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Diamine oxidase activity and related substrates in rat liver after chronic ethanol feeding

  • Inflammation and Immunomodulation
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Abstract

Chronic ethanol feeding as 12% or 36% of total calories caused a dose-dependent diminution of diamine oxidase activity in rat liver. Hepatic cadaverine and histamine levels were unmodified by ethanol, whereas putrescine increased, partially in relation to the decrease in diamine oxidase activity. Such results may be of interest in view of an aggravation of ethanol-induced hepatic damage when exogenous diamines and polyamines reach the liver in potentially toxic amounts.

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Authors and Affiliations

  1. Consiglio Nazionale delle Ricerche, Centro di Studio sulla Patologia Cellulare, and Istituto Patologia Generale, Università di Milano, Via Mangiagalli 31, 20133, Milan, Italy

    A. Sessa & A. Perin

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  1. A. Sessa
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  2. A. Perin
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Sessa, A., Perin, A. Diamine oxidase activity and related substrates in rat liver after chronic ethanol feeding. Agents and Actions 37, 107–110 (1992). https://doi.org/10.1007/BF01987897

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  • DOI: https://doi.org/10.1007/BF01987897

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