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Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review

  • Pharmacologic Treatment of Type 2 Diabetes (HE Lebovitz and G Bahtiyar, Section Editors)
  • Published:
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Abstract

Purpose of Review

This systematic review describes evidence concerning medicinal plants that, in addition to exerting hypoglycemic effects, decrease accompanying complications such as nephropathy, neuropathy, retinopathy, hypertension, and/or hyperlipidemia among individuals with diabetes mellitus (DM).

Recent Findings

Studies on the antidiabetic mechanisms of medicinal plants have shown that most of them produce hypoglycemic activity by stimulating insulin secretion, augmenting peroxisome proliferator-activated receptors (PPARs), inhibiting α-amylase or α-glucosidase, glucagon-like peptide-1 (GLP-1) secretion, advanced glycation end product (AGE) formation, free radical scavenging plus antioxidant activity (against reactive oxygen or nitrogen species (ROS/RNS)), up-regulating or elevating translocation of glucose transporter type 4 (GLUT-4), and preventing development of insulin resistance.

Summary

Not only are medicinal plants effective in DM, but many of them also possess a variety of effects on other disease states, including the complications of DM. Such plants may be appropriate alternatives or adjuncts to available antidiabetic medications.

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Authors and Affiliations

  1. Basic Science Department, Veterinary Medicine Faculty, Shahrekord University, Shahrekord, Iran

    Zeinab Nazarian-Samani

  2. Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales, CF10 3NB, UK

    Robert D. E. Sewell

  3. Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

    Zahra Lorigooini & Mahmoud Rafieian-Kopaei

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  1. Zeinab Nazarian-Samani
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This article is part of the Topical Collection on Pharmacologic Treatment of Type 2 Diabetes

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Nazarian-Samani, Z., Sewell, R.D.E., Lorigooini, Z. et al. Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review. Curr Diab Rep 18, 72 (2018). https://doi.org/10.1007/s11892-018-1042-0

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