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Role of AMP deaminase in diabetic cardiomyopathy

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Abstract

Diabetes mellitus is one of the major causes of ischemic and nonischemic heart failure. While hypertension and coronary artery disease are frequent comorbidities in patients with diabetes, cardiac contractile dysfunction and remodeling occur in diabetic patients even without comorbidities, which is referred to as diabetic cardiomyopathy. Investigations in recent decades have demonstrated that the production of reactive oxygen species (ROS), impaired handling of intracellular Ca2+, and alterations in energy metabolism are involved in the development of diabetic cardiomyopathy. AMP deaminase (AMPD) directly regulates adenine nucleotide metabolism and energy transfer by adenylate kinase and indirectly modulates xanthine oxidoreductase-mediated pathways and AMP-activated protein kinase-mediated signaling. Upregulation of AMPD in diabetic hearts was first reported more than 30 years ago, and subsequent studies showed similar upregulation in the liver and skeletal muscle. Evidence for the roles of AMPD in diabetes-induced fatty liver, sarcopenia, and heart failure has been accumulating. A series of our recent studies showed that AMPD localizes in the mitochondria-associated endoplasmic reticulum membrane as well as the sarcoplasmic reticulum and cytosol and participates in the regulation of mitochondrial Ca2+ and suggested that upregulated AMPD contributes to contractile dysfunction in diabetic cardiomyopathy via increased generation of ROS, adenine nucleotide depletion, and impaired mitochondrial respiration. The detrimental effects of AMPD were manifested at times of increased cardiac workload by pressure loading. In this review, we briefly summarize the expression and functions of AMPD in the heart and discuss the roles of AMPD in diabetic cardiomyopathy, mainly focusing on contractile dysfunction caused by this disorder.

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Funding

TM is funded by Grant 21K08035 from the Japan Society for the Promotion of Science, Tokyo, Japan and a Grant for Scientific Research from Hokkaido University of Science, Sapporo, Japan. HK is funded by Grant 23K07481 from the Japan Society for the Promotion of Science, Tokyo, Japan. MT is funded by Grant 21K08110 from the Japan Society for the Promotion of Science, Tokyo, Japan. AK is funded by Grant 23K06152 from the Japan Society for the Promotion of Science, Tokyo, Japan.

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Authors and Affiliations

  1. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

    Tetsuji Miura, Hidemichi Kouzu & Masaya Tanno

  2. Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 15-4-1, Maeda-7, Teine-Ku, Sapporo, 006-8585, Japan

    Tetsuji Miura

  3. Department of Nursing, Sapporo Medical University School of Health Sciences, Sapporo, Japan

    Masaya Tanno

  4. Department of Pharmacology, Sapporo Medical University School of Medicine, Sapporo, Japan

    Yuki Tatekoshi & Atsushi Kuno

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  1. Tetsuji Miura
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TM conceptualized the topic and wrote the first draft of the manuscript. HK, MT, YK, and AK commented on previous versions of the manuscript. All figures were prepared by TM. All authors read and approved the final manuscript.

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Correspondence to Tetsuji Miura.

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Miura, T., Kouzu, H., Tanno, M. et al. Role of AMP deaminase in diabetic cardiomyopathy. Mol Cell Biochem (2024). https://doi.org/10.1007/s11010-024-04951-z

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