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Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication

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Abstract

The role of prolactin (PRL) in the CNS remains uncertain. We evaluated the presence of hyperprolactinemia, intracellular prolactin (ICP), and prolactin receptor (PRL-R) in primary CNS tumors, and their relationship with cellular replication with a prospective cross-sectional study of 82 consecutive patients with primary CNS tumors admitted for neurosurgical resection between October 2003 and September 2005. Patients submitted to a questionnaire, and venous blood samples were obtained for measurement of serum PRL and TSH. Immunohistochemical analyses were performed to evaluate the presence of ICP, PRL-R, and Ki-67. Serum PRL levels ranged from 2 to 70 ng/ml, and hyperprolactinemia was detected in 25 cases (30.5%). ICP was detected in 18 patients (21.9%), in whom PRL ranged from 2 to 32 ng/ml. A positive correlation was found between PRL levels and the presence of ICP (Student's t test, P = 0.022). The PRL-R was observed immunohistochemically in 32 cases (39%). The frequencies of hyperprolactinemia, ICP, and PRL-R were similar across the several histological types of CNS tumors. Ki-67 index was similar in all groups. Hyperprolactinemia and intracellular presence of PRL and PRL-R were common findings in this population, suggesting a role for PRL in CNS tumor genesis.

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Authors and Affiliations

  1. Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology – Complexo Hospitalar Santa Casa of Porto Alegre/RS, Rua Dona Mimi Moro, 40 90480-050, Porto Alegre, RS, Brazil

    Carolina Garcia Soares Leães, Arthur Pereira Filho, Júlia F.S. Pereira Lima, Cristina Micheletto Dallago, Rafael Loch Batista, Lígia M. Barbosa-Coutinho, Nelson Pires Ferreira & Miriam da Costa Oliveira

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  1. Carolina Garcia Soares Leães
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  2. Arthur Pereira Filho
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  3. Júlia F.S. Pereira Lima
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Correspondence to Miriam da Costa Oliveira.

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Soares Leães, C., Filho, A., Pereira Lima, J. et al. Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication. Brain Tumor Pathol 24, 41–46 (2007). https://doi.org/10.1007/s10014-007-0220-6

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