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Radiation-induced brain tumours after central nervous system irradiation in childhood: a review

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Abstract

Objects

Radiation-induced cerebral tumours constitute a significant risk for subjects undergoing radiotherapy for the management of cerebral neoplasms. Age-related cerebral vulnerability could be a specific factor in the genesis of these complications.

Methods

The pertinent literature of both paediatric and adult series has been reviewed. Three personal cases were added.

Results

One hundred forty-two paediatric second brain tumours were evaluated. Out of them, 69 were malignant gliomas, 33 meningiomas, 8 sarcomatous lesions and 13 low-grade astrocytomas. The average latency period for the appearance of the second tumour was 8 years. Among the second tumours occurring in adults, meningioma is the most common. In this subgroup, the latency period ranged between 16 and 30 years.

Conclusion

Paediatric radiation-induced brain tumours differ from the adult counterpart for both the histological subtypes. These figures indicate a specific vulnerability of the infantile brain demonstrated by the most frequent occurrence of highly malignant lesions.

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Acknowledgements

This study was financially supported by the Association “Ali di Scorta, per la lotta alle malformazioni e ai tumori cerebrali infantili”, www.alidiscorta.it.

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Authors and Affiliations

  1. Institute of Neurosurgery, Division of Paediatric Neurosurgery, Catholic University of Rome, Largo Agostino Gemelli, 8, 00168, Rome, Italy

    Benedetta Ludovica Pettorini, Massimo Caldarelli, Luca Massimi, Gianpiero Tamburrini & Concezio Di Rocco

  2. Department of Neurosurgery, Nara Medical University, Kashihara, Nara, Japan

    Young-Soo Park

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  1. Benedetta Ludovica Pettorini
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Correspondence to Benedetta Ludovica Pettorini.

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Pettorini, B.L., Park, YS., Caldarelli, M. et al. Radiation-induced brain tumours after central nervous system irradiation in childhood: a review. Childs Nerv Syst 24, 793–805 (2008). https://doi.org/10.1007/s00381-008-0631-7

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