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Unique features of pregnancy-related meningiomas: lessons learned from 148 reported cases and theoretical implications of a prolactin modulated pathogenesis

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Abstract

Meningiomas are some of the most frequently encountered adult intracranial tumors. Dramatic flare ups in size may occasionally be observed during pregnancy, leading to complicated clinical scenarios, with profound effects and substantial risks for both the mother’s and the fetus’s well-being. Despite the fact that such changes have largely been attributed to progesterone-based mechanisms, recent studies have put this theory into question or defied it. In order to assess these particular tumors carefully and to try and clarify the pathophysiology of such pregnancy-related meningioma growth, an in-depth review of the pertinent literature was undertaken. Based on clinical, radiographic, and pathological data gathered from 148 reported cases, we have found several unique features characterizing these pregnancy-related meningiomas. The presence of such observed features was found to be of high statistical significance when compared to their expected prevalence in the general population and included the following: (1) parasellar location, (2) anterior circulation blood supply, (3) visual symptoms at presentation, (4) high rate of clear-cell and chordoid morphology. A hypothesis is developed that these features are related to hormonal influences of the pituitary gland, and we discuss that this may be due to elevated prolactin levels. We encourage further research to test this exciting new theory.

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References

  1. Abbassi-Ghanavati M, Greer LG, Cunningham FG (2009) Pregnancy and laboratory studies: a reference table for clinicians. Obstet Gynecol 114:1326–1331. doi:10.1097/AOG.1320b1013e3181c1322bde1328

    Article  CAS  PubMed  Google Scholar 

  2. Abry E, Thomassen IO, Salvesen OO, Torp SH (2010) The significance of Ki-67/MIB-1 labeling index in human meningiomas: a literature study. Pathol Res Pract 206:810–815. doi:10.1016/j.prp.2010.1009.1002

    Article  CAS  PubMed  Google Scholar 

  3. al-Habori M, Peak M, Thomas TH, Agius L (1992) The role of cell swelling in the stimulation of glycogen synthesis by insulin. Biochem J 282:789–796

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Andersen L, Friis S, Hallas J, Ravn P, Schroder HD, Gaist D (2013) Hormone replacement therapy increases the risk of cranial meningioma. Eur J Cancer 49:3303–3310. doi:10.1016/j.ejca.2013.05.026

    Article  CAS  PubMed  Google Scholar 

  5. Anderson D, Khalil M (1981) Meningioma and the ophthalmologist. A review of 80 cases. Ophthalmology 88:1004–1009

    Article  CAS  PubMed  Google Scholar 

  6. Bakar B, Sav A, Tekkok IH (2010) Giant chordoid meningioma symptomatic immediately after pregnancy: report of a rare case. Clin Neuropathol 29:163–168

    Article  CAS  PubMed  Google Scholar 

  7. Balki M, Manninen PH (2004) Craniotomy for suprasellar meningioma in a 28-week pregnant woman without fetal heart rate monitoring. Can J Anaesth 51:573–576. doi:10.1007/bf03018400

    Article  PubMed  Google Scholar 

  8. Barresi V (2011) Angiogenesis in meningiomas. Brain Tumor Pathol 28:99–106. doi:10.1007/s10014-10010-10012-10012

    Article  CAS  PubMed  Google Scholar 

  9. Bassiouni H, Asgari S, Konig HJ, Stolke D (2008) Meningiomas of the falcotentorial junction: selection of the surgical approach according to the tumor type. Surg Neurol 69:339–349, discussion 349

    Article  PubMed  Google Scholar 

  10. Baxter DS, Smith P, Stewart K, Murphy M (2009) Clear cell meningioma presenting as rapidly deteriorating visual field and acuity during pregnancy. J Clin Neurosci 16:1502–1504. doi:10.1016/j.jocn.2009.1502

    Article  CAS  PubMed  Google Scholar 

  11. Benson VS, Kirichek O, Beral V, Green J (2015) Menopausal hormone therapy and central nervous system tumor risk: large UK prospective study and meta-analysis. Int J Cancer 136:2369–2377. doi:10.1002/ijc.29274

    Article  CAS  PubMed  Google Scholar 

  12. Bhavsar SK, Hosseinzadeh Z, Merches K, Gu S, Broer S, Lang F (2011) Stimulation of the amino acid transporter SLC6A19 by JAK2. Biochem Biophys Res Commun 414:456–461. doi:10.1016/j.bbrc.2011.09.074

    Article  CAS  PubMed  Google Scholar 

  13. Bickerstaff ER, Small JM, Guest IA (1958) The relapsing course of certain meningiomas in relation to pregnancy and menstruation. J Neurol Neurosurg Psychiatry 21:89–91

