele, V. Macchia and G. Mazzacca,Diamine oxidase in rat small bowel: Distribution in different segments and cellular location. Enzyme31, 217–220 (1984).PubMedGoogle Scholar
  24. [24]
    J. Kusche, J. R. Izbicki, R. Mennigen, A. Curt and J. V. Parkin,The effect of experimental carcinogenesis on intestinal diamine oxidase, a polyamine deaminating enzyme. Cancer Detect. Prev.9, 17–29 (1986).PubMedGoogle Scholar
  25. [25]
    W. A. Fogel,Mucosal mono- and polyamine oxidase activities in digestive tract are distributed complementary to diamine oxidase. J. Neural Transm. (Suppl.)32, 345–349 (1990).Google Scholar
  26. [26]
    S. B. Baylin, S. A. Stevens and K. M. M. Shakir,Association of diamine oxidase and ornithine decarboxylase with maturing cells in rapidly proliferating epithelium. Biochim. Biophys. Acta541, 415–419 (1978).PubMedGoogle Scholar
  27. [27]
    K. M. M. Shakir, S. Margolis and S. B. Baylin,Localization of histaminase (diamine oxidase) in rat small intestinal mucosa: Site of release by heparin. Biochem. Pharmacol.26, 2343–2347 (1977).CrossRefPubMedGoogle Scholar
  28. [28]
    A. Robertson-White, S. B. Baylin, T. Olivecrona and M. A. Beaven,Binding of diamine oxidase activity to rat and guine pig microvascular endothelial cells. J. Clin. Invest.76, 93–100 (1986).Google Scholar
  29. [29]
    L. D'Agostino, S. Pignata, B. Daniele, R. Ventriglia, G. Ferrari, C. Ferraro, S. Spagnuolo, P. E. Lucchelli and G. Mazzacca,Release of diamine oxidase into plasma by glycosaminoglycans in rats. Biochim. Biophys. Acta993, 228–232 (1989).PubMedGoogle Scholar
  30. [30]
    A. Wollin, H. Navert and G. Bounous,Effect of intestinal ischemia on diamine oxidase activity in rat intestinal tissue and blood. Gastroenterology80, 349–355 (1981).PubMedGoogle Scholar
  31. [31]
    G. D. Luk, W. P. Vaughan, P. J. Burke and S. B. Baylin,Diamine oxidase as a plasma marker of rat intestinal mucosal injury and regeneration after administration of 1-β-D-arabinofuranosylcytosine. Cancer Res.41, 2334–2337 (1981).PubMedGoogle Scholar
  32. [32]
    D. V. Maudsley, J. Leif and Y. Kobayashi,Ornithine decarboxylase in rat small intestine: Stimulation with food or insulin. Am. J. Physiol.231, 1557–1561 (1976).PubMedGoogle Scholar
  33. [33]
    G. D. Luk, L. J. Marton and S. B. Baylin,Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats. Science210, 195–198 (1980).PubMedGoogle Scholar
  34. [34]
    G. D. Luk and S. B. Baylin,Polyamines and intestinal growth. Increased polyamine biosynthesis after jejunectomy. Am. J. Physiol.245, G656-G660 (1983).PubMedGoogle Scholar
  35. [35]
    P. Moore and M. E. Swenseid,Dietary regulation of the activities of ornithine decarboxylase and S-adenosylmethionine decarboxylase in rats. J. Nutr.113, 1927–1935 (1983).PubMedGoogle Scholar
  36. [36]
    G. D. Luk and S. B. Baylin,Inhibition of intestinal epithelial DNA synthesis and adaptive hyperplasia after jejunectomy in the rat by suppression of polyamine biosynthesis. J. Clin. Invest.74, 698–704 (1984).PubMedGoogle Scholar
  37. [37]
    E. R. Seidel, M. K. Haddox and L. R. Johnson,Polyamines in response to intestinal obstruction. Am. J. Physiol.246, G649-G653 (1984).PubMedGoogle Scholar
  38. [38]
    G. D. Luk and P. Yang,Distribution of polyamines and their biosynthetic enzymes in intestinal adaptation. Am. J. Physiol.254, G194-G200 (1988).PubMedGoogle Scholar
  39. [39]
