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Local Excision: Transanal Endoscopic Microsurgery and Transanal Minimally Invasive Surgery

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Rectal Cancer

Abstract

Transanal endoscopic microsurgery (TEM) and transanal minimally invasive surgery (TAMIS) are minimally invasive approaches developed to facilitate the local excision of rectal lesions, collectively known as transanal endoscopic surgery (TES). TEM was originally designed to perform submucosal or full-thickness local resection of rectal adenomas, but its application has since expanded to include the curative resection of carefully selected early-stage rectal cancer. In this chapter, current indications and contraindications for TES in the treatment of rectal cancer will be reviewed, in addition to patient selection, preoperative preparation, and perioperative considerations. Surgical techniques, tips and tricks, and pitfalls associated with TES will also be discussed, as well as the published outcomes of this approach with respect to morbidity, functional results, and short- and long-term oncologic outcomes relative to conventional radical resection with total mesorectal excision (TME). Finally, current obstacles to routine use and wider adoption of TES in the management of carefully selected rectal cancer cases will be addressed, including the challenges of procedural costs and training.

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References

  1. Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery – the clue to pelvic recurrence? Br J Surg. 1982;69:613–6.

    Article  CAS  PubMed  Google Scholar 

  2. Ridgway PF, Darzi AW. The role of total mesorectal excision in the management of rectal cancer. Cancer Control. 2003;10:205–11.

    Article  PubMed  Google Scholar 

  3. MacFarlane JK, Ryall RD, Heald RJ. Mesorectal excision for rectal cancer. Lancet. 1993;341:457–60.

    Article  CAS  PubMed  Google Scholar 

  4. Marijnen CAM, Kapiteijn E, van de Velde CJH, Martijn H, Steup WH, Wiggers T, et al. Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol. 2002;20:817–25.

    Article  CAS  PubMed  Google Scholar 

  5. Snijders HS, Wouters MWJM, van Leersum NJ, Kolfschoten NE, Henneman D, de Vries AC, et al. Meta-analysis of the risk for anastomotic leakage, the postoperative mortality caused by leakage in relation to the overall postoperative mortality. Eur J Surg Oncol. 2012;38:1013–9.

    Article  CAS  PubMed  Google Scholar 

  6. Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AMH, et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet. 2005;365:1718–26.

    Article  PubMed  Google Scholar 

  7. Kang S-B, Park JW, Jeong S-Y, Nam BH, Choi HS, Kim D-W, et al. Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial. Lancet Oncol. 2010;11:637–45.

    Article  PubMed  Google Scholar 

  8. van der Pas MH, Haglind E, Cuesta MA, Fürst A, Lacy AM, Hop WC, et al. Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol. 2013;14:210–8.

    Article  PubMed  Google Scholar 

  9. Stevenson ARL, Solomon MJ, Lumley JW, Hewett P, Clouston AD, Gebski VJ, et al. Effect of laparoscopic-assisted resection vs open resection on pathological outcomes in rectal cancer: the ALaCaRT randomized clinical trial. JAMA. 2015;314:1356–63.

    Article  CAS  PubMed  Google Scholar 

  10. Kulu Y, Müller-Stich BP, Bruckner T, Gehrig T, Büchler MW, Bergmann F, et al. Radical surgery with total mesorectal excision in patients with T1 rectal cancer. Ann Surg Oncol. 2015;22:2051–8.

    Article  PubMed  Google Scholar 

  11. Morris E, Quirke P, Thomas JD, Fairley L, Cottier B, Forman D. Unacceptable variation in abdominoperineal excision rates for rectal cancer: time to intervene? Gut. 2008;57:1690–7.

    Article  CAS  PubMed  Google Scholar 

  12. Bentrem DJ, Okabe S, Wong WD, Guillem JG, Weiser MR, Temple LK, et al. T1 adenocarcinoma of the rectum: transanal excision or radical surgery? Ann Surg. 2005;242:472–7. discussion 477–9

    PubMed  PubMed Central  Google Scholar 

  13. Moore JS, Cataldo PA, Osler T, Hyman NH. Transanal endoscopic microsurgery is more effective than traditional transanal excision for resection of rectal masses. Dis Colon Rectum. 2008;51:1026–30. discussion 1030–1

    Article  PubMed  Google Scholar 

  14. Langer C, Liersch T, Markus P, Süss M, Ghadimi M, Füzesi L, et al. Transanal endoscopic microsurgery (TEM) for minimally invasive resection of rectal adenomas and “Low-risk” carcinomas (uT1, G1–2). Z Gastroenterol. 2002;40:67–72.

    Article  CAS  PubMed  Google Scholar 

  15. Clancy C, Burke JP, Albert MR, O’Connell PR, Winter DC. Transanal endoscopic microsurgery versus standard transanal excision for the removal of rectal neoplasms: a systematic review and meta-analysis. Dis Colon Rectum. 2015;58:254–61.