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Boyle-Walsh E, Shenkin A, White MC, Fraser WD (1995) Effect of glycoprotein and protein hormones on human meningioma cell proliferation in vitro. J Endocrinol 145:155–161

    Article  CAS  PubMed  Google Scholar 

  15. Brandis A, Mirzai S, Tatagiba M, Walter GF, Samii M, Ostertag H (1993) Immunohistochemical detection of female sex hormone receptors in meningiomas: correlation with clinical and histological features. Neurosurgery 33:212–217, discussion 217-218

    Article  CAS  PubMed  Google Scholar 

  16. Breves JP, McCormick SD, Karlstrom RO (2014) Prolactin and teleost ionocytes: new insights into cellular and molecular targets of prolactin in vertebrate epithelia. Gen Comp Endocrinol 203:21–28. doi:10.1016/j.ygcen.2013.12.014

    Article  CAS  PubMed  Google Scholar 

  17. Britt K, Ashworth A, Smalley M (2007) Pregnancy and the risk of breast cancer. Endocr Relat Cancer 14:907–933. doi:10.1677/ERC-07-0137

    Article  CAS  PubMed  Google Scholar 

  18. Cahill DW, Bashirelahi N, Solomon LW, Dalton T, Salcman M, Ducker TB (1984) Estrogen and progesterone receptors in meningiomas. J Neurosurg 60:985–993. doi:10.3171/jns.1984.60.5.0985

    Article  CAS  PubMed  Google Scholar 

  19. Carroll RS, Schrell UM, Zhang J, Dashner K, Nomikos P, Fahlbusch R, Black PM (1996) Dopamine D1, dopamine D2, and prolactin receptor messenger ribonucleic acid expression by the polymerase chain reaction in human meningiomas. Neurosurgery 38:367–375

    Article  CAS  PubMed  Google Scholar 

  20. Carroll RS, Zhang J, Dashner K, Black PM (1995) Progesterone and glucocorticoid receptor activation in meningiomas. Neurosurgery 37:92–97

    Article  CAS  PubMed  Google Scholar 

  21. Cattoretti G, Becker MH, Key G, Duchrow M, Schluter C, Galle J, Gerdes J (1992) Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 168:357–363

    Article  CAS  PubMed  Google Scholar 

  22. Chacko JG, Miller JL, Angtuaco EJ (2010) Spontaneous postpartum resolution of vision loss caused by a progesterone receptor-positive tuberculum sellae meningioma. J Neuroophthalmol 30:132–134. doi:10.1097/WNO.1090b1013e3181da1099d1059

    Article  PubMed  Google Scholar 

  23. Chen D, Song M, Mohamad O, Yu SP (2014) Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells. BMC Cancer 14:716. doi:10.1186/1471-2407-14-716

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  24. Ciccarelli E, Razzore P, Gaia D, Todaro C, Longo A, Forni M, Ghe C, Camanni F, Muccioli G, Faccani G et al (2001) Hyperprolactinaemia and prolactin binding in benign intracranial tumours. J Neurosurg Sci 45:70–74

    CAS  PubMed  Google Scholar 

  25. Clapp C, Thebault S, Macotela Y, Moreno-Carranza B, Triebel J, Martinez de la Escalera G (2015) Regulation of blood vessels by prolactin and vasoinhibins. Adv Exp Med Biol 846:83–95. doi:10.1007/978-3-319-12114-7_4

    Article  CAS  PubMed  Google Scholar 

  26. Claus EB, Black PM, Bondy ML, Calvocoressi L, Schildkraut JM, Wiemels JL, Wrensch M (2007) Exogenous hormone use and meningioma risk: what do we tell our patients? Cancer 110:471–476. doi:10.1002/cncr.22783

    Article  PubMed  Google Scholar 

  27. Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM (2005) Epidemiology of intracranial meningioma. Neurosurgery 57:1088–1095, discussion 1088-1095

    Article  PubMed  Google Scholar 

  28. Cohen-Gadol AA, Friedman JA, Friedman JD, Tubbs RS, Munis JR, Meyer FB (2009) Neurosurgical management of intracranial lesions in the pregnant patient: a 36-year institutional experience and review of the literature. J Neurosurg 111:1150–1157. doi:10.3171/2009.1153.JNS081160

    Article  PubMed  Google Scholar 

  29. Commins DL, Atkinson RD, Burnett ME (2007) Review of meningioma histopathology. Neurosurg Focus 23:E3

    Article  PubMed  Google Scholar 

  30. Corbacho AM, Martinez De La Escalera G, Clapp C (2002) Roles of prolactin and related members of the prolactin/growth hormone/placental lactogen family in angiogenesis. J Endocrinol 173:219–238