    B. Daniele and A. Quaroni,Polarized secretion of diamine oxidase by intestinal epithelial cells and its stimulation by heparin. Gastroenterology99, 1675–1687 (1990).PubMedGoogle Scholar
  40. [40]
    T. Rokkas, S. Vaja, P. Taylor, G. M. Murphy and R. H. Dowling,Effect of intestinal diamine oxidase (DAO) depletion by heparin on mucosal polyamine metabolism. Digestion46, 378–382 (1990).PubMedGoogle Scholar
  41. [41]
    M. Pinto, S. Robine-Leon, M. D. Appay, M. Kedinger, N. Triadou, E. Dussaulx, B. Lacroix, P. Simon-Assmann, K. Haffen, J. Fongh and A. Zweibaum,Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol. Cell47, 323–330 (1983).Google Scholar
  42. [42]
    L. D'Agostino, B. Daniele, S. Pignata, R. Gentile, P. Tagliaferri, A. Contegiacomo, G. Silvestro, C. Polistina, A. R. Bianco and G. Mazzacca,Ornithine decarboxylase and diamine oxidase in human colon carcinoma cell line CaCo-2 in culture. Gastroenterology97, 888–894 (1989).PubMedGoogle Scholar
  43. [43]
    B. Daniele and A. Quaroni,Effects of epidermal growth factor on diamine oxidase expression and cell growth in Caco-2 cells. Am. J. Physiol.261, G669-G676 (1991).PubMedGoogle Scholar
  44. [44]
    A. Quaroni,Crypt cell antigen expression in human tumor colonic cell lines: analysis with a panel of monoclonal antibodies to CaCo-2 luminal membrane components. J. Natl. Cancer Inst.76, 571–585 (1986).PubMedGoogle Scholar
  45. [45]
    T. Bamba, S. Vaja, G. M. Murphy and R. H. Dowling,Effect of fasting and feeding on polyamines and related enzymes along the villus: crypt axis. Digestion46, 424–429 (1990).PubMedGoogle Scholar
  46. [46]
    S. H. Erdman,Effects of starvation and difluoromethyl-ornithine (DFMO) on diamine oxidase activity in rat ileum. Digestion46, 396–402 (1990).PubMedGoogle Scholar
  47. [47]
    L. D'Agostino, B. Daniele, S. Pignata, M. V. Barone, G. D'Argenio and G. Mazzacca,Modification in ornithine decarboxylase and diamine oxidase in small bowel mucosa of starved and refed rats. Gut28, S1, 135–138 (1987).PubMedGoogle Scholar
  48. [48]
    J. Kusche, W. Lorenz, C.-D. Stahlknecht, H. Richter, R. Hesterberg, A. Schmal, E. Hinterlang, D. Weber and C. Ohmann,Intestinal diamine oxidase and histamine release in rabbit mesenteric ischemia. Gastroenterology80, 980–987 (1981).PubMedGoogle Scholar
  49. [49]
    L. E. Bragg, J. S. Thompson and W. W. West,Intestinal diamine oxidase levels reflect ischemic injury. J. Surg. Res.50, 228–233 (1991).PubMedGoogle Scholar
  50. [50]
    S. Koshi, M. Inoue, H. Obayashi and Y. Miyauchi,Inhibition of post-ischemic reperfusion injury of the small intestine by diamine oxidase. Biochim. Biophys. Acta1075, 231–236 (1991).PubMedGoogle Scholar
  51. [51]
    S. H. Erdman, J. H. Y. Park, J. S. Thompson, C. J. Grandjean, M. H. Hart and J. A. Vanderhoof,Suppression of diamine oxidase activity enhances post-resection ileal proliferation. Gastroenterology96, 1533–1538 (1989).PubMedGoogle Scholar
  52. [52]
    G. D. Luk, T. M. Bayless and S. B. Baylin,Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity. J. Clin. Invest.66, 66–70 (1980).PubMedGoogle Scholar
  53. [53]
    J. Kusche, C.-D. Stahlknecht, W. Lorenz, G. Reichert and H. Richter,Diamine oxidase activity and histamine release in dogs following acute mesenteric artery occlusion. Agents and Actions7, 81–84 (1977).PubMedGoogle Scholar
  54. [54]
    M. Boros, J. Kaszaki and S. Nagy,Oxygen free radical-induced histamine release during intestinal ischemia and reperfusion. Eur. Surg. Res.21, 297–304 (1989).PubMedGoogle Scholar
