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The Role of MiRNA in Cancer: Pathogenesis, Diagnosis, and Treatment

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miRNomics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2257))

Abstract

Cancer is also determined by the alterations of oncogenes and tumor suppressor genes. These gene expressions can be regulated by microRNAs (miRNA). At this point, researchers focus on addressing two main questions: “How are oncogenes and/or tumor suppressor genes regulated by miRNAs?” and “Which other mechanisms in cancer cells are regulated by miRNAs?” In this work we focus on gathering the publications answering these questions. The expression of miRNAs is affected by amplification, deletion or mutation. These processes are controlled by oncogenes and tumor suppressor genes, which regulate different mechanisms of cancer initiation and progression including cell proliferation, cell growth, apoptosis, DNA repair, invasion, angiogenesis, metastasis, drug resistance, metabolic regulation, and immune response regulation in cancer cells. In addition, profiling of miRNA is an important step in developing a new therapeutic approach for cancer.

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Authors and Affiliations

  1. Molecular Biology and Genetics, Izmir Institute of Technology, Izmir, Turkey

    Erez Uzuner, Gizem Tugçe Ulu, Sevim Beyza Gürler & Yusuf Baran

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  1. Erez Uzuner
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  2. Gizem Tugçe Ulu
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  3. Sevim Beyza Gürler
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  4. Yusuf Baran
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  1. Medical Informatics and Bioinformatics, Institute for Measurement Engineering and Sensor Technology, Hochschule Ruhr West, University of Applied Sciences, Mülheim adR, Germany

    Jens Allmer

  2. Department of Information System, Galilee Digital Health Research Center (GDH), Zefat Academic College, Zefat, Israel

    Malik Yousef

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Uzuner, E., Ulu, G.T., Gürler, S.B., Baran, Y. (2022). The Role of MiRNA in Cancer: Pathogenesis, Diagnosis, and Treatment. In: Allmer, J., Yousef, M. (eds) miRNomics. Methods in Molecular Biology, vol 2257. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1170-8_18

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