    Article  CAS  PubMed  Google Scholar 

  31. Couce ME, Aker FV, Scheithauer BW (2000) Chordoid meningioma: a clinicopathologic study of 42 cases. Am J Surg Pathol 24:899–905

    Article  CAS  PubMed  Google Scholar 

  32. Cushing H EL (1938) Meningiomas: their classification, regional behavior, life history and surgical end results. Charles C Thomas, City

  33. Custer B, Longstreth WT Jr, Phillips LE, Koepsell TD, Van Belle G (2006) Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study. BMC Cancer 6:152

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  34. David J. Fiorella VRD, Cameron G. Mcdougall, Robert F. Spetzler, Felipe C. Albuquerque (2009) Preoperative embolization of meningiomas. In: Lee JH (ed) Meningiomas: diagnosis, treatment, and outcome. Springer - Verlag, City, p 95–96

  35. David O. Okonkwo ERL, Jr. (2009) Meningioma: historical perspective. In: Lee JH (ed) Meningiomas: diagnosis, treatment and outcomes. Springer - Verlag, City, p 6

  36. Denise M. D. Abech JFSP-L, Carolina G. S. Leães, Rosalva T. Meurer, Lígia M. Barbosa-Coutinho, Nelson P. Ferreira, Miriam C. Oliveira (2012) Cell replication and angiogenesis in central nervous system tumors and their relationship with the expression of tissue prolactin and hyperprolactinemia. Open J Pathol 2:50–57

  37. Dombro RS, Bender AS, Norenberg MD (2000) Association between cell swelling and glycogen content in cultured astrocytes. Int J Dev Neurosci 18:161–169

    Article  CAS  PubMed  Google Scholar 

  38. Doyle S, Messiou C, Rutherford JM, Dineen RA (2009) Cancer presenting during pregnancy: radiological perspectives. Clin Radiol 64:857–871. doi:10.1016/j.crad.2008.1008.1020

    Article  CAS  PubMed  Google Scholar 

  39. Dubel GJ, Ahn SH, Soares GM (2013) Contemporary endovascular embolotherapy for meningioma. Semin Intervent Radiol 30:263–277. doi:10.1055/s-0033-1353479

    Article  PubMed  PubMed Central  Google Scholar 

  40. Ebner FH, Bornemann A, Wilhelm H, Ernemann U, Honegger J (2008) Tuberculum sellae meningioma symptomatic during pregnancy: pathophysiological considerations. Acta Neurochir (Wien) 150:189–193. doi:10.1007/s00701-00007-01417-00705, discussion 193

    Article  CAS  Google Scholar 

  41. Fewings PE, Battersby RD, Timperley WR (2000) Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? J Neurosurg 92:401–405. doi:10.3171/jns.2000.92.3.0401

    Article  CAS  PubMed  Google Scholar 

  42. Findling JW, Kehoe ME, Raff H (2004) Identification of patients with Cushing’s disease with negative pituitary adrenocorticotropin gradients during inferior petrosal sinus sampling: prolactin as an index of pituitary venous effluent. J Clin Endocrinol Metab 89:6005–6009

    Article  CAS  PubMed  Google Scholar 

  43. Freeman ME, Kanyicska B, Lerant A, Nagy G (2000) Prolactin: structure, function, and regulation of secretion. Physiol Rev 80:1523–1631

    Article  CAS  PubMed  Google Scholar 

  44. Gazzeri R, Galarza M, Gazzeri G (2007) Growth of a meningioma in a transsexual patient after estrogen-progestin therapy. N Engl J Med 357:2411–2412. doi:10.1056/NEJMc071938

    Article  CAS  PubMed  Google Scholar 

  45. Gebel J, Frank JI (1995) An unusual case of postpartum stroke. J Stroke Cerebrovasc Dis 5:235–237. doi:10.1016/S1052-3057(1010)80195-80198

    Article  CAS  PubMed  Google Scholar 

  46. Giannini A, Bricchi M (1999) Posterior fossa surgery in the sitting position in a pregnant patient with cerebellopontine angle meningioma. Br J Anaesth 82:941–944

    Article  CAS  PubMed  Google Scholar 

  47. Han Y, Watling D, Rogers NC, Stark GR (1997) JAK2 and STAT5, but not JAK1 and STAT1, are required for prolactin-induced beta-lactoglobulin transcription. Mol Endocrinol 11:1180–1188. doi:10.1210/mend.11.8.9952