  55. [55]
    J. Fujisaki, K. Fujimoto, A. Oohara, T. Sakata, M. Hirano, T. Ohyama, R. Iwakiri and M. Yamaguchi,Roles of histamine and diamine oxidase in mucosa of rat small intestine after ischemia-reperfusion. Dig. Dis. Sci.38, 1195–1200 (1993).CrossRefPubMedGoogle Scholar
  56. [56]
    F. Hahn, W. Schmutzler, G. Seseke, H. Giertz and W. Bernauer,Histaminase-freisetzung durch heparin and protamin beim meerschweinchen. Biochem. Pharmacol.15, 155–160 (1966).CrossRefPubMedGoogle Scholar
  57. [57]
    S. B. Baylin, M. A. Beaven, R. M. Krauss and H. R. Keiser,Response of plasma histaminase activity to small doses of heparin in normal subjects and patients with hyperlipoproteinemia. J. Clin. Invest.52, 1985–1993 (1973).PubMedGoogle Scholar
  58. [58]
    V. Gäng, W. Gaubiz and U. Gunzer,Postheparin-diamine oxidase (histaminase) in anaphylaxis. Klin. Wschr.53, 285–287 (1975).CrossRefGoogle Scholar
  59. [59]
    V. Gäng, G. Gehring and J. Schönborn,Combined decrease of postheparin-diamine oxidase (histaminase) and postheparin-lipoproteinlipase in inflammatory diseases. Klin. Wschr.55, 169–173 (1977).CrossRefPubMedGoogle Scholar
  60. [60]
    G. D. Luk, T. M. Bayless and S. B. Baylin,Plasma postheparin diamine oxidase. Sensitive provocative test for quantitating length of acute intestinal mucosal injury in the rat. J. Clin. Invest.71, 1308–1315 (1983).PubMedGoogle Scholar
  61. [61]
    L. D'Agostino, B. Daniele, S. Pignata, M. V. Barone, C. Ciacci, R. Sollazzo and G. Mazzacca,Postheparin plasma diamine oxidase increases in patients with celiac disease during gluten-free diet. Gut28, S1, 131–134 (1987).Google Scholar
  62. [62]
    L. D'Agostino, C. Ciacci, B. Daniele, M. V. Barone, R. Sollazzo, and G. Mazzacca,Postheparin plasma diamine oxidase in subjects with small bowel mucosa atrophy. Dig. Dis. Sci.32, 313–317 (1987).CrossRefPubMedGoogle Scholar
  63. [63]
    G. R. Corazza, A. Falasca, A. Strocchi, C. A. Rossi and G. Gasbarrini,Decreased plasma postheparin diamine oxidase levels in celiac disease. Dig. Dis. Sci.33, 956–961 (1988).CrossRefPubMedGoogle Scholar
  64. [64]
    G. R. Corazza, L. Ginaldi, A. Falasca, A. Strocchi, C. A. Rossi, D. Quaglino and G. Gasbarrini,Diamine oxidase plasma activities after treatment with heparin and jejunal morphometry in untreated coeliac disease. J. Clin. Pathol.42, 1136–1139 (1989).PubMedGoogle Scholar
  65. [65]
    L. D'Agostino, A. Contegiacomo, S. Pignata, N. Zilembo, B. Daniele, C. Ferraro, G. D'Adamo, G. Petrelli, A. R. Bianco and G. Mazzacca,Plasma postheparin diamine oxidase in patients with small intestinal lymphoma. Cancer67, 511–515 (1991).PubMedGoogle Scholar
  66. [66]
    W. U. Schmidt, J. Sattler, R. Hesterberg, H. D. Röher, Th. Zoedler, H. Sitter and W. Lorenz,Human intestinal diamine oxidase (DAO) activity in Crohn's disease: A new marker for disease assessment? Agents and Actions30, 267–270 (1990).CrossRefPubMedGoogle Scholar
  67. [67]
    L. D'Agostino, S. Pignata, B. Daniele, M. Visconti, C. Ferraro, G. D'Adamo, G. Tritto, G. Ambrogio and G. Mazzacca,Postheparin plasma diamine oxidase values in the follow-up of patients with small bowel Crohn's disease. Gut32, 932–935 (1991).PubMedGoogle Scholar
  68. [68]
    R. Hesterberg, J. Kusche, C.-D. Stahlknecht and K.-D. Feussner,The start of a programme for measuring diamine oxidase activity in biopsy specimens of human rectal mucosa. Agents and Actions11, 33–37 (1981).PubMedGoogle Scholar
