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Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles

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Green Chemistry in Drug Discovery

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

The application of multicomponent reactions (MCRs) in the generation of compound libraries has long been recognized as a key strategy for the development of lead matter in drug discovery. Given the numerous advantages that these processes possess not only from the ability to generate large numbers of diverse compounds but also from a sustainability perspective, it is somewhat surprising that MCRs have not enjoyed such a widespread application in downstream development and the later scale-up of pharmaceutical candidates. The current chapter provides an overview of the most common MCRs with a critical focus on their perceived benefits as a sustainable technology. In addition, an overview of the combination of MCRs with other “green” technologies such as both biocatalysis and flow chemistry is also provided.

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Authors and Affiliations

  1. Department of Chemistry & Pharmaceutical Sciences, Amsterdam Institute of Molecules, Medicines & Systems, VU University Amsterdam, Amsterdam, The Netherlands

    Razvan Cioc, Eelco Ruijter & Romano V. A. Orru

  2. Aachen-Maastricht Institute for Biobased Materials (AMIBM), Maastricht University , Brightlands Chemelot Campus, Center Court, Urmonderbaan, Geleen, Netherlands

    Romano V. A. Orru

Authors
  1. Razvan Cioc
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  2. Eelco Ruijter
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  3. Romano V. A. Orru
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Correspondence to Romano V. A. Orru .

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  1. World Wide Medicinal Chemistry, Pfizer Inc., San Diego, CA, USA

    Paul F. Richardson

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Cioc, R., Ruijter, E., Orru, R.V.A. (2022). Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles. In: Richardson, P.F. (eds) Green Chemistry in Drug Discovery. Methods in Pharmacology and Toxicology. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1579-9_8

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  • DOI: https://doi.org/10.1007/978-1-0716-1579-9_8

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