    Article  PubMed  Google Scholar 

  16. Mellgren A, Sirivongs P, Rothenberger DA, Madoff RD, García-Aguilar J. Is local excision adequate therapy for early rectal cancer? Dis Colon Rectum. 2000;43:1064–71. discussion 1071–4

    Article  CAS  PubMed  Google Scholar 

  17. Paty PB, Nash GM, Baron P, Zakowski M, Minsky BD, Blumberg D, et al. Long-term results of local excision for rectal cancer. Ann Surg. 2002;236:522–9. discussion 529–30

    Article  PubMed  PubMed Central  Google Scholar 

  18. You YN, Baxter NN, Stewart A, Nelson H. Is the increasing rate of local excision for stage I rectal cancer in the United States justified? Ann Surg. 2007;245:726–33.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Buess G, Theiss R, Hutterer F, Pichlmaier H, Pelz C, Holfeld T, et al. Transanal endoscopic surgery of the rectum – testing a new method in animal experiments. Leber Magen Darm. 1983;13:73–7.

    CAS  PubMed  Google Scholar 

  20. Albert MR, Atallah SB, DeBeche-Adams TC, Izfar S, Larach SW. Transanal minimally invasive surgery (TAMIS) for local excision of benign neoplasms and early-stage rectal cancer: efficacy and outcomes in the first 50 patients. Dis Colon Rectum. 2013;56:301–7.

    Article  PubMed  Google Scholar 

  21. Atallah S, Albert M, Larach S. Transanal minimally invasive surgery: a giant leap forward. Surg Endosc. 2010;24:2200–5.

    Article  PubMed  Google Scholar 

  22. McLemore EC, Weston LA, Coker AM, Jacobsen GR, Talamini MA, Horgan S, et al. Transanal minimally invasive surgery for benign and malignant rectal neoplasia. Am J Surg. 2014;208:372–81.

    Article  PubMed  Google Scholar 

  23. Christoforidis D, Cho H-M, Dixon MR, Mellgren AF, Madoff RD, Finne CO. Transanal endoscopic microsurgery versus conventional transanal excision for patients with early rectal cancer. Ann Surg. 2009;249:776–82.

    Article  PubMed  Google Scholar 

  24. Heidary B, Phang TP, Raval MJ, Brown CJ. Transanal endoscopic microsurgery: a review. Can J Surg. 2014;57:127–38.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Morino M, Arezzo A, Allaix ME. Transanal endoscopic microsurgery. Tech Coloproctol. 2013;17(Suppl 1):S55–61.

    Article  PubMed  Google Scholar 

  26. Serra-Aracil X, Mora-Lopez L, Alcantara-Moral M, Caro-Tarrago A, Gomez-Diaz CJ, Navarro-Soto S. Transanal endoscopic surgery in rectal cancer. World J Gastroenterol. 2014;20:11538–45.

    Article  PubMed  PubMed Central  Google Scholar 

  27. You YN. Local excision: is it an adequate substitute for radical resection in T1/T2 patients? Semin Radiat Oncol. 2011;21:178–84.

    Article  PubMed  Google Scholar 

  28. Guerrieri M, Gesuita R, Ghiselli R, Lezoche G, Budassi A, Baldarelli M. Treatment of rectal cancer by transanal endoscopic microsurgery: experience with 425 patients. World J Gastroenterol. 2014;20:9556–63.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Garcia-Aguilar J, Shi Q, Thomas CR, Chan E, Cataldo P, Marcet J, et al. A phase II trial of neoadjuvant chemoradiation and local excision for T2N0 rectal cancer: preliminary results of the ACOSOG Z6041 trial. Ann Surg Oncol. 2012;19:384–91.

    Article  PubMed  Google Scholar 

  30. Lezoche E, Baldarelli M, Lezoche G, Paganini AM, Gesuita R, Guerrieri M. Randomized clinical trial of endoluminal locoregional resection versus laparoscopic total mesorectal excision for T2 rectal cancer after neoadjuvant therapy. Br J Surg. 2012;99:1211–8.

    Article  CAS  PubMed  Google Scholar 

  31. Barendse RM, van den Broek FJC, Dekker E, Bemelman WA, de Graaf EJR, Fockens P, et al. Systematic review of endoscopic mucosal resection versus transanal endoscopic microsurgery for large rectal adenomas. Endoscopy. 2011;43:941–9.

    Article  CAS  PubMed  Google Scholar 

  32. van den Broek FJC, de Graaf EJR, Dijkgraaf MGW, Reitsma JB, Haringsma J, Timmer R, et al. Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study). BMC Surg. 2009;9:4.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Arolfo S, Allaix ME, Migliore M, Cravero F, Arezzo A, Morino M. Transanal endoscopic microsurgery after endoscopic resection of malignant rectal polyps: a useful technique for indication to radical treatment. Surg Endosc. 2014;28:1136–40.

    Article  PubMed  Google Scholar 

  34. Serra-Aracil X, Mora-Lopez L, Alcantara-Moral M, Corredera-Cantarin C, Gomez-Diaz C, Navarro-Soto S. Atypical indications for transanal endoscopic microsurgery to avoid major surgery. Tech Coloproctol. 2014;18:157–64.

    Article  CAS  PubMed  Google Scholar 

  35. Whitehouse PA, Armitage JN, Tilney HS, Simson JNL. Transanal endoscopic microsurgery: local recurrence rate following resection of rectal cancer. Color Dis. 2008;10:187–93.

    CAS  Google Scholar 

  36. Kikuchi R, Takano M, Takagi K, Fujimoto N, Nozaki R, Fujiyoshi T, et al. Management of early invasive colorectal cancer. Risk of recurrence and clinical guidelines. Dis Colon Rectum. 1995;38:1286–95.