  69. [69]
    R. Mennigen, J. Kusche, C. Streffer and B. Krakamp,Diamine oxidase activities in the large bowel mucosa of ulcerative colitis patients. Agents and Actions30, 264–266 (1990).CrossRefPubMedGoogle Scholar
  70. [70]
    M. Raithel, A. M. Hörauf, M. Matek and H. W. Baenkler,Kinetics of histamine released from rectal mucosa. Agents and Actions28, 164–167 (1989).CrossRefPubMedGoogle Scholar
  71. [71]
    R. Mennigen, J. Kusche, B. Krakamp, A. Elbers, B. Amoei, M. Kessebohm and H. Sommer,Large bowel tumors and diamine oxidase (DAO) activity in patients: A new approach for risk group identification. Agents and Actions23, 351–353 (1988).PubMedGoogle Scholar
  72. [72]
    S. B. Baylin and G. D. Luk,Diamine oxidase (histaminase) activity in human disease. InPolyamines in Biology and Medicine. (Eds. D. R. Morris and L. J. Marton) pp. 377–388, Marcel Dekker, New York, Basel 1981.Google Scholar
  73. [73]
    A. Sessa, M. A. Desiderio, M. Baizini and A. Perin,Diamine oxidase activity in regenerating rat liver and in 4-dimethylaminoazobenzene-induced and Yoshida AH 130 hepatomas. Cancer Res.41, 1929–1934 (1981).PubMedGoogle Scholar
  74. [74]
    S. B. Baylin and G. D. Luk,Diamine oxidase activity in human tumors: Clinical and biologic significance. InStructure and Functions of Amine Oxidases. (Ed. B. Mondovi) pp. 187–194, CRC Press, Boca Raton 1985.Google Scholar
  75. [75]
    A. Sessa, M. A. Desiderio and A. Perin,Diamine oxidase activity in a model of multistep hepatocarcinogenesis. Cancer Lett.51, 75–78 (1990).CrossRefPubMedGoogle Scholar
  76. [76]
    A. Sessa, E. Broglia, M. R. Terreni and A. Perin,Diamine oxidase activity in rat brain carcinogenesis and in gliomas. Cancer Lett.71, 183–187 (1993).CrossRefPubMedGoogle Scholar
  77. [77]
    J. Kusche, R. Mennigen, L. Leisten and B. Krakamp,Large bowel tumor promotion by diamine oxidase inhibition: Animal model and clinical aspects. InProgress in Polyamine Research. (Eds. V. Zappia, A. E. Pegg) pp. 745–752. Plenum Press, New York, London 1988.Google Scholar
  78. [78]
    J. Kusche, R. Mennigen and L. Leisten,Early alterations of rat intestinal diamine oxidase activity by azoxymethane, an intestinal carcinogen. Agents and Actions27, 218–220 (1989).PubMedGoogle Scholar
  79. [79]
    J. Kusche, A. Horn and R. Mennigen,Large bowel tumor promotion in rats by diamine oxidase inhibition. InPolyamines in the gastrointestinal tract. (Eds. R. H. Dowling, U. R. Fölsch and Chr. Löser) pp. 347–359. Kluwer, Dordrecht 1992.Google Scholar
  80. [80]
    J. Kusche, T. Bieganski, R. Hesterberg, C.-D. Stahlknecht, K.-D. Feussner, J. Stahlenberg and W. Lorenz,The influence of carcinoma growth on diamine oxidase activity in human gastrointestinal tract. Agents and Actions10, 110–113 (1980).PubMedGoogle Scholar
  81. [81]
    N. Seiler,Polyamine metabolism and elimination by the vertebrate organism. InPolyamines in the Gastrointestinal Tract. (Eds. R. H. Dowling, U. R. Fölsch, Chr. Löser) pp. 65–85, Kluwer, Dordrecht 1992.Google Scholar
  82. [82]
    S. K. Guha and J. Jänne,The synthesis and accumulation of polyamines in reproductive organs of the rat during pregnancy. Biochim. Biophys. Acta437, 244–252 (1976).PubMedGoogle Scholar
  83. [83]
    D. V. Maudsley and Y. Kobayashi,Biosynthesis and metabolism of putrescine in the rat placenta. Biochem. Pharmacol.26, 121–124 (1977).CrossRefPubMedGoogle Scholar
  84. [84]
