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, Volume 19, Issue 5–6, pp 256–265 | Cite as

T lymphocyte autoimmunity in peripheral nervous system autoimmune disease

  • C. Linington
  • H. Wekerle
  • R. Meyermann
T Cells in Chronic Inflammation


Autoaggressive T cells specific for the PNS myelin P2 protein play a central role in the initiation of EAN in the Lewis rat, although there is as yet no direct experimental evidence that the T cells can themselves mediate demyelination in vivo. However, the striking similarities in the pathogenesis of EAN and the Guillain-Barré syndrome suggest that T cell mediated EAN provides an excellent model to study the immunological mechanisms of inflammation and demyelination that are relevant to human PNS disease.


Nervous System Autoimmune Disease Experimental Evidence Peripheral Nervous System Excellent Model 
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Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • C. Linington
    • 1
  • H. Wekerle
    • 1
  • R. Meyermann
    • 1
  1. 1.Max-Planck-Gesellschaft Klinische Forschungsgruppe für Multiple SkleroseWürzburgFederal Republic of Germany

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