    Article  CAS  PubMed  Google Scholar 

  37. Bach SP, Hill J, Monson JRT, Simson JNL, Lane L, Merrie A, et al. A predictive model for local recurrence after transanal endoscopic microsurgery for rectal cancer. Br J Surg. 2009;96:280–90.

    Article  CAS  PubMed  Google Scholar 

  38. Sengupta S, Tjandra JJ. Local excision of rectal cancer: what is the evidence? Dis Colon Rectum. 2001;44:1345–61.

    Article  CAS  PubMed  Google Scholar 

  39. Suzuki A, Togashi K, Nokubi M, Koinuma K, Miyakura Y, Horie H, et al. Evaluation of venous invasion by elastica van gieson stain and tumor budding predicts local and distant metastases in patients with T1 stage colorectal cancer. Am J Surg Pathol. 2009;33:1601–7.

    Article  PubMed  Google Scholar 

  40. Doornebosch PG, Zeestraten E, de Graaf EJR, Hermsen P, Dawson I, Tollenaar RAEM, et al. Transanal endoscopic microsurgery for T1 rectal cancer: size matters! Surg Endosc. 2012;26:551–7.

    Article  PubMed  Google Scholar 

  41. Shinto E, Jass JR, Tsuda H, Sato T, Ueno H, Hase K, et al. Differential prognostic significance of morphologic invasive markers in colorectal cancer: tumor budding and cytoplasmic podia. Dis Colon Rectum. 2006;49:1422–30.

    Article  PubMed  Google Scholar 

  42. Syk E, Lenander C, Nilsson PJ, Rubio CA, Glimelius B. Tumour budding correlates with local recurrence of rectal cancer. Color Dis. 2011;13:255–62.

    Article  CAS  Google Scholar 

  43. Ueno H, Price AB, Wilkinson KH, Jass JR, Mochizuki H, Talbot IC. A new prognostic staging system for rectal cancer. Ann Surg. 2004;240:832–9.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Ueno H, Mochizuki H, Hashiguchi Y, Shimazaki H, Aida S, Hase K, et al. Risk factors for an adverse outcome in early invasive colorectal carcinoma. Gastroenterology. 2004;127:385–94.

    Article  PubMed  Google Scholar 

  45. Mitrovic B, Schaeffer DF, Riddell RH, Kirsch R. Tumor budding in colorectal carcinoma: time to take notice. Mod Pathol. 2012;25:1315–25.

    Article  CAS  PubMed  Google Scholar 

  46. Benson AB, Venook AP, Bekaii-Saab T, Chan E, Chen Y-J, Cooper HS, et al. Rectal cancer, version 2.2015. J Natl Compr Canc Netw. 2015;13:719–28. quiz 728

    Article  PubMed  Google Scholar 

  47. Nielsen LBJ, Wille-Jørgensen P. National and international guidelines for rectal cancer. Color Dis. 2014;16:854–65.

    Article  CAS  Google Scholar 

  48. Park SU, Min YW, Shin JU, Choi JH, Kim Y-H, Kim JJ, et al. Endoscopic submucosal dissection or transanal endoscopic microsurgery for nonpolypoid rectal high grade dysplasia and submucosa-invading rectal cancer. Endoscopy. 2012;44:1031–6.

    Article  CAS  PubMed  Google Scholar 

  49. Kawaguti FS, Nahas CSR, Marques CFS, Martins BC, Retes FA, Medeiros RS, et al. Endoscopic submucosal dissection versus transanal endoscopic microsurgery for the treatment of early rectal cancer. Surg Endoscopy. 2014;28:1173–9.

    Article  Google Scholar 

  50. Morino M, Risio M, Bach S, Beets-Tan R, Bujko K, Panis Y, et al. Early rectal cancer: the European Association for Endoscopic Surgery (EAES) clinical consensus conference. Surg Endosc. 2015;29:755–73.

    Article  PubMed  Google Scholar 

  51. Lee W, Lee D, Choi S, Chun H. Transanal endoscopic microsurgery and radical surgery for T1 and T2 rectal cancer. Surg Endosc. 2003;17:1283–7.

    Article  CAS  PubMed  Google Scholar 

  52. Borschitz T, Wachtlin D, Möhler M, Schmidberger H, Junginger T. Neoadjuvant chemoradiation and local excision for T2-3 rectal cancer. Ann Surg Oncol. 2008;15:712–20.

    Article  PubMed  Google Scholar 

  53. Tsai BM, Finne CO, Nordenstam JF, Christoforidis D, Madoff RD, Mellgren A. Transanal endoscopic microsurgery resection of rectal tumors: outcomes and recommendations. Dis Colon Rectum. 2010;53:16–23.

    Article  PubMed  Google Scholar 

  54. Perez RO, Habr-Gama A, São Julião GP, Proscurshim I, Scanavini Neto A, Gama-Rodrigues J. Transanal endoscopic microsurgery for residual rectal cancer after neoadjuvant chemoradiation therapy is associated with significant immediate pain and hospital readmission rates. Dis Colon Rectum. 2011;54:545–51.

    Article  PubMed  Google Scholar 

  55. Habr-Gama A, Sabbaga J, Gama-Rodrigues J, São Julião GP, Proscurshim I, Bailão Aguilar P, et al. Watch and wait approach following extended neoadjuvant chemoradiation for distal rectal cancer: are we getting closer to anal cancer management? Dis Colon Rectum. 2013;56:1109–17.

