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Taurine Treatment Provides Neuroprotection in a Mouse Model of Manganism

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Abstract

Manganese (Mn) is a trace element involved in many physiological processes. However, excessive Mn exposure leads to neurological complications. Although no precise mechanism(s) has been found for Mn-induced neurotoxicity, oxidative stress and mitochondrial injury seem to play a relevant role in this complication. On the other hand, there is no protective strategy against Mn neurotoxicity so far. Taurine is an amino acid with significant neuroprotective properties. The current study was designed to evaluate the effect of taurine supplementation and its potential mechanism(s) of action in a mouse model of manganism. Animals were treated with Mn (100 mg/kg, s.c) alone and/or in combination with taurine (50, 100, and 500 mg/kg, i.p, for eight consecutive days). Severe locomotor dysfunction along with a significant elevation in brain tissue biomarkers of oxidative stress was evident in Mn-exposed mice. On the other hand, it was revealed that mitochondrial indices of functionality were hampered in Mn-treated animals. Taurine supplementation (50, 100, and 500 mg/kg, i.p) alleviated Mn-induced locomotor deficit. Moreover, this amino acid mitigated oxidative stress biomarkers and preserved brain tissue mitochondrial indices of functionality. These data introduce taurine as a potential neuroprotective agent against Mn neurotoxicity. Antioxidative and mitochondria protecting effects of taurine might play a fundamental role in its neuroprotective properties against Mn toxicity.

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Funding

This work was financially supported by Pharmaceutical Sciences Research Center and Vice Chancellor of Research Office of Shiraz University of Medical Sciences (Grant 15295/13477/14210).

Author information

Author notes

  1. Mohammad Mehdi Ommati and Reza Heidari contributed equally to this work.

Authors and Affiliations

  1. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P. O. Box 158371345, Roknabad, Karafarin St., Shiraz, Fars, Iran

    Mohammad Mehdi Ommati, Reza Heidari, Vahid Ghanbarinejad & Hossein Niknahad

  2. Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

    Vahid Ghanbarinejad & Hossein Niknahad

  3. Iran Food and Drug Administration (IFDA), Ministry of Health, Tehran, Iran

    Narges Abdoli

Authors
  1. Mohammad Mehdi Ommati
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  2. Reza Heidari
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  3. Vahid Ghanbarinejad
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  4. Narges Abdoli
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  5. Hossein Niknahad
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Corresponding authors

Correspondence to Reza Heidari or Hossein Niknahad.

Ethics declarations

All the experiments were performed in conformity with the guidelines for care and use of experimental animals which were approved by the ethics committee of Shiraz University of Medical Sciences, Shiraz, Iran (#15295/13477/14210).

Conflict of Interest

The authors declare that they have no conflict of interest.

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Ommati, M.M., Heidari, R., Ghanbarinejad, V. et al. Taurine Treatment Provides Neuroprotection in a Mouse Model of Manganism. Biol Trace Elem Res 190, 384–395 (2019). https://doi.org/10.1007/s12011-018-1552-2

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  • DOI: https://doi.org/10.1007/s12011-018-1552-2

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