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Simultaneous determination of diclofenac and indomethacin using a sensitive electrochemical sensor based on multiwalled carbon nanotube and ionic liquid nanocomposite

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Abstract

Multiwalled carbon nanotube and ionic liquid-modified carbon ceramic electrode (MWCNT–IL|CCE) was employed for the simultaneous determination of diclofenac and indomethacin (IND). The measurements were carried out by differential pulse voltammetry method in optimal conditions. The prepared electrode showed appropriate voltammetric responses to DCF and IND with 0.225 V difference in the oxidation peak potentials, making fabricated electrode suitable for simultaneous determination of these compounds. The calibration curves were linear over a wide range of concentrations of each species including 0.05–50 μmol L−1 for DCF and 1–50 μmol L−1 for IND. Detection limits were found to be 18 and 260 nM for DCF and IND, respectively. The developed method having good stability and sensitivity was successfully applied for DCF and IND in commercial tablet as well as human blood plasma samples.

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Acknowledgments

The authors gratefully acknowledge the Research Council of Islamic Azad University, Ahar Branch, for financial support to carry out this research work.

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Authors and Affiliations

  1. Department of Chemistry, Ahar Branch, Islamic Azad University, 5451116714, Ahar, Iran

    Kianoush Sarhangzadeh, Ali Akbar Khatami, Mohammad Jabbari & Siavash Bahari

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  1. Kianoush Sarhangzadeh
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  2. Ali Akbar Khatami
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  3. Mohammad Jabbari
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  4. Siavash Bahari
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Correspondence to Kianoush Sarhangzadeh.

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Sarhangzadeh, K., Khatami, A.A., Jabbari, M. et al. Simultaneous determination of diclofenac and indomethacin using a sensitive electrochemical sensor based on multiwalled carbon nanotube and ionic liquid nanocomposite. J Appl Electrochem 43, 1217–1224 (2013). https://doi.org/10.1007/s10800-013-0609-3

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