    CAS  PubMed  Google Scholar 

  48. Hatiboglu MA, Cosar M, Iplikcioglu AC, Ozcan D (2008) Sex steroid and epidermal growth factor profile of giant meningiomas associated with pregnancy. Surg Neurol 69:356–362. doi:10.1016/j.surneu.2007.03.013, discussion 362-353

    Article  PubMed  Google Scholar 

  49. Helseth A, Mork SJ, Glattre E (1989) Neoplasms of the central nervous system in Norway. V. Meningioma and cancer of other sites. An analysis of the occurrence of multiple primary neoplasms in meningioma patients in Norway from 1955 through 1986. Apmis 97:738–744

    Article  CAS  PubMed  Google Scholar 

  50. Hirohata M, Abe T, Morimitsu H, Fujimura N, Shigemori M, Norbash AM (2003) Preoperative selective internal carotid artery dural branch embolisation for petroclival meningiomas. Neuroradiology 45:656–660

    Article  CAS  PubMed  Google Scholar 

  51. Hosseinzadeh Z, Bhavsar SK, Lang F (2012) Down-regulation of the myoinositol transporter SMIT by JAK2. Cell Physiol Biochem 30:1473–1480. doi:10.1159/000343335

    Article  CAS  PubMed  Google Scholar 

  52. Hosseinzadeh Z, Bhavsar SK, Lang F (2012) Downregulation of ClC-2 by JAK2. Cell Physiol Biochem 29:737–742. doi:10.1159/000178560

    Article  CAS  PubMed  Google Scholar 

  53. Hsu DW, Efird JT, Hedley-Whyte ET (1997) Progesterone and estrogen receptors in meningiomas: prognostic considerations. J Neurosurg 86:113–120. doi:10.3171/jns.1997.86.1.0113

    Article  CAS  PubMed  Google Scholar 

  54. Idowu OE, Shokunbi MT, Amanor-Boadu SD, Roberts OA, Eyo C (2004) Surgical management of tuberculum sellae meningioma in a patient with a twin pregnancy: case report. Surg Neurol 62:60–63. doi:10.1016/j.surneu.2003.07.007

    Article  CAS  PubMed  Google Scholar 

  55. Isla A, Alvarez F, Gonzalez A, Garcia-Grande A, Perez-Alvarez M, Garcia-Blazquez M (1997) Brain tumor and pregnancy. Obstet Gynecol 89:19–23

    Article  CAS  PubMed  Google Scholar 

  56. Ismail K, Coakham HB, Walters FJ (1998) Intracranial meningioma with progesterone positive receptors presenting in late pregnancy. Eur J Anaesthesiol 15:106–109

    Article  CAS  PubMed  Google Scholar 

  57. Jain D, Sharma MC, Sarkar C, Suri V, Garg A, Singh M, Sharma BS, Mahapatra AK (2007) Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases. J Neurooncol 81:315–321. doi:10.1007/s11060-006-9237-7

    Article  CAS  PubMed  Google Scholar 

  58. Jhawar BS, Ranger A, Steven D, Del Maestro RF (2003) Risk factors for intracranial hemorrhage among full-term infants: a case-control study. Neurosurgery 52:581–590, discussion 588-590

    Article  PubMed  Google Scholar 

  59. Jimenez-Hakim E, el-Azouzi M, Black PM (1993) The effect of prolactin and bombesin on the growth of meningioma-derived cells in monolayer culture. J Neurooncol 16:185–190

    Article  CAS  PubMed  Google Scholar 

  60. Johnson MD, O’Connell M (2013) Na-K-2Cl cotransporter and aquaporin 1 in arachnoid granulations, meningiomas, and meningiomas invading dura. Hum Pathol 44:1118–1124. doi:10.1016/j.humpath.2012.09.020

    Article  CAS  PubMed  Google Scholar 

  61. Johnson N, Sermer M, Lausman A, Maxwell C (2009) Obstetric outcomes of women with intracranial neoplasms. Int J Gynaecol Obstet 105:56–59. doi:10.1016/j.ijgo.2008.1011.1037

    Article  PubMed  Google Scholar 

  62. Kanaan I, Jallu A, Kanaan H (2003) Management strategy for meningioma in pregnancy: a clinical study. Skull Base 13:197–203. doi:10.1055/s-2004-817695

    Article  PubMed  PubMed Central  Google Scholar 

  63. Kasper EM, Hess PE, Silasi M, Lim KH, Gray J, Reddy H, Gilmore L, Kasper B (2010) A pregnant female with a large intracranial mass: reviewing the evidence to obtain management guidelines for intracranial meningiomas during pregnancy. Surg Neurol Int 1:95. doi:10.4103/2152-7806.74242