    A. C. Andersson, S. Henningsson and E. Rosengren,Increased formation of diamines and polyamines in the pregnant rat. J. Physiol.285, 311–324 (1978).PubMedGoogle Scholar
  85. [85]
    A. C. Andersson, S. Henningsson and E. Rosengren,Formation of cadaverine in the pregnant rat. Acta Physiol. Scand.105, 508–512 (1979).PubMedGoogle Scholar
  86. [86]
    M. A. Desiderio, A. Sessa and A. Perin,Polyamines and diamine oxidase activity in maternal, embryonal, and fetal tissues of rat after chronic ethanol consumption. Biochim. Biophys. Res. Commun.142, 843–848 (1987).CrossRefGoogle Scholar
  87. [87]
    A. Sessa, M. A. Desiderio and A. Perin,Ethanol and polyamine metabolism in adult and fetal tissues: Possible implication in fetus damage. InAdvances in Alcohol and Substance Abuse. (Ed. B. Stimmel) pp. 73–85. Haworth Press, New York 1987.Google Scholar
  88. [88]
    W. A. Fogel, C. Chmielecki, M. Gralek and C. Maśliński,Histamine metabolism in diabetic rats. Agents and Actions30, 243–246 (1990).CrossRefGoogle Scholar
  89. [89]
    H. Barth, W. Lorenz and I. Niemeyer,Inhibition and activation of histamine methyltransferase by methylated histamine. Hoppe-Seyler's Z. Physiol. Chem.354, 1021–1026 (1973).PubMedGoogle Scholar
  90. [90]
    J. Sattler, D. Häfner, H.-J. Klotter, W. Lorenz and P. K. Wagner,Food-induced histaminosis as an epidemiological problem: Plasma histamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO). Agents and Actions23, 361–365 (1988).PubMedGoogle Scholar
  91. [91]
    J. Sattler, W. Lorenz, K. Kubo, A. Schmal, S. Sauer and L. Lüben,Food-induced histaminosis under diamine oxidase (DAO) blockade in pigs: Further evidence of the key role of elevated plasma histamine levels as demonstrated by successful prophylaxis with antihistamines. Agents and Actions27, 212–214 (1989).PubMedGoogle Scholar
  92. [92]
    J. Sattler and W. Lorenz,Intestinal diamine oxidases and enteral-induced histaminosis: Studies on three prognostic variables in an epidemiological model. J. Neuronal Transm. (Suppl.)32, 291–314 (1990).Google Scholar
  93. [93]
    J. Sattler, W. Lorenz, R. Lindlar and U. Schäfer,Histamine in duodenal ulcer, stress-induced lesions, and upper gastrointestinal bledding: Causality analysis. InHistamine and Histamine Antagonists. (Ed. B. Uvnäs) Handbook Exp. Pharmacol. Vol.97, pp. 441–472, Springer, Berlin, Heidelberg 1991.Google Scholar
  94. [94]
    J. Sattler, R. Hesterberg, W. Lorenz, M. Ennis, C.-D., Stahlknecht and J. Kusche,Pathophysiological functions of diamine oxidase: An evaluation in animal studies using a probabilistic model with several types of causal relationship. InStructure and Functions of Amine Oxidases. (Ed. B. Mondovi) pp. 167–178, CRC Press, Boca Raton 1985.Google Scholar
  95. [95]
    A. Sessa, M. A. Desiderio and A. Perin,Effect of acute ethanol administration on diamine oxidase activity in the upper gastrointestinal tract of rat. Alcoholism: Clin. Exp. Res.8, 185–190 (1984).Google Scholar
  96. [96]
    A. Perin, G. Scalabrino, A. Sessa and A. Arnaboldi,In vitro inhibition of protein synthesis in rat liver as a consequence of ethanol metabolism. Biochim. Biophys. Acta366, 101–108 (1974).PubMedGoogle Scholar
  97. [97]
    A. Sessa, M. A. Desiderio and A. Perin,Stimulation of hepatic and renal diamine oxidase activity after acute ethanol administration. Biochim. Biophys. Acta801, 285–289 (1984).PubMedGoogle Scholar
  98. [98]