    Article  PubMed  Google Scholar 

  56. Maas M, Beets-Tan RGH, Lambregts DMJ, Lammering G, Nelemans PJ, Engelen SME, et al. Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J Clin Oncol. 2011;29:4633–40.

    Article  PubMed  Google Scholar 

  57. Dalton RSJ, Velineni R, Osborne ME, Thomas R, Harries S, Gee AS, et al. A single-centre experience of chemoradiotherapy for rectal cancer: is there potential for nonoperative management? Color Dis. 2012;14:567–71.

    Article  CAS  Google Scholar 

  58. Ganai S, Garb JL, Kanumuri P, Rao RS, Alexander AI, Wait RB. Mapping the rectum: spatial analysis of transanal endoscopic microsurgical outcomes using GIS technology. J Gastrointest Surg. 2006;10:22–31.

    Article  PubMed  Google Scholar 

  59. Lev-Chelouche D, Margel D, Goldman G, Rabau MJ. Transanal endoscopic microsurgery: experience with 75 rectal neoplasms. Dis Colon Rectum. 2000;43:662–7. discussion 667–8

    Article  CAS  PubMed  Google Scholar 

  60. Demartines N, von Flüe MO, Harder FH. Transanal endoscopic microsurgical excision of rectal tumors: indications and results. World J Surg. 2001;25:870–5.

    Article  CAS  PubMed  Google Scholar 

  61. Baatrup G, Borschitz T, Cunningham C, Qvist N. Perforation into the peritoneal cavity during transanal endoscopic microsurgery for rectal cancer is not associated with major complications or oncological compromise. Surg Endosc. 2009;23:2680–3.

    Article  PubMed  Google Scholar 

  62. Gavagan JA, Whiteford MH, Swanstrom LL. Full-thickness intraperitoneal excision by transanal endoscopic microsurgery does not increase short-term complications. Am J Surg. 2004;187:630–4.

    Article  PubMed  Google Scholar 

  63. Marks JH, Frenkel JL, Greenleaf CE, D’Andrea AP. Transanal endoscopic microsurgery with entrance into the peritoneal cavity: is it safe? Dis Colon Rectum. 2014;57:1176–82.

    Article  PubMed  Google Scholar 

  64. Ramwell A, Evans J, Bignell M, Mathias J, Simson J. The creation of a peritoneal defect in transanal endoscopic microsurgery does not increase complications. Color Dis. 2009;11:964–6.

    Article  CAS  Google Scholar 

  65. Morino M, Allaix ME, Famiglietti F, Caldart M, Arezzo A. Does peritoneal perforation affect short- and long-term outcomes after transanal endoscopic microsurgery? Surg Endosc. 2013;27:181–8.

    Article  PubMed  Google Scholar 

  66. Baatrup G, Endreseth BH, Isaksen V, Kjellmo A, Tveit KM, Nesbakken A. Preoperative staging and treatment options in T1 rectal adenocarcinoma. Acta Oncol. 2009;48:328–42.

    Article  PubMed  Google Scholar 

  67. Molina G, Bordeianou L, Shellito P, Sylla P. Transanal endoscopic resection with peritoneal entry: a word of caution. Surg Endosc. 2016;30:1816–25.

    Article  PubMed  Google Scholar 

  68. Hahnloser D, Cantero R, Salgado G, Dindo D, Rega D, Delrio P. Transanal minimal invasive surgery for rectal lesions: should the defect be closed? Color Dis. 2015;17:397–402.

    Article  CAS  Google Scholar 

  69. Lee T-G, Lee S-J. Transanal single-port microsurgery for rectal tumors: minimal invasive surgery under spinal anesthesia. Surg Endosc. 2014;28:271–80.

    Article  PubMed  Google Scholar 

  70. Hahnloser D, Wolff BG, Larson DW, Ping J, Nivatvongs S. Immediate radical resection after local excision of rectal cancer: an oncologic compromise? Dis Colon Rectum. 2005;48:429–37.

    Article  PubMed  Google Scholar 

  71. Ashraf S, Hompes R, Slater A, Lindsey I, Bach S, Mortensen NJ, et al. A critical appraisal of endorectal ultrasound and transanal endoscopic microsurgery and decision-making in early rectal cancer. Color Dis. 2012;14:821–6.

    Article  CAS  Google Scholar 

  72. Starck M, Bohe M, Simanaitis M, Valentin L. Rectal endosonography can distinguish benign rectal lesions from invasive early rectal cancers. Color Dis. 2003;5:246–50.

    Article  CAS  Google Scholar 

  73. Mondal D, Betts M, Cunningham C, Mortensen NJ, Lindsey I, Slater A. How useful is endorectal ultrasound in the management of early rectal carcinoma? Int J Color Dis. 2014;29:1101–4.

    Article  CAS  Google Scholar 

  74. Bipat S, Glas AS, Slors FJM, Zwinderman AH, Bossuyt PMM, Stoker J. Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging – a meta-analysis. Radiology. 2004;232:773–83.

    Article  PubMed  Google Scholar 

  75. Kim CK, Kim SH, Chun HK, Lee W-Y, Yun S-H, Song S-Y, et al. Preoperative staging of rectal cancer: accuracy of 3-Tesla magnetic resonance imaging. Eur Radiol. 2006;16:972–80.

