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Synthesis, characterization, and preparation of nickel nanoparticles decorated electrochemically reduced graphene oxide modified electrode for electrochemical sensing of diclofenac

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Abstract

In this work, nickel nanoparticles (NiNPs) and graphene oxide (GO) were synthesized and characterized independently using spectroscopic and microscopic characterization techniques. Then, a new glassy carbon electrode modified with electrochemically reduced graphene oxide decorated with nickel nanoparticles (NiNPs/ERGO/GCE) was constructed by electrodeposition. The novel platform, NiNPs/ERGO/GCE, was characterized using scanning electron microscopy (SEM) and cyclic voltammetry (CV). SEM analysis clearly revealed efficient incorporation of NiNPs into the graphene sheets on the surface of the electrode. The prepared platform was used for the determination of diclofenac (DIC). A significant enhancement in the peak current response for DIC was observed at the composite modified electrode compared to the unmodified electrode. The NiNPs/ERGO composite modified electrode demonstrated excellent square wave voltammetric response towards the determination of DIC in the working range of 0.250–125 μM. The limit of detection (LOD) and limit of quantification (LOQ) of the proposed method were found to be 0.09 and 0.30 μM, respectively. The sensor was validated successfully for real sample analysis in pharmaceutical formulation and human urine samples with good recovery results. The proposed sensor also displayed good repeatability, reproducibility, long-term stability, and selectivity towards potential interferents. Hence, it is a promising material for electrochemical sensing of diclofenac and other similar drugs and biologically active compounds in real samples.

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Acknowledgments

The authors gratefully acknowledge the University of the Western Cape, Department of Chemistry, for supporting this work.

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Authors and Affiliations

  1. Department of Chemistry, College of Natural Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia

    Birhanu Mekassa, Bhagwan Singh Chandravanshi & Merid Tessema

  2. Department of Chemistry, University of the Western Cape, Private Bag X17, Robert Sobukwe Drive, Bellville, 7535, South Africa

    Priscilla G. L. Baker

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  1. Birhanu Mekassa
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  2. Priscilla G. L. Baker
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  3. Bhagwan Singh Chandravanshi
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  4. Merid Tessema
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Correspondence to Bhagwan Singh Chandravanshi.

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Mekassa, B., Baker, P.G.L., Chandravanshi, B.S. et al. Synthesis, characterization, and preparation of nickel nanoparticles decorated electrochemically reduced graphene oxide modified electrode for electrochemical sensing of diclofenac. J Solid State Electrochem 22, 3607–3619 (2018). https://doi.org/10.1007/s10008-018-4071-3

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