Abstract
Diabetic cardiomyopathy describes decreased myocardial function in diabetic patients in the absence of other heart diseases such as myocardial ischemia and hypertension. Recent studies have defined numerous molecular interactions and signaling events that may account for deleterious changes in mitochondrial dynamics and functions influenced by hyperglycemic stress. A metabolic switch from glucose to fatty acid oxidation to fuel ATP synthesis, mitochondrial oxidative injury resulting from increased mitochondrial ROS production and decreased antioxidant capacity, enhanced mitochondrial fission and defective mitochondrial fusion, impaired mitophagy, and blunted mitochondrial biogenesis are major signatures of mitochondrial pathologies during diabetic cardiomyopathy. This review describes the molecular alterations underlying mitochondrial abnormalities associated with hyperglycemia and discusses their influence on cardiomyocyte viability and function. Based on basic research findings and clinical evidence, diabetic treatment standards and their impact on mitochondrial function, as well as mitochondria-targeted therapies of potential benefit for diabetic cardiomyopathy patients, are also summarized.
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This study was financially supported by grants from the National Natural Science Foundation of China (Nos. 82270279, 82200296, and 82170241) and Special Program for Training Outstanding Young Talents of Chinese Academy of Traditional Chinese Medicine (ZZ16-YQ-021) and Innovative Cultivation Project of Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences (2022s481). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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Zhi, F., Zhang, Q., Liu, L. et al. Novel insights into the role of mitochondria in diabetic cardiomyopathy: molecular mechanisms and potential treatments. Cell Stress and Chaperones 28, 641–655 (2023). https://doi.org/10.1007/s12192-023-01361-w
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DOI: https://doi.org/10.1007/s12192-023-01361-w