    Article  PubMed  Google Scholar 

  76. Kunitake H, Abbas MA. Transanal endoscopic microsurgery for rectal tumors: a review. Perm J. 2012;16:45–50.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Lirici MM, Di Paola M, Ponzano C, Hüscher CGS. Combining ultrasonic dissection and the Storz operation rectoscope. Surg Endosc. 2003;17:1292–7.

    Article  CAS  PubMed  Google Scholar 

  78. Hompes R, Ris F, Cunningham C, Mortensen NJ, Cahill RA. Transanal glove port is a safe and cost-effective alternative for transanal endoscopic microsurgery. Br J Surg. 2012;99:1429–35.

    Article  CAS  PubMed  Google Scholar 

  79. McLemore EC, Coker A, Jacobsen G, Talamini MA, Horgan S. eTAMIS: endoscopic visualization for transanal minimally invasive surgery. Surg Endosc. 2013;27:1842–5.

    Article  PubMed  Google Scholar 

  80. Bislenghi G, Wolthuis AM, de Buck van Overstraeten A, D’Hoore A. AirSeal system insufflator to maintain a stable pneumorectum during TAMIS. Tech Coloproctol. 2015;19:43–5.

    Article  CAS  PubMed  Google Scholar 

  81. Atallah S, Parra-Davila E, DeBeche-Adams T, Albert M, Larach S. Excision of a rectal neoplasm using robotic transanal surgery (RTS): a description of the technique. Tech Coloproctology. 2012;16:389–92.

    Article  CAS  Google Scholar 

  82. Buchs NC, Pugin F, Volonte F, Hagen ME, Morel P, Ris F. Robotic transanal endoscopic microsurgery: technical details for the lateral approach. Dis Colon Rectum. 2013;56:1194–8.

    Article  PubMed  Google Scholar 

  83. Hompes R, Rauh SM, Ris F, Tuynman JB, Mortensen NJ. Robotic transanal minimally invasive surgery for local excision of rectal neoplasms. Br J Surg. 2014;101:578–81.

    Article  CAS  PubMed  Google Scholar 

  84. Hayashi S, Takayama T, Yamagata M, Matsuda M, Masuda H. Single-incision laparoscopic surgery used to perform transanal endoscopic microsurgery (SILSTEM) for T1 rectal cancer under spinal anesthesia: report of a case. Surg Today. 2013;43:325–8.

    Article  PubMed  Google Scholar 

  85. Allaix ME, Arezzo A, Arolfo S, Caldart M, Rebecchi F, Morino M. Transanal endoscopic microsurgery for rectal neoplasms. How I do it. J Gastrointest Surg. 2013;17:586–92.

    Article  PubMed  Google Scholar 

  86. Guerrieri M, Baldarelli M, Organetti L, Grillo Ruggeri F, Mantello G, Bartolacci S, et al. Transanal endoscopic microsurgery for the treatment of selected patients with distal rectal cancer: 15 years experience. Surg Endosc. 2008;22:2030–5.

    Article  CAS  PubMed  Google Scholar 

  87. Paganini AM, Balla A, Quaresima S, D’Ambrosio G, Bruzzone P, Lezoche E. Tricks to decrease the suture line dehiscence rate during endoluminal loco-regional resection (ELRR) by transanal endoscopic microsurgery (TEM). Surg Endosc. 2015;29:1045–50.

    Article  PubMed  Google Scholar 

  88. Bignell MB, Ramwell A, Evans JR, Dastur N, Simson JNL. Complications of transanal endoscopic microsurgery (TEMS): a prospective audit. Color Dis. 2010;12:e99–103.

    CAS  Google Scholar 

  89. Allaix ME, Arezzo A, Caldart M, Festa F, Morino M. Transanal endoscopic microsurgery for rectal neoplasms: experience of 300 consecutive cases. Dis Colon Rectum. 2009;52:1831–6.

    Article  PubMed  Google Scholar 

  90. Barendse RM, Dijkgraaf MG, Rolf UR, Bijnen AB, Consten ECJ, Hoff C, et al. Colorectal surgeons’ learning curve of transanal endoscopic microsurgery. Surg Endosc. 2013;27:3591–602.

    Article  PubMed  Google Scholar 

  91. Ramirez JM, Aguilella V, Arribas D, Martinez M. Transanal full-thickness excision of rectal tumours: should the defect be sutured? A randomized controlled trial. Color Dis. 2002;4:51–5.

    Article  Google Scholar 

  92. Khoury W, Igov I, Issa N, Gimelfarb Y, Duek SD. Transanal endoscopic microsurgery for upper rectal tumors. Surg Endosc. 2014;28:2066–71.

    Article  PubMed  Google Scholar 

  93. Ford SJ, Wheeler JMD, Borley NR. Factors influencing selection for a day-case or 23-h stay procedure in transanal endoscopic microsurgery. Br J Surg. 2010;97:410–4.

    Article  CAS  PubMed  Google Scholar 

  94. Benson AB, Bekaii-Saab T, Chan E, Chen Y-J, Choti MA, Cooper HS, et al. Rectal cancer. J Natl Compr Cancer Netw. 2012;10:1528–64.

    Article  CAS  Google Scholar 

  95. Ramirez JM, Aguilella V, Valencia J, Ortego J, Gracia JA, Escudero P, et al. Transanal endoscopic microsurgery for rectal cancer. Long-term oncologic results. Int J Color Dis. 2011;26:437–43.