    Article  PubMed  PubMed Central  Google Scholar 

  64. Kerschbaumer J, Freyschlag CF, Stockhammer G, Taucher S, Maier H, Thome C, Seiz-Rosenhagen M (2015) Hormone-dependent shrinkage of a sphenoid wing meningioma after pregnancy: case report. J Neurosurg: 1–4 doi:10.3171/2014.12.jns142112

  65. Khong SY, Leach J, Greenwood C (2007) Meningioma mimicking puerperal psychosis. Obstet Gynecol 109:515–516

    Article  PubMed  Google Scholar 

  66. Korshunov A, Shishkina L, Golanov A (2003) Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome. Int J Cancer 104:728–734

    Article  CAS  PubMed  Google Scholar 

  67. Krovvidi H, Sharma S, Danks J (2008) Postpartum neurologic deficit: an intracranial cause. Int J Obstet Anesth 17:378–379. doi:10.1016/j.ijoa.2008.1006.1002

    Article  PubMed  Google Scholar 

  68. Kumar S, Gupta V, Khandelwal N (2013) Hemorrhage in meningioma: an unwanted outcome of pregnancy. Neurol India 61:329–330. doi:10.4103/0028-3886.115098

    Article  PubMed  Google Scholar 

  69. Kurdoglu Z, Cetin O, Gulsen I, Dirik D, Bulut MD (2014) Intracranial meningioma diagnosed during pregnancy caused maternal death. Case Rep Med 158326:10

    Google Scholar 

  70. Lee E, Grutsch J, Persky V, Glick R, Mendes J, Davis F (2006) Association of meningioma with reproductive factors. Int J Cancer 119:1152–1157. doi:10.1002/ijc.21950

    Article  CAS  PubMed  Google Scholar 

  71. Lee JH (2009) Meningiomas: diagnosis, treatment and outcomes. Springer - Verlag, City

  72. Lee KH, Lall RR, Chandler JP, Bigio EH, Mao Q (2013) Pineal chordoid meningioma complicated by repetitive hemorrhage during pregnancy: case report and literature review. Neuropathology 33:192–198. doi:10.1111/j.1440-1789.2012.01337.x

    Article  PubMed  Google Scholar 

  73. Litan A, Langhans SA (2015) Cancer as a channelopathy: ion channels and pumps in tumor development and progression. Front Cell Neurosci 9:86. doi:10.3389/fncel.2015.00086

    Article  PubMed  PubMed Central  Google Scholar 

  74. Loretz CA, Bern HA (1982) Prolactin and osmoregulation in vertebrates. An update. Neuroendocrinology 35:292–304

    Article  CAS  PubMed  Google Scholar 

  75. Lusis EA, Scheithauer BW, Yachnis AT, Fischer BR, Chicoine MR, Paulus W, Perry A (2012) Meningiomas in pregnancy: a clinicopathologic study of 17 cases. Neurosurgery 71:951–961. doi:10.1227/NEU.0b013e31826adf65

    Article  PubMed  Google Scholar 

  76. Mathis S, Bataille B, Boucebci S, Jeantet M, Ciron J, Vandamme L, Neau JP (2013) A rare cause of stroke in young adults: occlusion of the middle cerebral artery by a meningioma postpartum. Case Rep Neurol Med 652538:2

    Google Scholar 

  77. Mealey J Jr, Carter JE (1968) Spinal cord tumor during pregnancy. Obstet Gynecol 32:204–209

    PubMed  Google Scholar 

  78. Mendes GA, Pereira-Lima JF, Kohek MB, Trott G, Di Domenico M, Ferreira NP, Oliveira Mda C (2013) Prolactin gene expression in primary central nervous system tumors. J Negat Results Biomed 12:4. doi:10.1186/1477-5751-1112-1184

    Article  PubMed  PubMed Central  Google Scholar 

  79. Michelsen JJ, New PF (1969) Brain tumour and pregnancy. J Neurol Neurosurg Psychiatry 32:305–307

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Moscovici S, Fraifeld S, Cohen JE, Dotan S, Elchalal U, Shoshan Y, Spektor S (2014) Parasellar meningiomas in pregnancy: surgical results and visual outcomes. World Neurosurg 82:e503–e512. doi:10.1016/j.wneu.2013.06.019

    Article  PubMed  Google Scholar 

  81. Muccioli G, Ghe C, Faccani G, Lanotte M, Forni M, Ciccarelli E (1997) Prolactin receptors in human meningiomas: characterization and biological role. J Endocrinol 153:365–371

