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Epigenetic Epidemiology

  • Book
  • © 2022
  • Latest edition

Overview

Editors:
  1. Karin B. Michels

    1. Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, USA

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  • Fundamentally revised and updated edition of this must-have reference book
  • Assists in interpreting and understanding epigenetic evidence in humans
  • Covers cutting-edge topics such as the epigenetic clock, single-cell analysis, and metastable epialleles

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Basic Concepts and Methodologic Considerations

    1. Front Matter

      Pages 1-1
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    2. The Human Epigenome

      • Rochelle L. Tiedemann, Gangning Liang, Peter A. Jones
      Pages 3-25

    3. Considerations in the Design, Conduct, and Interpretation of Studies in Epigenetic Epidemiology

      • Karin B. Michels
      Pages 27-44

    4. Laboratory Methods in Epigenetic Epidemiology

      • Ludovic Barault, Rebecca C. Rancourt
      Pages 45-66

    5. Cell-Type Heterogeneity in DNA Methylation Studies: Statistical Methods and Guidelines

      • Andrew E. Teschendorff
      Pages 67-96

    6. Epigenetics in Development

      • Victor Yuan, Wendy P. Robinson
      Pages 97-121

    7. The Role of Epigenetics in the Developmental Origins of Health and Disease

      • Karin B. Michels, Chatura J. Gunasekara, Robert A. Waterland
      Pages 123-142

    8. Epigenetics and Assisted Reproductive Technologies

      • Suneeta Senapati, Sneha Mani, Jayashri Ghosh, Christos Coutifaris, Carmen Sapienza, Monica Mainigi
      Pages 143-170

    9. Genomic Imprinting: A Paradigm for Epigenetics of Human Diseases

      • R. M. John, L. Lefebvre, M. A. Surani
      Pages 171-212

    10. The Utility of Twins for Epigenetic Analysis

      • Richard Saffery, Jordana T. Bell
      Pages 213-233

    11. Age-Related Variation in DNA Methylation

      • Kelsey Keith, Jean-Pierre J. Issa, Shoghag Panjarian
      Pages 235-259

    12. Epigenetic Clocks

      • Alexandra M. Binder, Steve Horvath
      Pages 261-276

    13. Influence of Environmental Factors on the Epigenome

      • Brock C. Christensen, Todd M. Everson, Carmen J. Marsit, Karl T. Kelsey
      Pages 277-322

  3. Epigenetic Epidemiology of Complex Diseases

    1. Front Matter

      Pages 323-323
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    2. Epigenetic Epidemiology of Cancer

      • Zdenko Herceg, Akram Ghantous, Felicia Fei-Lei Chung
      Pages 325-342

    3. Epigenetic Epidemiology of Infectious Diseases

      • Toshikazu Ushijima, Yumi Furuichi, Hideyuki Takeshima, Naoko Hattori
      Pages 343-361

    4. Epigenetic Epidemiology of Inflammation and Rheumatoid Arthritis

      • Caroline Ospelt, Steffen Gay
      Pages 363-380

    5. Asthma Epigenetics: Elucidating an Expanding Paradigm

      • Rachel L. Miller, James Chen
      Pages 381-404

    6. Epigenetic Epidemiology of Autism and Other Neurodevelopmental Disorders

      • Sung Eun Wang, Yong-Hui Jiang
      Pages 405-426
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Keywords

About this book

Now in its second edition, this book provides a state of the art overview on basic concepts of epigenetic epidemiology and a comprehensive review of the rapidly evolving field of human epigenetics.

Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. Unlike our genetic inheritance, our epigenome is malleable throughout the lifecourse and is shaped by our environmental experiences. Population-based epidemiologic studies increasingly incorporate epigenetic components. These so called epigenome-wide association studies (EWAS) contribute substantially to our understanding of the relevance of epigenetic marks, such as DNA methylation, histone modification, and non-coding RNAs for disease causation.

Written by leading experts in the field, the book opens with a comprehensive introduction of the principles of epigenetic epidemiology and discusses challenges in study design, analysis, and interpretation. It summarizesthe latest advances in epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the epigenetic clock, and the role of epigenetics in the developmental origins hypothesis. The final part focuses on epigenetic epidemiology of various health conditions such as imprinting disorders, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, metabolic disorder and vascular disease, as well as neurodevelopmental and psychiatric disorders.

Given its scope, Epigenetic Epidemiology is an indispensable resource for researchers working in the field of human epigenetics.

Editors and Affiliations

  • Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, USA

    Karin B. Michels

About the editor

Karin B. Michels is Professor and Chair of the Department of Epidemiology at the Fielding School of Public Health at UCLA. She received a ScD in Epidemiology from Harvard University and a PhD in Biostatistics from Cambridge University, UK. She was Assistant and Associate Professor at Harvard Medical School until she joined UCLA in 2016. Dr. Michels is a co-founder of the field of epigenetic epidemiology. Her work focusses on the early life origins of cancer, the role of nutrition in maintaining health, and the impact of the environment on the epigenome and the microbiome. She has published more than 300 peer-reviewed publications. Her work has been supported by the National Institutes of Health, the American Cancer Society, the Department of Defense, the Komen Foundation, and the Breast Cancer Research Foundation.

Bibliographic Information

  • Book Title: Epigenetic Epidemiology

  • Editors: Karin B. Michels

  • DOI: https://doi.org/10.1007/978-3-030-94475-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022

  • Hardcover ISBN: 978-3-030-94474-2Published: 15 April 2022

  • Softcover ISBN: 978-3-030-94477-3Published: 16 April 2023

  • eBook ISBN: 978-3-030-94475-9Published: 14 April 2022

  • Edition Number: 2

  • Number of Pages: XIV, 510

  • Number of Illustrations: 3 b/w illustrations, 39 illustrations in colour

  • Topics: Genetics and Genomics, Epidemiology, Biochemistry, general

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