    Article  Google Scholar 

  96. Lezoche G, Guerrieri M, Baldarelli M, Paganini AM, D’Ambrosio G, Campagnacci R, et al. Transanal endoscopic microsurgery for 135 patients with small nonadvanced low rectal cancer (iT1-iT2, iN0): short- and long-term results. Surg Endosc. 2011;25:1222–9.

    Article  PubMed  Google Scholar 

  97. Nieuwenhuis DH, Draaisma WA, Verberne GHM, van Overbeeke AJ, Consten ECJ. Transanal endoscopic operation for rectal lesions using two-dimensional visualization and standard endoscopic instruments: a prospective cohort study and comparison with the literature. Surg Endosc. 2009;23:80–6.

    Article  CAS  PubMed  Google Scholar 

  98. Serra-Aracil X, Mora-Lopez L, Alcantara-Moral M, Caro-Tarrago A, Navarro-Soto S. Transanal endoscopic microsurgery with 3-D (TEM) or high-definition 2-D transanal endoscopic operation (TEO) for rectal tumors. A prospective, randomized clinical trial. Int J Color Dis. 2014;29:605–10.

    Article  Google Scholar 

  99. Bretagnol F, Merrie A, George B, Warren BF, Mortensen NJ. Local excision of rectal tumours by transanal endoscopic microsurgery. Br J Surg. 2007;94:627–33.

    Article  CAS  PubMed  Google Scholar 

  100. Barendse RM, Doornebosch PG, Bemelman WA, Fockens P, Dekker E, de Graaf EJR. Transanal employment of single access ports is feasible for rectal surgery. Ann Surg. 2012;256:1030–3.

    Article  PubMed  Google Scholar 

  101. De Graaf EJR, Doornebosch PG, Tollenaar RAEM, Meershoek-Klein Kranenbarg E, de Boer AC, Bekkering FC, et al. Transanal endoscopic microsurgery versus total mesorectal excision of T1 rectal adenocarcinomas with curative intention. Eur J Surg Oncol. 2009;35:1280–5.

    Article  PubMed  Google Scholar 

  102. Heintz A, Mörschel M, Junginger T. Comparison of results after transanal endoscopic microsurgery and radical resection for T1 carcinoma of the rectum. Surg Endosc. 1998;12:1145–8.

    Article  CAS  PubMed  Google Scholar 

  103. Palma P, Horisberger K, Joos A, Rothenhoefer S, Willeke F, Post S. Local excision of early rectal cancer: is transanal endoscopic microsurgery an alternative to radical surgery? Rev esp Enferm dig. 2009;101:172–8.

    Article  CAS  PubMed  Google Scholar 

  104. Suppiah A, Maslekar S, Alabi A, Hartley JE, Monson JRT. Transanal endoscopic microsurgery in early rectal cancer: time for a trial? Color Dis. 2008;10:314–27. discussion 327–9

    Article  CAS  Google Scholar 

  105. Kumar AS, Coralic J, Kelleher DC, Sidani S, Kolli K, Smith LE. Complications of transanal endoscopic microsurgery are rare and minor: a single institution’s analysis and comparison to existing data. Dis Colon Rectum. 2013;56:295–300.

    Article  PubMed  Google Scholar 

  106. Dias AR, Nahas CSR, Marques CFS, Nahas SC, Cecconello I. Transanal endoscopic microsurgery: indications, results and controversies. Tech Coloproctol. 2009;13:105–11.

    Article  PubMed  Google Scholar 

  107. Guerrieri M, Baldarelli M, de Sanctis A, Campagnacci R, Rimini M, Lezoche E. Treatment of rectal adenomas by transanal endoscopic microsurgery: 15 years’ experience. Surg Endosc. 2010;24:445–9.

    Article  PubMed  Google Scholar 

  108. Martin-Perez B, Andrade-Ribeiro GD, Hunter L, Atallah S. A systematic review of transanal minimally invasive surgery (TAMIS) from 2010 to 2013. Tech Coloproctol. 2014;18:775–88.

    Article  CAS  PubMed  Google Scholar 

  109. Allaix ME, Rebecchi F, Giaccone C, Mistrangelo M, Morino M. Long-term functional results and quality of life after transanal endoscopic microsurgery. Br J Surg. 2011;98:1635–43.

    Article  CAS  PubMed  Google Scholar 

  110. Kennedy ML, Lubowski DZ, King DW. Transanal endoscopic microsurgery excision: is anorectal function compromised? Dis Colon Rectum. 2002;45:601–4.

    Article  CAS  PubMed  Google Scholar 

  111. Kreis ME, Jehle EC, Ohlemann M, Becker HD, Starlinger MJ. Functional results after transanal rectal advancement flap repair of trans-sphincteric fistula. Br J Surg. 1998;85:240–2.

    Article  CAS  PubMed  Google Scholar 

  112. Cataldo PA, O’Brien S, Osler T. Transanal endoscopic microsurgery: a prospective evaluation of functional results. Dis Colon Rectum. 2005;48:1366–71.

    Article  PubMed  Google Scholar 

  113. Hompes R, Ashraf SQ, Gosselink MP, van Dongen KW, Mortensen NJ, Lindsey I, et al. Evaluation of quality of life and function at 1 year after transanal endoscopic microsurgery. Color Dis. 2015;17:O54–61.