    M. Piacentini, C. Sartori, S. Beninati, A. Barqaqli and M. P. Cerù-Argento,Ornithine decarboxylase, transglutaminase, diamine oxidase and total diamines and polyamines in maternal liver and kidney throughout rat pregnancy. Biochem. J.234, 435–440 (1986).PubMedGoogle Scholar
  99. [99]
    A. Sessa, M. A. Desiderio and A. Perin,Effect of acute ethanol administration on diamine oxidase activity in maternal, embryonal and fetal tissues. Agents and Actions21, 49–53 (1987).CrossRefPubMedGoogle Scholar
  100. [100]
    N. C. R. Räihä, M. Koskinen and P. Pikkarainen,Developmental changes in alcohol-dehydrogenase activity in rat and guinea pig liver. Biochem. J.103, 623–626 (1967).PubMedGoogle Scholar
  101. [101]
    A. Sessa and A. Perin,Diamine oxidase activity and related substrates in rat liver after chronic ethanol feeding. Agents and Actions37, 107–110 (1992).CrossRefGoogle Scholar
  102. [102]
    C. S. Lieber,Mechanism of ethanol induced hepatic injury. Pharmac. Ther.46, 1–41 (1990).CrossRefGoogle Scholar
  103. [103]
    A. Sessa and A. Perin,Chronic ethanol feeding and diamine oxidase activity in rat brain and liver. J. Neural Transm. (Suppl.)32, 319–322 (1990).Google Scholar
  104. [104]
    A. Perin and A. Sessa,Relationship between diamine oxidase activity and ethanol-induced gastric damage. InPolyamines in the Gastrointestinal Tract. (Eds. R. H. Dowling, U. R. Fölsch and Chr. Löser) pp. 269–273, Kluwer, Dordrecht 1992.Google Scholar
  105. [105]
    M. A. Desiderio, A. Sessa and A. Perin,Induction of diamin oxidase activity in rat kidney during compensatory hypertrophy. Biochim. Biophys. Acta714, 243–249 (1982).PubMedGoogle Scholar
  106. [106]
    A. Perin, A. Sessa and M. A. Desiderio,Polyamine levels and diamine oxidase activity in hypertrophic heart of spontaneously hypertensive rats and of rats treated with isoproterenol, Biochim. Biophys. Acta755, 344–351 (1983).PubMedGoogle Scholar
  107. [107]
    A. Sessa, M. A. Desiderio and A. Perin,Diamine oxidase activity induction in regenerating rat liver. Biochim. Biophys. Acta698, 11–14 (1982).PubMedGoogle Scholar
  108. [108]
    M. A. Desiderio, I. Zini, P. Davalli, M. Zoli, A. Corti, K. Fuxe and L. F. Agnati,Polyamines, ornithine decarboxylase, and diamine oxidase in the substantia nigra and striatum of the male rat after hemitransection. J. Neurochem.51, 25–31 (1988).PubMedGoogle Scholar
  109. [109]
    M. A. Desiderio, A. Sessa and A. Perin,Diamine oxidase activity inhibition and putrescine levels in renal hypertrophy. InAdvances in Polyamines in Biomedical Science. (Eds. C. M. Caldarera and U. Bachrach) pp. 141–144, CLUEB, Bologna 1984.Google Scholar
  110. [110]
    P. E. Duffy and L. T. Kremzner,Ornithine decarboxylase activity and polyamines in relation to aging of human fibroblasts. Exp. Cell Res.108, 435–440 (1977).PubMedGoogle Scholar
  111. [111]
    J. E. Kay and V. J. Lindsay,Control of ornithine decarboxylase activity in stimulated human lymphocytes by putrescine and spermidine. Biochem. J.132, 791–796 (1973).PubMedGoogle Scholar
  112. [112]
    W. F. Fong, J. S. Heller and E. S. Canellakis,The appearance of an ornithine decarboxylase inhibitory protein upon the addition of putrescine to cell culture. Biochim. Biophys. Acta428, 456–465 (1976).PubMedGoogle Scholar
  113. [113]
    I. Holm, L. Persson, L. Stjernborg, L. Thorsson and O. Heby,Feedback control of ornithine decarboxylase expression by polyamines. Biochim. J.258, 343–350 (1989).Google Scholar
  114. [114]
