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Trypsin-Catalyzed One-Pot Multicomponent Synthesis of 4-Thiazolidinones

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Abstract

A facile enzymatic one-pot multicomponent synthesis of 4-thiazolidinones was developed. The trypsin from porcine pancreas displayed great catalytic activity to promote the reaction of aldehyde, amine and mercaptoacetic acid with high yields showing a broad substrate specificity in this reaction. This trypsin-catalyzed multicomponent conversion method provided a novel strategy to synthesize thiazolidinones and expanded the application of trypsin in organic synthesis.

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Acknowledgments

We are grateful to the National Natural Science Foundation of China (No. 21106026) and Key Sci-tech Innovation Team of Zhejiang Province (No. 2010R50017-7) and HNUEYT (2011-01-13) for providing financial support.

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Authors and Affiliations

  1. College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036, People’s Republic of China

    Hui Zheng, Yi-Jia Mei, Kui Du, Qiao-Yue Shi & Peng-Fei Zhang

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  1. Hui Zheng
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  2. Yi-Jia Mei
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  3. Kui Du
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  4. Qiao-Yue Shi
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  5. Peng-Fei Zhang
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Correspondence to Hui Zheng.

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Zheng, H., Mei, YJ., Du, K. et al. Trypsin-Catalyzed One-Pot Multicomponent Synthesis of 4-Thiazolidinones. Catal Lett 143, 298–301 (2013). https://doi.org/10.1007/s10562-013-0962-1

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  • DOI: https://doi.org/10.1007/s10562-013-0962-1

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