    Article  CAS  Google Scholar 

  114. Schiphorst AHW, Langenhoff BS, Maring J, Pronk A, Zimmerman DDE. Transanal minimally invasive surgery: initial experience and short-term functional results. Dis Colon Rectum. 2014;57:927–32.

    Article  PubMed  Google Scholar 

  115. Speake D, Lees N, McMahon RFT, Hill J. Who should be followed up after transanal endoscopic resection of rectal tumours? Color Dis. 2008;10:330–5.

    Article  CAS  Google Scholar 

  116. Doornebosch PG, Ferenschild FTJ, de Wilt JHW, Dawson I, Tetteroo GWM, de Graaf EJR. Treatment of recurrence after transanal endoscopic microsurgery (TEM) for T1 rectal cancer. Dis Colon Rectum. 2010;53:1234–9.

    Article  PubMed  Google Scholar 

  117. Stipa F, Giaccaglia V, Burza A. Management and outcome of local recurrence following transanal endoscopic microsurgery for rectal cancer. Dis Colon Rectum. 2012;55:262–9.

    Article  PubMed  Google Scholar 

  118. Mentges B, Buess G, Effinger G, Manncke K, Becker HD. Indications and results of local treatment of rectal cancer. Br J Surg. 1997;84:348–51.

    Article  CAS  PubMed  Google Scholar 

  119. Floyd ND, Saclarides TJ. Transanal endoscopic microsurgical resection of pT1 rectal tumors. Dis Colon Rectum. 2006;49:164–8.

    Article  PubMed  Google Scholar 

  120. Borschitz T, Heintz A, Junginger T. The influence of histopathologic criteria on the long-term prognosis of locally excised pT1 rectal carcinomas: results of local excision (transanal endoscopic microsurgery) and immediate reoperation. Dis Colon Rectum. 2006;49:1492–506. discussion 1500–5

    Article  PubMed  Google Scholar 

  121. Baatrup G, Breum B, Qvist N, Wille-Jørgensen P, Elbrønd H, Møller P, et al. Transanal endoscopic microsurgery in 143 consecutive patients with rectal adenocarcinoma: results from a danish multicenter study. Color Dis. 2009;11:270–5.

    Article  CAS  Google Scholar 

  122. Morino M, Allaix ME, Caldart M, Scozzari G, Arezzo A. Risk factors for recurrence after transanal endoscopic microsurgery for rectal malignant neoplasm. Surg Endosc. 2011;25:3683–90.

    Article  PubMed  Google Scholar 

  123. Amann M, Modabber A, Burghardt J, Stratz C, Falch C, Buess GF, et al. Transanal endoscopic microsurgery in treatment of rectal adenomas and T1 low-risk carcinomas. World J Surg Oncol. 2012;10:255.

    Article  PubMed  PubMed Central  Google Scholar 

  124. Winde G, Nottberg H, Keller R, Schmid KW, Bünte H. Surgical cure for early rectal carcinomas (T1). Transanal endoscopic microsurgery vs. anterior resection. Dis Colon Rectum. 1996;39:969–76.

    Article  CAS  PubMed  Google Scholar 

  125. Tytherleigh MG, Warren BF, Mortensen NJM. Management of early rectal cancer. Br J Surg. 2008;95:409–23.

    Article  CAS  PubMed  Google Scholar 

  126. van den Boezem PB, Kruyt PM, Stommel MWJ, Tobon Morales R, Cuesta MA, Sietses C. Transanal single-port surgery for the resection of large polyps. Dig Surg. 2011;28:412–6.

    Article  PubMed  Google Scholar 

  127. Lim S-B, Seo S-I, Lee JL, Kwak JY, Jang TY, Kim CW, et al. Feasibility of transanal minimally invasive surgery for mid-rectal lesions. Surg Endosc. 2012;26:3127–32.

    Article  PubMed  Google Scholar 

  128. Ragupathi M, Vande Maele D, Nieto J, Pickron TB, Haas EM. Transanal endoscopic video-assisted (TEVA) excision. Surg Endosc. 2012;26:3528–35.

    Article  PubMed  Google Scholar 

  129. Sevá-Pereira G, Trombeta VL, Capochim Romagnolo LG. Transanal minimally invasive surgery (TAMIS) using a new disposable device: our initial experience. Tech Coloproctol. 2014;18:393–7.

    Article  PubMed  Google Scholar 

  130. Bridoux V, Schwarz L, Suaud L, Dazza M, Michot F, Tuech J-J. Transanal minimal invasive surgery with the endorec(TM) trocar: a low cost but effective technique. Int J Color Dis. 2014;29:177–81.

    Article  Google Scholar 

  131. Gorgun IE, Gorgun IE, Aytac E, Costedio MM, Erem HH, Valente MA, et al. Transanal endoscopic surgery using a single access port: a practical tool in the surgeon’s toybox. Surg Endosc. 2014;28:1034–8.

    Article  CAS  PubMed  Google Scholar 

  132. Lorenz C, Nimmesgern T, Langwieler TE. Transanal endoscopic surgery using different single-port devices. Surg Technol Int. 2011;21:107–11.