    Article  CAS  PubMed  Google Scholar 

  82. Nakamura M, Samii M (2003) Surgical management of a meningioma in the retrosellar region. Acta Neurochir (Wien) 145:215–219. doi:10.1007/s00701-002-1053-z, discussion 219-220

    Article  CAS  Google Scholar 

  83. Narayansingh GV, Ramsewak S, Cross JN, Adam RU, Kissoon W (1992) Worsening neurological status in late pregnancy: consider meningioma. Postgrad Med J 68:486

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Nassehi D (2013) Intracranial meningiomas, the VEGF-A pathway, and peritumoral brain oedema. Dan Med J 60:B4626

    PubMed  Google Scholar 

  85. Newton HB (2016) Handbook of Neuro-Oncology Neuroimaging. Elsevier, New-York

    Google Scholar 

  86. Nishio S, Morioka T, Suzuki S, Takeshita I, Ikezaki K, Fukui M, Nakano H (1996) Primary brain tumours manifesting during pregnancy: presentation of six cases and a review of the literature. J Clin Neurosci 3:334–337

    Article  CAS  PubMed  Google Scholar 

  87. Nishioka T, Kondo A, Aoyama I, Shimotake K, Takahashi J, Kusaka H (1989) Primary interosseous meningioma associated with pregnancy—case report. Neurol Med Chir (Tokyo) 29:619–623

    Article  CAS  Google Scholar 

  88. Ossama Al-Mefty SIA, Georges F. Haddad (2011) Meningiomas. In: Winn HR (ed) Youmans Neurological Surgery 6th edn. Saunders, City

  89. Ostrom QT, Gittleman H, Fulop J, Liu M, Blanda R, Kromer C, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS (2015) CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012. Neuro Oncol 17(Suppl 4):iv1–iv62. doi:10.1093/neuonc/nov189

    Article  PubMed  PubMed Central  Google Scholar 

  90. Otton GR, Giles W, Walters WA (1997) Large meningioma complicating pregnancy. Aust N Z J Obstet Gynaecol 37:466–469

    Article  CAS  PubMed  Google Scholar 

  91. Owens MA, Craig BM, Egan KM, Reed DR (2015) Birth desires and intentions of women diagnosed with a meningioma. J Neurosurg 122:1151–1156. doi:10.3171/2014.1111.JNS14522

    Article  PubMed  PubMed Central  Google Scholar 

  92. Patel S, Sharan V (2010) Meningioma in pregnancy. J Obstet Gynaecol 30:56–57. doi:10.3109/01443610903267465

    Article  CAS  PubMed  Google Scholar 

  93. Pearson BE, Markert JM, Fisher WS, Guthrie BL, Fiveash JB, Palmer CA, Riley K (2008) Hitting a moving target: evolution of a treatment paradigm for atypical meningiomas amid changing diagnostic criteria. Neurosurg Focus 24:E3. doi:10.3171/FOC/2008/3124/3175/E3173

    Article  PubMed  Google Scholar 

  94. Perry A, Cai DX, Scheithauer BW, Swanson PE, Lohse CM, Newsham IF, Weaver A, Gutmann DH (2000) Merlin, DAL-1, and progesterone receptor expression in clinicopathologic subsets of meningioma: a correlative immunohistochemical study of 175 cases. J Neuropathol Exp Neurol 59:872–879

    Article  CAS  PubMed  Google Scholar 

  95. Perry A LD, Scheithauer BW, Budka H, von Diemling A (2000) Meningioma. In: Kleihues P CW (ed) Pathology and genetics of tumours of the nervous system World Health Organisation classification of tumours IARC Press, City, p 176–184

  96. Perry A LD, Scheithauer BW, Budka H, von Diemling A (2007) Meningiomas. In: Louis DN OH, Wiestler OD (ed) World Health Organization Classification of Tumours of the Central Nervous System. IARC, City, p 164–172

  97. Perry A, Stafford SL, Scheithauer BW, Suman VJ, Lohse CM (1997) Meningioma grading: an analysis of histologic parameters. Am J Surg Pathol 21:1455–1465

    Article  CAS  PubMed  Google Scholar 

  98. Pettorini BL, Park YS, Caldarelli M, Massimi L, Tamburrini G, Di Rocco C (2008) Radiation-induced brain tumours after central nervous system irradiation in childhood: a review. Childs Nerv Syst 24:793–805. doi:10.1007/s00381-008-0631-7

