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From 3D printing to 3D bioprinting: the material properties of polymeric material and its derived bioink for achieving tissue specific architectures

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Abstract

The application of 3D printing technologies fields for biological tissues, organs, and cells in the context of medical and biotechnology applications requires a significant amount of innovation in a narrow printability range. 3D bioprinting is one such way of addressing critical design challenges in tissue engineering. In a more general sense, 3D printing has become essential in customized implant designing, faithful reproduction of microenvironmental niches, sustainable development of implants, in the capacity to address issues of effective cellular integration, and long-term stability of the cellular constructs in tissue engineering. This review covers various aspects of 3D bioprinting, describes the current state-of-the-art solutions for all aforementioned critical issues, and includes various illustrative representations of technologies supporting the development of phases of 3D bioprinting. It also demonstrates several bio-inks and their properties crucial for being used for 3D printing applications. The review focus on bringing together different examples and current trends in tissue engineering applications, including bone, cartilage, muscles, neuron, skin, esophagus, trachea, tympanic membrane, cornea, blood vessel, immune system, and tumor models utilizing 3D printing technology and to provide an outlook of the future potentials and barriers.

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Acknowledgements

This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 760921 (PANBioRA). KunalMitra will acknowledge the support of NASA Florida Space Grant for this research. He would also acknowledge the help of students LikithaSomasekhar and Amy Vecheck with the graphs. Albert A. Rizvanovwas funded by the subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities. Kazan Federal University was partially supported by the Russian Government Program of Competitive Growth. Arindam Bit is supported by Department of Science and Technology India (INT/RUS/RFBR/P-332) grant and Science and Engineering Research Board India (ECR/2017/001115) Grant.

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Authors and Affiliations

  1. Spartha Medical, Strasbourg, France

    Nihal Engin Vrana

  2. Florida Institute of Technology, Melbourne, USA

    Kunal Mitra

  3. Kazan Federal University, Kazan, Russia

    Albert A. Rizvanov & Valeriya V. Solovyeva

  4. Center of Excellence in Biomaterials and Tissue Engineering, BIOMATEN, Middle East Technical University (METU), Ankara, Turkey

    Ezgi Antmen

  5. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran

    Majid Salehi

  6. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran

    Majid Salehi

  7. Department of Mechanical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Arian Ehterami

  8. UMR 1121, Biomaterials and Bioengineering, INSERM, Strasbourg, France

    Lea Pourchet & Julien Barthes

  9. Université Lyon 1 - CNRS 5246 ICBMS, Lyon Cedex, France

    Christophe A. Marquette

  10. Akershus University Hospital and University of Oslo, Oslo, Norway

    Magnus von Unge

  11. Center for Clinical Research, Uppsala University, Vasteras, Uppsala, Sweden

    Magnus von Unge

  12. Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Taoyuan City, Taiwan

    Chi-Yun Wang & Po-Liang Lai

  13. Bone and Joint Research Center, Chang Gung Memorial Hospital, Taoyuan City, Taiwan

    Chi-Yun Wang & Po-Liang Lai

  14. National Institute of Technology, Raipur, India

    Sharda Gupta & Arindam Bit

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  1. Nihal Engin Vrana
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Correspondence to Nihal Engin Vrana or Arindam Bit.

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Vrana, N., Gupta, S., Mitra, K. et al. From 3D printing to 3D bioprinting: the material properties of polymeric material and its derived bioink for achieving tissue specific architectures. Cell Tissue Bank 23, 417–440 (2022). https://doi.org/10.1007/s10561-021-09975-z

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