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Kidney Regeneration: Lessons from Development

  • Development (Section Editor, Donghun Shin)
  • Published:
Current Pathobiology Reports

Abstract

A number of genes involved in kidney development are reactivated in the adult after acute kidney injury (AKI). This has led to the belief that tissue repair mechanisms recapitulate pathways involved in embryonic development after AKI. We will discuss evidence to support this hypothesis by comparing the mechanisms of development with common pathways known to regulate post-AKI repair, or that we identified as cell-specific candidates based on public datasets from recent AKI translational profiling studies. We will argue that while many of these developmental pathways are reactivated after AKI, this is not associated with general cellular reprogramming to an embryonic state. We will show that reactivation of these developmental genes is often associated with expression in cells that are not normally involved in mediating parallel responses in the embryo, and that depending on the cellular context, these responses can have beneficial or detrimental effects on injury and repair after AKI.

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Acknowledgments

We would like to thank Ray Harris for critically reviewing the manuscript. The laboratory of Mark de Caestecker was supported by the National Institutes of Health Grants 1R01 HL093057 and 1RC4DK090770. The laboratory of Neil Hukriede was supported by the National Institutes of Health Grants 2R01 DK069403, 1RC4 DK090770, and 1P30DK079307, Eunice Kennedy Shriver National Institute of Child Health and Human Development Grant 2R01 HD053287.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Vanderbilt University, S3223, Medical Center North, 1161 21st Avenue South, Nashville, TN, 37232, USA

    Takuto Chiba & Mark P. de Caestecker

  2. Department of Cell and Developmental Biology, Vanderbilt University, Nashville, USA

    Takuto Chiba & Mark P. de Caestecker

  3. Department of Developmental Biology, University of Pittsburgh, Pittsburgh, USA

    Neil Hukriede

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  1. Takuto Chiba
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  2. Neil Hukriede
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  3. Mark P. de Caestecker
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Correspondence to Mark P. de Caestecker.

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This article is part of the Topical Collection on Development.

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Chiba, T., Hukriede, N. & de Caestecker, M.P. Kidney Regeneration: Lessons from Development. Curr Pathobiol Rep 3, 67–79 (2015). https://doi.org/10.1007/s40139-015-0069-z

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