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Arterial and Atherosclerotic Plaque Biomechanics with Application to Stent Angioplasty Modeling

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Biomechanics: Trends in Modeling and Simulation

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 20))

Abstract

This chapter provides a brief review of continuum mechanics in relation to application in vascular biomechanics. The initial focus is on arterial tissue, where fundamental constitutive representations, tissue anisotropy, tissue remodeling and damage modeling are overviewed. The focus then shifts to diseased tissue (atherosclerotic plaque tissue), where experimental mechanical characterization, and constitutive and damage modeling are reviewed. Conclusions are drawn on what has been achieved thus far, and the main challenges for the future in characterizing and modeling this complex tissue are identified. Finally, the application of the arterial mechanics in the computational modeling of the stent angioplasty procedure is considered, with future challenges identified.

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Acknowledgments

The authors acknowledge funding from the Irish Research Council (IRC) under the Embark Initiative (C. Conway), the NUI Galway College of Engineering and Informatics (B. O’Reilly), the SFI/HEA Irish Centre for High-End Computing (ICHEC) and the Programme for Research in Third-Level Institutions (PRTLI) Cycle 5 and co-funded under the European Regional Development Fund (ERDF).

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Authors and Affiliations

  1. National University of Ireland, Galway, Ireland

    Brían L. O’Reilly, Claire Conway, J. Patrick McGarry & Peter E. McHugh

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  1. Brían L. O’Reilly
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  2. Claire Conway
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  3. J. Patrick McGarry
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  4. Peter E. McHugh
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Correspondence to Peter E. McHugh .

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  1. Institute of Biomechanics, Graz University of Technology, Graz, Austria

    Gerhard A. Holzapfel

  2. School of Mathematics and Statistics, University of Glasgow, Glasgow, United Kingdom

    Ray W. Ogden

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O’Reilly, B.L., Conway, C., McGarry, J.P., McHugh, P.E. (2017). Arterial and Atherosclerotic Plaque Biomechanics with Application to Stent Angioplasty Modeling. In: Holzapfel, G., Ogden, R. (eds) Biomechanics: Trends in Modeling and Simulation. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 20. Springer, Cham. https://doi.org/10.1007/978-3-319-41475-1_5

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  • DOI: https://doi.org/10.1007/978-3-319-41475-1_5

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