Abstract
One of the major failure modes of bioprosthetic heart valves is non-calcific structural deterioration due to fatigue of the tissue leaflets. Experimental methods to characterize tissue fatigue properties are complex and time-consuming. A constitutive fatigue model that could be calibrated by isolated material tests would be ideal for investigating the effects of more complex loading conditions. However, there is a lack of tissue fatigue damage models in the literature. To address these limitations, in this study, a phenomenological constitutive model was developed to describe the stress softening and permanent set effects of tissue subjected to long-term cyclic loading. The model was used to capture characteristic uniaxial fatigue data for glutaraldehyde-treated bovine pericardium and was then implemented into finite element software. The simulated fatigue response agreed well with the experimental data and thus demonstrates feasibility of this approach.
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Martin, C., Sun, W. Modeling of long-term fatigue damage of soft tissue with stress softening and permanent set effects. Biomech Model Mechanobiol 12, 645–655 (2013). https://doi.org/10.1007/s10237-012-0431-6
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DOI: https://doi.org/10.1007/s10237-012-0431-6