    Article  PubMed  Google Scholar 

  99. Pliskow S, Herbst SJ, Saiontz HA, Cove H, Ackerman RT (1995) Intracranial meningioma with positive progesterone receptors. A case report. J Reprod Med 40:154–156

    CAS  PubMed  Google Scholar 

  100. Prayson RA (2009) Pathology of meningiomas. In: Lee JH (ed) Meningiomas Diagnosis, treatment and outcomes. Springer - Verlag, City, p 34

  101. pregnancy CPNsi (1974) Neurologic surgery in pregnancy. In: Barber HR GE, eds. (ed) Surgical Disease in Pregnancy WB Saunders, City, p 203–224

  102. Rand CW, Andler M (1950) Tumors of the brain complicating pregnancy. Arch Neurol Psychiatr 63:1–41, illust

    Article  CAS  Google Scholar 

  103. Rasmussen LJ, Muller HS, Jorgensen B, Pedersen SF, Hoffmann EK (2015) Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells. Am J Physiol Cell Physiol 308:C101–C110. doi:10.1152/ajpcell.00070.2014

    Article  CAS  PubMed  Google Scholar 

  104. Rodriguez-Porcel F, Hughes I, Anderson D, Lee J, Biller J (2013) Foster Kennedy Syndrome Due to Meningioma Growth during Pregnancy. Front Neurol 4

  105. Rodriguez EM, Blazquez JL, Guerra M (2010) The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: the former opens to the portal blood and the latter to the cerebrospinal fluid. Peptides 31:757–776. doi:10.1016/j.peptides.2010.01.003

    Article  CAS  PubMed  Google Scholar 

  106. Roelvink NC, Kamphorst W, van Alphen HA, Rao BR (1987) Pregnancy-related primary brain and spinal tumors. Arch Neurol 44:209–215

    Article  CAS  PubMed  Google Scholar 

  107. Rohringer M, Sutherland GR, Louw DF, Sima AA (1989) Incidence and clinicopathological features of meningioma. J Neurosurg 71:665–672

    Article  CAS  PubMed  Google Scholar 

  108. Sadetzki S, Flint-Richter P, Ben-Tal T, Nass D (2002) Radiation-induced meningioma: a descriptive study of 253 cases. J Neurosurg 97:1078–1082. doi:10.3171/jns.2002.97.5.1078

    Article  PubMed  Google Scholar 

  109. Sahu S, Lata I, Gupta D (2010) Management of pregnant female with meningioma for craniotomy. J Neurosci Rural Pract 1:35–37. doi:10.4103/0976-3147.63101

    Article  PubMed  PubMed Central  Google Scholar 

  110. Saitoh Y, Oku Y, Izumoto S, Go J (1989) Rapid growth of a meningioma during pregnancy: relationship with estrogen and progesterone receptors--case report. Neurol Med Chir (Tokyo) 29:440–443

    Article  CAS  Google Scholar 

  111. Schlehofer B, Blettner M, Wahrendorf J (1992) Association between brain tumors and menopausal status. J Natl Cancer Inst 84:1346–1349

    Article  CAS  PubMed  Google Scholar 

  112. Schnitt SJ, Vogel H (1986) Meningiomas. Diagnostic value of immunoperoxidase staining for epithelial membrane antigen. Am J Surg Pathol 10:640–649

    Article  CAS  PubMed  Google Scholar 

  113. Schoenberg BS, Christine BW, Whisnant JP (1975) Nervous system neoplasms and primary malignancies of other sites. The unique association between meningiomas and breast cancer. Neurology 25:705–712

    Article  CAS  PubMed  Google Scholar 

  114. Scott A, Sharkawi E, Micallef C, Johns P, Grant L (2008) Chordoid meningioma presenting as painful orbital apex syndrome in pregnancy. Int Ophthalmol 28:355–357

    Article  PubMed  Google Scholar 

  115. Selvaraj NG, Omi E, Gibori G, Rao MC (2000) Janus kinase 2 (JAK2) regulates prolactin-mediated chloride transport in mouse mammary epithelial cells through tyrosine phosphorylation of Na+-K+-2Cl- cotransporter. Mol Endocrinol 14:2054–2065. doi:10.1210/mend.14.12.0568

    CAS  PubMed  Google Scholar 

  116. Shitara S, Nitta N, Fukami T, Nozaki K (2012) Tuberculum sellae meningioma causing progressive visual impairment during pregnancy. Case report. Neurol Med Chir (Tokyo) 52:607–611

    Article  Google Scholar 

  117. Smith JS, Quinones-Hinojosa A, Harmon-Smith M, Bollen AW, McDermott MW (2005) Sex steroid and growth factor profile of a meningioma associated with pregnancy. Can J Neurol Sci 32:122–127

