Abstract
Streptozotocin-induced diabetes in rats has been used to study the effect of insulin deficiency on histamine metabolism. There were significant increases in the amine content in the pancreas and intestine, and a significant drop in intestinal diamine oxidase (DAO) activity. The reduced DAO activity may be of clinical relevance.
Similar content being viewed by others
References
A. Orlidge and T. M. Hollis,Aortic endothelial and smooth muscle histamine metabolism in experimental diabetes. Arteriosclerosis2, 142–150 (1982).
T. M. Hollis, J. A. Kern, N. A. Enea and A. J. Cosgarea,Changes in plasma histamine concentrations in the streptozotocin-diabetic rat. Exp. mol. Pathol.43, 90–96 (1985).
D. C. Gill, C. S. Thompson and P. Dandona,Increased histamine in plasma and tissues in diabetic rats. Diabetes Res.7, 31–34 (1988).
R. A. Markle, T. M. Hollis and A. J. Cosgarea,Renal histamine increases in streptozotocin-diabetic rats. Exp. mol. Pathol.44, 21–28 (1986).
W. A. Fogel, M. Ulatowska, K. Adach and Z. Osińska,A sum of 14 C putrescine metabolites as a measure of DAO activity. Column chromatography assay. Agents and Actions16, 99–101 (1985).
S. H. Snyder and J. Axelrod,Sex differences and hormonal control of histamine methyltransferase activity. Biochim. Biophys. Acta111, 416–421 (1965).
W. A. Fogel,Enzymatic histamine catabolism in vertebrate ontogenesis. A comparative study. Comp. Biochem. Physiol.89C, 355–360 (1988).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fogel, W.A., Chmielecki, C., Grałek, M. et al. Histamine metabolism in diabetic rats. Agents and Actions 30, 243–246 (1990). https://doi.org/10.1007/BF01969050
Issue Date:
DOI: https://doi.org/10.1007/BF01969050