    PubMed  Google Scholar 

  133. Duek SD, Issa N, Hershko DD, Krausz MM. Outcome of transanal endoscopic microsurgery and adjuvant radiotherapy in patients with T2 rectal cancer. Dis Colon Rectum. 2008;51:379–84. discussion 384

    Article  PubMed  Google Scholar 

  134. Lezoche E, Guerrieri M, Paganini AM, Feliciotti F. Transanal endoscopic microsurgical excision of irradiated and nonirradiated rectal cancer. A 5-year experience. Surg Laparosc Endosc. 1998;8:249–56.

    Article  CAS  PubMed  Google Scholar 

  135. Allaix ME, Arezzo A, Giraudo G, Morino M. Transanal endoscopic microsurgery vs. laparoscopic total mesorectal excision for T2N0 rectal cancer. J Gastrointest Surg. 2012;16:2280–7.

    Article  PubMed  Google Scholar 

  136. Lezoche G, Baldarelli M, Guerrieri M, Paganini AM, De Sanctis A, et al. A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy. Surg Endosc. 2008;22:352–8.

    Article  CAS  PubMed  Google Scholar 

  137. Hershman MJ, Myint AS, Makin CA. Multi-modality approach in curative local treatment of early rectal carcinomas. Color Dis. 2003;5:445–50.

    Article  CAS  Google Scholar 

  138. Kim CJ, Yeatman TJ, Coppola D, Trotti A, Williams B, Barthel JS, et al. Local excision of T2 and T3 rectal cancers after downstaging chemoradiation. Ann Surg. 2001;234:352–8. discussion 358–9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  139. Meadows K, Morris CG, Rout WR, Zlotecki RA, Hochwald SN, Marsh RD, et al. Preoperative radiotherapy alone or combined with chemotherapy followed by transanal excision for rectal adenocarcinoma. Am J Clin Oncol. 2006;29:430–4.

    Article  PubMed  Google Scholar 

  140. Nair RM, Siegel EM, Chen D-T, Fulp WJ, Yeatman TJ, Malafa MP, et al. Long-term results of transanal excision after neoadjuvant chemoradiation for T2 and T3 adenocarcinomas of the rectum. J Gastrointest Surg. 2008;12:1797–805. discussion 1805–6

    Article  PubMed  Google Scholar 

  141. Ruo L, Guillem JG, Minsky BD, Quan SHQ, Paty PB, Cohen AM. Preoperative radiation with or without chemotherapy and full-thickness transanal excision for selected T2 and T3 distal rectal cancers. Int J Color Dis. 2002;17:54–8.

    Article  CAS  Google Scholar 

  142. Garcia-Aguilar J, Renfro LA, Chow OS, Shi Q, Carrero XW, Lynn PB, et al. Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial. Lancet Oncol. 2015;16:1537–46.

    Article  PubMed  PubMed Central  Google Scholar 

  143. Levic K, Bulut O, Hesselfeldt P, Bülow S. The outcome of rectal cancer after early salvage surgery following transanal endoscopic microsurgery seems promising. Dan Med J. 2012;59:A4507.

    PubMed  Google Scholar 

  144. Doornebosch PG, Tollenaar RAEM, De Graaf EJR. Is the increasing role of transanal endoscopic microsurgery in curation for T1 rectal cancer justified? A systematic review. Acta Oncol. 2009;48:343–53.

    Article  PubMed  Google Scholar 

  145. Weiser MR, Landmann RG, Wong WD, Shia J, Guillem JG, Temple LK, et al. Surgical salvage of recurrent rectal cancer after transanal excision. Dis Colon Rectum. 2005;48:1169–75.

    Article  PubMed  Google Scholar 

  146. Baron PL, Enker WE, Zakowski MF, Urmacher C. Immediate vs. salvage resection after local treatment for early rectal cancer. Dis Colon Rectum. 1995;38:177–81.

    Article  CAS  PubMed  Google Scholar 

  147. Koebrugge B, Bosscha K, Ernst MF. Transanal endoscopic microsurgery for local excision of rectal lesions: is there a learning curve? Dig Surg. 2009;26:372–7.

    Article  CAS  PubMed  Google Scholar 

  148. Cocilovo C, Smith LE, Stahl T, Douglas J. Transanal endoscopic excision of rectal adenomas. Surg Endosc. 2003;17:1461–3.

    Article  CAS  PubMed  Google Scholar 

  149. Maslekar S, Pillinger SH, Sharma A, Taylor A, Monson JRT. Cost analysis of transanal endoscopic microsurgery for rectal tumours. Color Dis. 2007;9:229–34.

    Article  CAS  Google Scholar 

  150. Sylla P. Current experience and future directions of completely NOTES colorectal resection. World J Gastrointest Surg. 2010;2:193–8.

    Article  PubMed  PubMed Central  Google Scholar 

  151. Emhoff IA, Lee GC, Sylla P. Transanal colorectal resection using natural orifice translumenal endoscopic surgery (NOTES). Dig Endosc. 2014;26(Suppl 1):29–42.

    Article  PubMed  Google Scholar 

  152. Lee GC, Sylla P. Shifting paradigms in minimally invasive surgery: applications of transanal natural orifice transluminal endoscopic surgery in colorectal surgery. Clin Colon Rectal Surg. 2015;28:181–93.

    Article  PubMed  PubMed Central  Google Scholar 

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Carmichael, H., Sylla, P. (2018). Local Excision: Transanal Endoscopic Microsurgery and Transanal Minimally Invasive Surgery. In: Chang, G. (eds) Rectal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-16384-0_4

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