Abstract
Purpose
The association between serum zinc level and overweight/obesity remains controversial. Hence, we performed a meta-analysis to summarize the relationships.
Methods
A systematic literature search was performed in PubMed, Web of Science and Embase for relevant English articles up to April 20, 2018. The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated with the random-effect model.
Results
For children and adults, the results showed that serum zinc level was significantly lower in the cases compared to controls ([SMD (95% CI): − 1.13 (− 2.03, − 0.23), Z = 2.45, P for Z = 0.014; I2 = 97.1%, P for I2 < 0.001] and [SMD (95% CI): − 0.41 (− 0.68, − 0.15), Z = 3.03, P for Z = 0.002; I2 = 62.9%, P for I2 = 0.009], respectively). The difference of serum zinc level between overweight adults and controls was not statistically significant [SMD (95% CI): − 0.09 (− 0.27, 0.09), Z = 0.97, P for Z = 0.334; I2 = 0.0%, P for I2 = 0.411]. In subgroup analyses, a lower serum zinc level in obese children compared with non-obese controls was observed [SMD (95% CI): − 2.14 (− 3.20, − 1.09)], and the SMD differ significantly between obese adults and controls in the case–control studies [SMD (95% CI): − 0.49 (− 0.90, − 0.08)].
Conclusion
Our meta-analysis suggested that the serum zinc level was significantly lower in obese children and adults. More large observational studies are required to confirm these results in future research.
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Acknowledgements
This work was supported by the Provincial Natural Science Foundation of the Province of Shandong (< Grant number ZR2015HM029> [to < XJ >]).
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Gu, K., Xiang, W., Zhang, Y. et al. The association between serum zinc level and overweight/obesity: a meta-analysis. Eur J Nutr 58, 2971–2982 (2019). https://doi.org/10.1007/s00394-018-1876-x
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DOI: https://doi.org/10.1007/s00394-018-1876-x