    R. H. Dowling,Polyamines in intestinal adaptation and disease. Digestion46 (Suppl. 2) 331–344 (1990).PubMedGoogle Scholar
  115. [115]
    P. S. Sunkara, S. Ramakrishna, K. Nishioka and P. N. Rao,The relationship between levels and rates of synthesis of polyamines during mammalian cell cycle. Life Sci.28, 1497–1506 (1981).CrossRefPubMedGoogle Scholar
  116. [116]
    M. A. Desiderio, A. Sessa and A. Perin,Regulation of diamine oxidase expression by β 2-adrenoceptors in normal and hypertrophic rat kidney. Biochim. Biophys. Acta845, 463–468 (1985).CrossRefPubMedGoogle Scholar
  117. [117]
    M. A. Desiderio, A. Sessa and A. Perin,Involvement of beta 2 adrenoceptors in the regulation of diamine oxidase activity in the heart of spontaneously hypertensive rats. J. Hypertension4, S139-S140 (1986).Google Scholar
  118. [118]
    J. D. Veldhuis, T. S. Harrison and J. M. Hammond, β2-adrenergicstimulation of ornithine decarboxylase activity in porcine granulosa cells in vitro. Biochim. Biophys. Acta627, 123–130 (1980).PubMedGoogle Scholar
  119. [119]
    J. Bartolome, J. Huguenard and T. A. Slotkin,Role of ornithine decarboxylase in cardiac growth and hypertrophy. Science210, 793–794 (1980).PubMedGoogle Scholar
  120. [120]
    W. B. Karp, A. F. Robertson and W. P. Kanto, Jr.,The effect of hydrocortisone, thyroxine, and phenobarbital on diamine oxidase activity in newborn rat intestine. Pediatr. Res.21, 368–370 (1987).PubMedGoogle Scholar
  121. [121]
    A. Sessa, M. A. Desiderio and A. Perin,Estrogenic regulation of diamine oxidase activity in rat uterus. Agents and Actions29, 162–166 (1990).CrossRefPubMedGoogle Scholar
  122. [122]
    W. A. Fogel,Diamine oxidase (DAO) and female sex hormones. Agents and Actions18, 44–45 (1986).PubMedGoogle Scholar
  123. [123]
    E. V. O'Loughlin, M. Chung, M. Hollemberg, J. Hayden, I. Zahavi and D. G. Gall,Effect of epidermal growth factor on ontogeny of the gastrointestinal tract. Am. J. Physiol.249, G674-G678 (1985).PubMedGoogle Scholar
  124. [124]
    I. J. Hidalgo, A. Kato and R. T. Borchardt,Binding of epidermal growth factor by human colon carcinoma cell (Caco-2) monolayers. Biochem. Biophys. Res. Commun.160, 317–324 (1989).CrossRefPubMedGoogle Scholar
  125. [125]
    L. R. Fitzpatrick, P. Wang and L. R. Johnson,Effect of epidermal growth factor on polyamine-synthesizing enzymes in rat enterocytes. Am. J. Physiol.252, G209-G214 (1987).PubMedGoogle Scholar
  126. [126]
    A. Perin, A. Sessa and M. A. Desiderio,Response of tissue diamine oxidase activity to polyamine administration. Biochem. J.234, 119–123 (1986).PubMedGoogle Scholar
  127. [127]
    L. D'Agostino, S. Pignata, B. Daniele, C. Ferraro, G. D'Adamo, G. Tritto and G. Mazzacca,Regulation of diamine oxidase expression by ornithine decarboxylase in isolated rat small bowel enterocytes. Digestion46, 403–409 (1990).PubMedGoogle Scholar
  128. [128]
    A. Perin, A. Sessa and M. A. Desiderio,Diamine oxidase in regenerating and hypertrophic tissues. InStructure and Functions of Amine Oxidases. (Ed. B. Mondovi) pp. 179–186, CRC Press, Boca Raton 1985.Google Scholar

Copyright information

© Birkhäuser Verlag 1994

Authors and Affiliations

  • Angela Sessa
    • 1
  • Antonio Perin
    • 2
  1. 1.Consiglio Nazionale delle Ricerche, Centro di Studio sulla Patologia CellulareUniversità di MilanoMilanoItaly
  2. 2.Istituto di Patologia GeneraleUniversità di MilanoMilanoItaly

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