Multicomponent reactions are emerging as a powerful tool in alkaloid-based drug discovery. This highlight describes several recent (all published in 2011) examples of the employment of multicomponent reactions for the synthesis of biologically active alkaloids and their medicinally relevant analogs.
Similar content being viewed by others
References
J. Zhu and H. Bienyamé (editors), Multicomponent Reactions, Wiley-VCH, Weinheim (2005).
A. Doemling, Chem. Rev., 106, 17 (2006).
R. Robinson, J. Chem. Soc., 762 (1917).
B. B. Touré and D. G. Hall, Chem. Rev., 109, 4439 (2009).
O. Pando, S. Stark, A. Denkert, A. Porzel, R. Preusentanz, and L. A. Wessjohann, J. Am. Chem. Soc., 133, 7692 (2011).
M.-C. Tseng, Y.-W. Chu, H.-P. Tsai, C.-M. Lin, J. Hwang, and Y.-H. Chu, Org. Lett., 13, 920 (2011).
L. V. Frolova, N. M. Evdokimov, K. Hayden, I. Malik, S. Rogelj, A. Kornienko, and I. V. Magedov, Org. Lett., 13, 1118 (2011).
P. Garner, H. U. Kaniskan, C. M. Keyari, and L. Weerasinghe, J. Org. Chem., 76, 5283 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 38-43, January, 2012.
Rights and permissions
About this article
Cite this article
Magedov, I.V., Kornienko, A. Multicomponent reactions in alkaloid-based drug discovery. Chem Heterocycl Comp 48, 33–38 (2012). https://doi.org/10.1007/s10593-012-0965-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10593-012-0965-7