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T lymphocyte autoimmunity in peripheral nervous system autoimmune disease

  • T Cells in Chronic Inflammation
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Conclusion

Autoaggressive T cells specific for the PNS myelin P2 protein play a central role in the initiation of EAN in the Lewis rat, although there is as yet no direct experimental evidence that the T cells can themselves mediate demyelination in vivo. However, the striking similarities in the pathogenesis of EAN and the Guillain-Barré syndrome suggest that T cell mediated EAN provides an excellent model to study the immunological mechanisms of inflammation and demyelination that are relevant to human PNS disease.

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  1. Max-Planck-Gesellschaft Klinische Forschungsgruppe für Multiple Sklerose, Josef-Schneider-Str. 11, D-8700, Würzburg, Federal Republic of Germany

    C. Linington, H. Wekerle & R. Meyermann

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Linington, C., Wekerle, H. & Meyermann, R. T lymphocyte autoimmunity in peripheral nervous system autoimmune disease. Agents and Actions 19, 256–265 (1986). https://doi.org/10.1007/BF01971223

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