    Article  PubMed  Google Scholar 

  118. Soares Leaes CG, Filho AP, Pereira Lima JF, Dallago CM, Batista RL, Barbosa-Coutinho LM, Ferreira NP, da Costa OM (2007) Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication. Brain Tumor Pathol 24:41–46. doi:10.1007/s10014-007-0220-6

    Article  PubMed  CAS  Google Scholar 

  119. Spring KR (1998) Routes and mechanism of fluid transport by epithelia. Annu Rev Physiol 60:105–119. doi:10.1146/annurev.physiol.60.1.105

    Article  CAS  PubMed  Google Scholar 

  120. Tilzer LL, Plapp FV, Evans JP, Stone D, Alward K (1982) Steroid receptor proteins in human meningiomas. Cancer 49:633–636

    Article  CAS  PubMed  Google Scholar 

  121. Turner KL, Sontheimer H (2014) Cl- and K+ channels and their role in primary brain tumour biology. Philos Trans R Soc Lond B Biol Sci 369:20130095. doi:10.1098/rstb.2013.0095

    Article  PubMed  PubMed Central  Google Scholar 

  122. Vadivelu S, Sharer L, Schulder M (2010) Regression of multiple intracranial meningiomas after cessation of long-term progesterone agonist therapy. J Neurosurg 112:920–924. doi:10.3171/2009.8.JNS09201

    Article  CAS  PubMed  Google Scholar 

  123. Vaquero J, Marcos ML, Martinez R, Bravo G (1983) Estrogen- and progesterone-receptor proteins in intracranial tumors. Surg Neurol 19:11–13

    Article  CAS  PubMed  Google Scholar 

  124. Verheecke M, Halaska MJ, Lok CA, Ottevanger PB, Fruscio R, Dahl-Steffensen K, Kolawa W, Gziri MM, Han SN, Van Calsteren K et al (2014) Primary brain tumours, meningiomas and brain metastases in pregnancy: report on 27 cases and review of literature. Eur J Cancer 50:1462–1471. doi:10.1016/j.ejca.2014.1402.1018

    Article  PubMed  Google Scholar 

  125. Verheijen FM, Sprong M, Jacobs HM, Donker GH, Amelink GJ, Thijssen JH, Blankenstein MA (2001) Progesterone receptor isoform expression in human meningiomas. Eur J Cancer 37:1488–1495

    Article  CAS  PubMed  Google Scholar 

  126. Wahab M, Al-Azzawi F (2003) Meningioma and hormonal influences. Climacteric 6:285–292

    Article  CAS  PubMed  Google Scholar 

  127. Waldron JS, Sughrue ME, Hetts SW, Wilson SP, Mills SA, McDermott MW, Dowd CF, Parsa AT (2011) Embolization of skull base meningiomas and feeding vessels arising from the internal carotid circulation. Neurosurgery 68:162–169. doi:10.1227/NEU.1220b1013e3181fe1222de1229, discussion 169

    Article  PubMed  Google Scholar 

  128. Weyand RD, Mac CC, Wilson RB (1951) The effect of pregnancy on intracranial meningiomas occurring about the optic chiasm. Surg Clin North Am 31:1225–1233

    Article  CAS  PubMed  Google Scholar 

  129. Wigertz A, Lonn S, Mathiesen T, Ahlbom A, Hall P, Feychting M, Swedish Interphone Study G (2006) Risk of brain tumors associated with exposure to exogenous female sex hormones. Am J Epidemiol 164:629–636. doi:10.1093/aje/kwj254

    Article  PubMed  Google Scholar 

  130. Wrensch M, Minn Y, Chew T, Bondy M, Berger MS (2002) Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro Oncol 4:278–299

    Article  PubMed  PubMed Central  Google Scholar 

  131. Zoli M, Faustini-Fustini M, Mazzatenta D, Pasquini E, Frank G (2012) Tuberculum sellae meningioma growing during pregnancy: a difficult decision-making process. J Clin Endocrinol Metab 97:1418–1419. doi:10.1210/jc.2012-1155

    Article  CAS  PubMed  Google Scholar 

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  1. Departments of Surgery, Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA

    Yosef Laviv, Victoria Ohla & Ekkehard M. Kasper

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Laviv, Y., Ohla, V. & Kasper, E.M. Unique features of pregnancy-related meningiomas: lessons learned from 148 reported cases and theoretical implications of a prolactin modulated pathogenesis. Neurosurg Rev 41, 95–108 (2018). https://doi.org/10.1007/s10143-016-0762-3

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